The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
EFFECT OF CALORIC RESTRICTION AND DIETARY COMPOSITION ON SERUM T3AND REVERSE T3IN MAN
Abstract
To evaluate the effect of caloric restriction and dietary composition on circulating T3 and rT3 obese subjects were studied after 7-18 days of total fasting and while on randomized hypocaloric diets (800 kcal) in which carbohydrate content was varied to provide from 0 to 100% calories. As anticipated, total fasting resulted in a 53% reduction in serum T3 in association with reciprocal 58% increase in rT3. Subjects receiving the no-carbohydrate hypocaloric diets for two weeks demonstrated a similar 47% decline in serum T3 but there was no significant change in rT3 with time. In contrast, the same subjects receiving isocaloric diets containing at least 50 g of carbohydrate showed no significant changes in either T3 or rT3 concentration. The decline in serum T3 during the no-carbohydrate diet correlated significantly with blood glucose and ketones but there was no correlation with insulin or glucagon. We conclude that dietary carbohydrate is an important regulatory factor in T3 production in man. In contrast, rT3 concentration is not significantly affected by changes in dietary carbohydrate. Our data suggest that the rise in serum rT3 during starvation may be related to more severe caloric restriction than that caused by the 800 kcal diet.
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Citations
Cites
A Radioimmunoassay for Measurement of Thyroxine in Unextracted Serum*
CHOPRA, I. J. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-6-938 · Cited by 539
Self-citationCHOPRA, I. J., CHOPRA, U., SMITH, S. R., REZA, M., & SOLOMON, D. H. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-6-1043 · Cited by 424
Self-citationVagenakis, A. G., Burger, A., Portnay, G. I., Rudolph, M., O'Brain, J. T., Azizi, F., Arky, R. A., Nicod, P., Ingbar, S. H., & Braverman, L. E. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-1-191 · Cited by 373
Effect of ketone infusions on amino acid and nitrogen metabolism in man.
Sherwin, R. S., Hendler, R. G., & Felig, P. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108057 · Cited by 335
Self-citationCHOPRA, I. J., HO, R. S., & LAM, R. W. (1972) · PubMed · Cited by 286
Self-citationInfluence of Glucocorticoids on Glucagon Secretion and Plasma Amino Acid Concentrations in Man
Wise, J. K., Hendler, R., & Felig, P. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107473 · Cited by 256
Portnay, G. I., O'Brian, J. T., Bush, J., Vagenakis, A. G., Azizi, F., Arky, R. A., Ingbar, S. H., & Braverman, L. E. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-1-191 · Cited by 252
A Radioimmunoassay for Measurement of 3,3′, 5′-Triiodothyronine (Reverse T3)
Chopra, I. J. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107795 · Cited by 251
Self-citationCirculating Thyroid Hormones and Thyrotropin in Adult Patients with Protein-Calorie Malnutrition
CHOPRA, I. J., & SMITH, S. R. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-2-221 · Cited by 171
Self-citationLow Serum Triiodothyronine in Patients with Anorexia Nervosa
MOSHANG, T., PARKS, J. S., BAKER, L., VAIDYA, V., UTIGER, R. D., BONGIOVANNI, A. M., & SNYDER, P. J. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-3-470 · Cited by 160
Cited by
The Effects of Exercise on Pubertal Progression and Reproductive Function in Girls*
WARREN, M. P. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-5-1150 · Cited by 613
Efficacy and Safety of Low-Carbohydrate Diets: A Systematic Review
Bravata, D. M., Sanders, L., Huang, J., Krumholz, H. M., Olkin, I., Gardner, C. D., & Bravata, D. M. (2003) · JAMA · doi:10.1001/jama.289.14.1837 · Cited by 561
Dietary-induced alterations in thyroid hormone metabolism during overnutrition.
Danforth, E., Horton, E. S., O'Connell, M., Sims, E. A., Burger, A. G., Ingbar, S. H., Braverman, L., & Vagenakis, A. G. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109590 · Cited by 310
Paradigms of dynamic control of thyroid hormone signaling
Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M. L. C. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00275 · Cited by 293
Santini, F., Marzullo, P., Rotondi, M., Ceccarini, G., Pagano, L., Ippolito, S., Chiovato, L., & Biondi, B. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0067 · Cited by 240
Metadata
- Authors
- Spaulding, S. W., Chopra, I. J., Sherwin, R. S., & Lyall, S. S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1976-01
- Volume
- 42
- Issue
- 1
- Pages
- 197-200
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1968861570
- Cited by
- 278
- References
- 11
- FWCI
- 22.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: EFFECT OF CALORIC RESTRICTION AND DIETARY COMPOSITION ON SERUM T3AND REVERSE T3IN MAN. https://app.cochat.ai/papers/10.1210/jcem-42-1-197
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- Spaulding, S. W., Chopra, I. J., Sherwin, R. S., & Lyall, S. S. (1976). EFFECT OF CALORIC RESTRICTION AND DIETARY COMPOSITION ON SERUM T3AND REVERSE T3IN MAN. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-42-1-197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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