Cited by 379Ovarian function and disordersEstrogen and related hormone effectsAdrenal Hormones and Disorders

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The hormonal activity of the postmenopausal ovary.

VERMEULEN, A.·1976·The Journal of Clinical Endocrinology & Metabolism

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Abstract

The origin of plasma sex hormones in postmenopausal women was studied by determining plasma levels under basal conditions, after ACTH stimulation, and after dexamethasone suppression, as well as after hCG stimulation. Values obtained in postmenopausal women were compared with values observed during the follicular phase of the cycle in young women on the one hand, and with values in ovariectomized women of postmenopausal age on the other hand. All sex steroid levels studied with the exception of estrone, were significantly lower in postmenopausal women than in young women during the early follicular phase of the cycle. In ovariectomized women only androgen levels (testosterone, androstenedione, dihydrotestosterone, and to a lesser extent dehydroepiandrosterone,) were lower than in normal postmenopausal women, estrogen, 17 hydroxyprogesterone, and progesterone levels being similar. ACTH increased all plasma steroid levels except estradiol, whereas after dexamethasone, all sex hormone levels were significantly decreased. hCG stimulation finally caused an increase of borderline statistical significance in testosterone, dehydroepiandrosterone, and 17-hydroxyprogesterone levels. We have concluded from this study that the adrenal cortex is almost the exclusive source of plasma estradiol, estrone, progesterone, and 17OH progesterone and the most important source of plasma dehydroepiandrosterone; that the postmenopausal ovary appears to be responsible for about 50% of plasma testosterone and 30% of androstenedione levels; and that hCG stimulation with 5000 IU daily for 3 days, hardly influences steroid secretion by postmenopausal ovaries.

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Source of Estrogen Production in Postmenopausal Women1
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Authors: VERMEULEN, A.
Affiliations: Ghent University (BE)
Corresponding author: VERMEULEN, A.
ORCID: VERMEULEN, A.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1976-02
Volume: 42
Issue: 2
Pages: 247-253
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-42-2-247
OpenAlex: W1992502576
Cited by: 379
References: 20
Citations by year: 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 5
FWCI: 13.61
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: postmenopausal ovary, ovarian steroid secretion, plasma sex hormones, estradiol, estrone, progesterone, 17-hydroxyprogesterone, testosterone, androstenedione, dehydroepiandrosterone, adrenal cortex, ACTH stimulation test, dexamethasone suppression, hCG stimulation, ovariectomy
MeSH terms: Adrenal Glands, Adrenocorticotropic Hormone, Aged, Androstenedione, Castration, Circadian Rhythm, Dehydroepiandrosterone, Dexamethasone, Estradiol, Estrone, Female, Chorionic Gonadotropin, Humans, Hydroxyprogesterones, Menopause, Middle Aged, Ovary, Progesterone, Gonadal Steroid Hormones, Dihydrotestosterone, Testosterone

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The hormonal activity of the postmenopausal ovary.

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