The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Adrenocortical Function in Hyperprolactinemic Women
Abstract
To study the effects of prolactin (PRL) on adrenocortical function in humans, dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (delta) and testosterone (T) were measured in serum obtained from 35 hyperprolactinemic women with galactorrhea and amenorrhea before and after treatment with bromocriptine-induced fall in mean PRL levels from 82 +/- 8 (SE) to 14 +/- 2 ng/ml (n = 39, P less than 0.0005), DHAS fell from 322 +/- 21 to 237 +/- 21 microgram/dl (n = 39); P less than 0.0005), DHA fell from 492 +/- 47 to 378 +/- 30 ng/dl (n = 39; P less than 0.01) while T (n = 16) and delta (n = 13) levels were unchanges (44 +/- 4 vs. 49 +/- 4 ng/dl and 280 +/- 55 vs. 236 +/- 40 ng/dl, respectively). In addition, 4 women were infused iv with 25 microgram synthetic ACTH over 4 h and serial blood samples drawn while hyperprolactinemic, and again 2-4 months later following normalization of PRL levels by bromocriptine. Although pre-infusion levels of DHAS were lower when PRL levels were normalized, no significant differences in responses of circulating DHAS, DHA, T, cortisol and 17-hydroxyprogesterone concentrations were detected between the two infusions. Since DHAS is virtually an exclusive product of the adrenal cortex, and since high PRL levels appear to inhibit ovarian steroid production, the findings suggest that hyperprolactinemia selectively stimulates adrenocortical androgen production.
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“These data are also consistent with the in vivo studies cited before showing that PRL has a selective stimulatory effect on adrenal androgen production 12,23-29 .”
From ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures (2023) · cites this paper as [26]
In the citing paper
“A number of studies have described the association of hyperprolactinemia with increased adrenal androgen levels and an increased adrenocortical response to ACTH in patients with high circulating PRL levels 12,23-29 .”
From ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures (2023) · cites this paper as [26]
Citations
Cites
A Radioimmunoassay for Human Prolactin
Hwang, P., Guyda, H., & Friesen, H. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.8.1902 · Cited by 752
Posner, B. I., Kelly, P. A., Shiu, R. P. C., & Friesen, H. G. (1974) · Endocrinology · doi:10.1210/endo-95-2-521 · Cited by 584
A possible role for prolactin in control of steroid secretion by the human Graafian follicle
McNatty, K. P., SAWERS, R. S., & McNeilly, A. S. (1974) · Nature · doi:10.1038/250653a0 · Cited by 462
Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle
ABRAHAM, G. E. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-2-340 · Cited by 436
Long-term Treatment of Galactorrhoea and Hypogonadism with Bromocriptine
Thorner, M. O., McNeilly, A. S., Hagan, C., & BESSER, G. M. (1974) · BMJ · doi:10.1136/bmj.2.5916.419 · Cited by 406
Winter, J. S. D., Hughes, I. A., Reyes, F. I., & Faiman, C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-4-679 · Cited by 367
Hyperprolactinemic Anovulatory Syndrome*
Bohnet, H. G., Dahlén, H. G., Wuttke, W., & Schneider, H. P. G. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-1-132 · Cited by 264
Radioimmunoassay of Plasma Dehydroepiandrosterone Sulfate
Buster, J. E., & Abraham, G. E. (1972) · Analytical Letters · doi:10.1080/00032717208062119 · Cited by 239
Forbes, A. P., Henneman, P. H., Griswold, G. C., & Albright, F. (1954) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-14-3-265 · Cited by 229
Chromatographic Separation of Steroid Hormones for Use in Radioimmunoassay
Abraham, G. E., Buster, J. E., Lucas, L. A., Corrales, P. C., & Teller, R. C. (1972) · Analytical Letters · doi:10.1080/00032717208062116 · Cited by 214
Cited by
Sorted by citations
Hirsutism: Implications, etiology, and management
Hatch, R., Rosenfield, R. L., Kim, M. H., & Tredway, D. R. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90746-8 · Cited by 1,013
REVIEW ARTICLE: THE POLYCYSTIC OVARY SYNDROME
Yen, S. S. C. (1980) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1980.tb02132.x · Cited by 697
1 Adrenal and gonadal androgen secretion in normal females
Longcope, C. (1986) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(86)80021-4 · Cited by 332
Prolactin — a pleiotropic factor in health and disease
Bernard, V., Young, J., & Binart, N. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0194-6 · Cited by 283
Control of adrenal androgen secretion.
Parker, L. N., & Odell, W. (1980) · Endocrine reviews · doi:10.1210/edrv-1-4-392 · Cited by 184
Metadata
- Authors
- CARTER, J. N., TYSON, J. E., WARNE, G. L., McNEILLY, A. S., FAIMAN, C., & FRIESEN, H. G.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- McNEILLY, A. S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1977-11
- Volume
- 45
- Issue
- 5
- Pages
- 973-980
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2017313133
- Cited by
- 127
- References
- 26
- Citations by year
- 2023: 1 · 2022: 1 · 2019: 3 · 2013: 2 · 2012: 2
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- hyperprolactinemia, prolactin, adrenocortical function, dehydroepiandrosterone sulfate, dehydroepiandrosterone, androstenedione, testosterone, galactorrhea, amenorrhea, bromocriptine, ACTH stimulation test, adrenal androgen production, cortisol, 17-hydroxyprogesterone
- MeSH terms
- Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Amenorrhea, Androstenedione, Bromocriptine, Dehydroepiandrosterone, Female, Galactorrhea, Humans, Hydrocortisone, Pregnancy, Prolactin, Testosterone
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