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Cited by 379Ovarian function and disordersEstrogen and related hormone effectsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

The hormonal activity of the postmenopausal ovary.

VERMEULEN, A.·1976·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-42-2-247
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Abstract

The origin of plasma sex hormones in postmenopausal women was studied by determining plasma levels under basal conditions, after ACTH stimulation, and after dexamethasone suppression, as well as after hCG stimulation. Values obtained in postmenopausal women were compared with values observed during the follicular phase of the cycle in young women on the one hand, and with values in ovariectomized women of postmenopausal age on the other hand. All sex steroid levels studied with the exception of estrone, were significantly lower in postmenopausal women than in young women during the early follicular phase of the cycle. In ovariectomized women only androgen levels (testosterone, androstenedione, dihydrotestosterone, and to a lesser extent dehydroepiandrosterone,) were lower than in normal postmenopausal women, estrogen, 17 hydroxyprogesterone, and progesterone levels being similar. ACTH increased all plasma steroid levels except estradiol, whereas after dexamethasone, all sex hormone levels were significantly decreased. hCG stimulation finally caused an increase of borderline statistical significance in testosterone, dehydroepiandrosterone, and 17-hydroxyprogesterone levels. We have concluded from this study that the adrenal cortex is almost the exclusive source of plasma estradiol, estrone, progesterone, and 17OH progesterone and the most important source of plasma dehydroepiandrosterone; that the postmenopausal ovary appears to be responsible for about 50% of plasma testosterone and 30% of androstenedione levels; and that hCG stimulation with 5000 IU daily for 3 days, hardly influences steroid secretion by postmenopausal ovaries.

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Metadata

Authors
VERMEULEN, A.
Affiliations
Ghent University (BE)
Corresponding author
VERMEULEN, A.
ORCID
VERMEULEN, A.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1976-02
Volume
42
Issue
2
Pages
247-253
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-42-2-247
OpenAlex
W1992502576
Cited by
379
References
20
Citations by year
2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 5
FWCI
13.61
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
postmenopausal ovary, ovarian steroid secretion, plasma sex hormones, estradiol, estrone, progesterone, 17-hydroxyprogesterone, testosterone, androstenedione, dehydroepiandrosterone, adrenal cortex, ACTH stimulation test, dexamethasone suppression, hCG stimulation, ovariectomy
MeSH terms
Adrenal Glands, Adrenocorticotropic Hormone, Aged, Androstenedione, Castration, Circadian Rhythm, Dehydroepiandrosterone, Dexamethasone, Estradiol, Estrone, Female, Chorionic Gonadotropin, Humans, Hydroxyprogesterones, Menopause, Middle Aged, Ovary, Progesterone, Gonadal Steroid Hormones, Dihydrotestosterone, Testosterone

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