A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis

CONTE, FELIX A.; GRUMBACH, MELVIN M.; KAPLAN, SELNA L.

doi:10.1210/jcem-40-4-670

Cited by 276Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis

CONTE, FELIX A., GRUMBACH, MELVIN M., KAPLAN, SELNA L.·1975·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-40-4-670

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Abstract

Cross sectional and longitudinal studies of plasma FSH and LH in 58 patients, age 2 days of 20 yr, with the syndrome of gonadal dysgenesis show a diphasic pattern of gonadotropin secretion. The mean basal plasma FSH level is 43 plus or minus 7 (SE) ng/ml (LER-869) in patients from 2 days to 4 yr, which is strikingly elevated. Thereafter, a decline in plasma FSH to a mean level of 4 plus or minus 0.7 (SE) ng/ml occurs between 4 and 10 yr, followed by a rise after 10 yr to 61 plus or minus 4 (SE) ng/ml. The pattern of LH (LER-960) secretion is qualitatively similar to that of FSH, although quantitatively the values for LH are 1/3 to 1/10 those for FSH. The similarity of pattern of gonadotropin secretion observed between patients with gonadal dysgenesis and normal children suggests that gonadal function does not play a decisive role in the pattern of gonadotropin secretion from infancy through adolescence, but exercises striking effects on the quantity of gonadotropin secreted.

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Circulating concentrations of both FSH and LH present a biphasic pattern in Turner syndrome individuals with hypogonadism: elevated after birth, declining to values similar to girls with normal ovarian function during mid-childhood, and rising again in the peripubertal years or at the time of loss of ovarian function.
“Circulating concentrations of both FSH and LH present a biphasic pattern in TS individuals with hypogonadism: elevated after birth, declining to values similar to girls with normal ovarian function during mid-childhood, and rising again in the peripubertal years, or at the time of loss of ovarian function.”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [268]

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Authors: CONTE, F. A., GRUMBACH, M. M., & KAPLAN, S. L.
Affiliations: University of California, San Francisco (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1975-04
Volume: 40
Issue: 4
Pages: 670-674
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-40-4-670
OpenAlex: W2104675247
Cited by: 276
References: 0
Citations by year: 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 6
FWCI: 5.71
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Keywords: gonadal dysgenesis, follicle-stimulating hormone, luteinizing hormone, plasma gonadotropin levels, adolescence, gonadal function, Kallmann syndrome
MeSH terms: Adolescent, Adult, Age Factors, Child, Child, Preschool, Estradiol, Estrone, Female, Follicle Stimulating Hormone, Humans, Infant, Infant, Newborn, Luteinizing Hormone, Radioimmunoassay, Turner Syndrome

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A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis

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