The DOI matches its Crossref record.
Low Serum Triiodothyronine in Patients with Anorexia Nervosa
Abstract
Patients with anorexia nervosa can demonstrate clinical and/or laboratory findings suggestive of reduced thyroid hormone secretion. In this study, the thyroxine (T4) and triiodothyronine (T3) serum concentrations, and thyrotropin (TSH) response to intravenous administration of thyrotropin releasing hormone (TRH) were determined in 6 patients (aged 9 to 15 yr) with anorexia nervosa and the results compared to those found in a group of 15 normal subjects. The mean basal TSH concentration and mean maximum increase in TSH after TRH were comparable to those in the normal subjects. The mean T4 concentration (7.2 mug/100 ml) in the anorexia nerovsa group was slightly but significantly lower than in the normal group (9.5 mug/100 ml). Five of the 6 patients had serum T3 concentrations below the lower limits of normal and the mean T3 concentrations (49.7 ng/100 ml) was significantly lower than in the normal group (106 ng/100 ml). The extremely low serum levels of T3 in these patients with anorexia nervosa suggest that peripheral conversion of T4 to T3 is impaired during chronic starvation.
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Citations
Cited by
Becker, A. E., Grinspoon, S. K., Klibanski, A., & Herzog, D. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904083401407 · Cited by 414
Non-Thyroidal Illness in the ICU: A Syndrome with Different Faces
Van den Berghe, G. (2014) · Thyroid® · doi:10.1089/thy.2014.0201 · Cited by 316
Hypothalamic Dysfunction in Secondary Amenorrhea Associated with Simple Weight Loss
Vigersky, R. A., Andersen, A. E., Thompson, R. H., & Loriaux, D. L. (1977) · New England Journal of Medicine · doi:10.1056/nejm197711242972103 · Cited by 311
Cortisol Secretion and Metabolism in Anorexia Nervosa
Boyar, R. M., Hellman, L. D., Roffwarg, H., Katz, J., Zumoff, B., O'Connor, J., Bradlow, H. L., & Fukushima, D. K. (1977) · New England Journal of Medicine · doi:10.1056/nejm197701272960403 · Cited by 285
EFFECT OF CALORIC RESTRICTION AND DIETARY COMPOSITION ON SERUM T3AND REVERSE T3IN MAN
Spaulding, S. W., Chopra, I. J., Sherwin, R. S., & Lyall, S. S. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-1-197 · Cited by 278
Metadata
- Authors
- MOSHANG, T., PARKS, J. S., BAKER, L., VAIDYA, V., UTIGER, R. D., BONGIOVANNI, A. M., & SNYDER, P. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1975-03
- Volume
- 40
- Issue
- 3
- Pages
- 470-473
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1989753865
- Cited by
- 160
- References
- 0
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- MOSHANG, T., PARKS, J. S., BAKER, L., VAIDYA, V., UTIGER, R. D., BONGIOVANNI, A. M., & SNYDER, P. J. (1975). Low Serum Triiodothyronine in Patients with Anorexia Nervosa. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-40-3-470
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
