Factors affecting sex hormone levels in postmenopausal women.
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In ZR-75-1 cells, concentrations of DHT in the incubation medium similar to the plasma levels found in normal women and breast cancer patients (0.3-0.7 nM) are potent inhibitors of the mitogenic effect of E2 and even inhibit growth in the absence of estrogens.
“In ZR-75-1 cells, concentrations of DHT in the incubation medium similar to the plasma levels found in normal women (215-217) and breast cancer patients (Ref.218; 0.3-0.7 nm) are potent inhibitors of the mitogenic effect of E 2 and even inhibit growth in the absence of estrogens (208).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [217]
4-Dione also led to significant growth inhibition in ZR-75-1 cells, although the active concentrations (IC50, 15 nM) are in the upper range of the plasma concentrations (1-10 nM) found in women.
“4-Dione also led to significant growth inhibition in ZR-75-1 cells, although the active concentrations (IC 50 , 15 nm) are in the upper range of the plasma concentrations (1-10 nm) found in women (215-218).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [217]
Cites
Source of Estrogen Production in Postmenopausal Women1
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HEMSELL, D. L., GRODIN, J. M., BRENNER, P. F., SIITERI, P. K., & MACDONALD, P. C. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-3-476 · Cited by 444 · see citing works
MacDonald, P. C., Edman, C. D., Hemsell, D. L., Porter, J. C., & Siiteri, P. K. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90287-9 · Cited by 440 · see citing works
The hormonal activity of the postmenopausal ovary.
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Self-citationVermeulen, A., & Verdonck, L. (1978) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1978.tb03572.x · Cited by 156 · see citing works
Self-citationSerum 17β-Estradiol and Estrone Levels in Postmenopausal Women With and Without Endometrial Cancer
Judd, H. L., Lucas, W. E., & Yen, S. S. C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-2-272 · Cited by 152 · see citing works
Vermeulen, A., & Verdonck, L. (1976) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(76)90156-4 · Cited by 134 · see citing works
Self-citationVermeulen, A., & Andò, S. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-2-320 · Cited by 95 · see citing works
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In VivoStudies on the Metabolism of Estrogens by Muscle and Adipose Tissue of Normal Males
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Plasma estrogens in postmenopausal women
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Δ5-Androstenediol: Kinetics of Metabolism and Binding to Plasma Proteins in Normal Men and Women1
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Studies About Unconjugated Androstenediol in Human Peripheral Plasma1
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Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Fat Tissue: A Steroid Reservoir and Site of Steroid Metabolism
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Self-citationPoulin, R., Baker, D., & Labrie, F. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01805942 · Cited by 172 · see citing works
Estrogen metabolism in abdominal subcutaneous and visceral adipose tissue in postmenopausal women
Hetemäki, N., Savolainen-Peltonen, H., Tikkanen, M. J., Wang, F., Paatela, H., Hämäläinen, E., Turpeinen, U., Haanpää, M., Vihma, V., & Mikkola, T. S. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01474 · Cited by 140 · see citing works
Cigarette smoking, steroid hormones, and bone mineral density in young women
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- Authors
- Vermeulen, A., & Verdonck, L.
- Affiliations
- Ghent University (BE)
- ORCID
- Vermeulen, A.
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1979-07
- Volume
- 11
- Issue
- 1
- Pages
- 899-904
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W2038967167
- Cited by
- 61
- References
- 16
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2017: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- postmenopausal women, sex hormone levels, estrogen, androgens, ovarian steroid secretion, aromatization, fat mass, estradiol, estrone, testosterone, menopause duration
- MeSH terms
- Addison Disease, Adipose Tissue, Aged, Androgens, Androstenedione, Estradiol, Estrogens, Estrone, Female, Humans, Hysterectomy, Menopause, Middle Aged, Dihydrotestosterone, Testosterone
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