Prolactin modulation of dehydroepiandrosterone sulfate secretion
Abstract
To clarify the controversy about the effect of prolactin (PRL) on dehydroepiandrosterone sulfate (DHEA-S), this study was undertaken to investigate the effects of alterations in plasma PRL on plasma DHEA-S concentrations in hyperprolactinemic women, as well as in normal male subjects. DHEA-S was measured in a group of 21 women with hyperprolactinemia, galactorrhea, and amenorrhea (PRL:257 +/- 89 ng/ml; mean +/- SEM). In these women, mean plasma concentrations of DHEA-S (2.54 +/- 0.2 microgram/ml) were significantly higher (p < 0.005) than those in 41 normal control women (1.78 z microgram/ml) and those in a group of 11 amenorrheic patients (1.77 +/- 0.2 microgram/ml). Eight women with hyperprolactinemia were given 5 mg of bromocriptine each day for 4 consecutive weeks. Within 1 week of medication, PRL levels fell by 60% (p < 0.05). To test whether lowering normal plasma levels of PRL would affect plasma concentrations of DHEA-S, five normal male subjects received a 48-hour infusion of dopamine at an average rate of 6 microgram/kg/min. Plasma levels of PRL fell by 60% (p < 0.01) after 8 hours of infusion, and DHEA-S decreased by 27% by 16 hours (p < 0.05). These data suggest that PRL modulates the secretion of DHEA-S: an increase in plasma levels of PRL is correlated with elevated concentrations of DHEA-S, whereas a decrease in PRL is followed by a fall in DHEA-S.
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In vivo studies show that PRL has a selective stimulatory effect on adrenal androgen production.
“These data are also consistent with the in vivo studies cited before showing that PRL has a selective stimulatory effect on adrenal androgen production 12,23-29 .”
From ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures (2023) · cites this paper as [29]
A number of studies have described an association of hyperprolactinemia with increased adrenal androgen levels and an increased adrenocortical response to ACTH in patients with high circulating PRL levels.
“A number of studies have described the association of hyperprolactinemia with increased adrenal androgen levels and an increased adrenocortical response to ACTH in patients with high circulating PRL levels 12,23-29 .”
From ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures (2023) · cites this paper as [29]
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Carmina, E., Bucchieri, S., Esposito, A., Del Puente, A., Mansueto, P., Orio, F., Di Fede, G., & Rini, G. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2725 · Cited by 317 · see citing works
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Lalli, E., & Figueiredo, B. C. (2022) · BioEssays · doi:10.1002/bies.202200109 · Cited by 10 · see citing works
Schneider, G., Ruggiero, C., Renault, L., Doghman-Bouguerra, M., Durand, N., Hingrai, G., Dijoud, F., Plotton, I., & Lalli, E. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad118 · Cited by 3 · see citing works
- Authors
- Lobo, R. A., Kletzky, O. A., Kaptein, E. M., & Goebelsmann, U.
- Affiliations
- University of Southern California (US)
- ORCID
- Kaptein, Elaine M.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1980-11
- Volume
- 138
- Issue
- 6
- Pages
- 632-636
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2144815733
- Cited by
- 120
- References
- 19
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- prolactin, dehydroepiandrosterone sulfate, hyperprolactinemia, galactorrhea, amenorrhea, bromocriptine, dopamine infusion, steroid secretion
- MeSH terms
- Adult, Amenorrhea, Androgens, Bromocriptine, Dehydroepiandrosterone, Dopamine, Female, Galactorrhea, Humans, Hydrocortisone, Lactation Disorders, Male, Pregnancy, Prolactin, Dehydroepiandrosterone Sulfate
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