The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
“MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS.
Abstract
Five women with endometriosis were given a daily dose of a potent long-acting GnRH agonist, D-Trp6-Pro9-Net-LHRH (GnRH-A) for 28 days in an attempt to suppress ovarian estrogen secretion. The mean level of estradiol (E2) during sampling over 24 hours decreased (P less than 0.01) from 62 +/- 11 to 10 +/- 1 pg/ml at the end of treatment. Mean concentrations of androstenedione, testosterone, estrone and E2 on day 28 of therapy were similar to those measured in oophorectomized women. The level of FSH was decreased (P less than 0.001) during GnRH-a, whereas that of LH was significantly (P less than 0.001) increased, suggesting differing intracellular control mechanisms for release of the two gonadotropins. Desensitization of the pituitary was demonstrated at the end of treatment by a complete lack of acute response of FSH or LH to the daily dose of GnRH-a. "Medical oophorectomy" provides a new approach to the treatment of endometriosis.
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Citations
Cites
Biochemical characterization of peritoneal fluid in women during the menstrual cycle
KONINCKX, P. R., VERHOEVEN, G., VAN BAELEN, H., LISSENS, W. D., DE MOOR, P., & BROSENS, I. A. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-6-1239 · Cited by 101
Cited by
Gonadotropin-releasing hormone and its analogues
Desforges, J. F., Conn, P. M., & Crowley, W. F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101103240205 · Cited by 470
Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis
Henzl, M. R., Corson, S. L., Moghissi, K., Buttram, V. C., Berqvist, C., & Jacobson, J. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802253180805 · Cited by 361
Dlugi, A. M., Miller, J. D., & Knittle, J. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53755-8 · Cited by 279
Chang, R. J., Laufer, L. R., Meldrum, D. R., Defazio, J., Lu, J. K. H., Vale, W. W., Rivier, J. E., & Judd, H. L. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-5-897 · Cited by 259
Self-citationGonadotropin-releasing hormone analogues for the treatment of endometriosis: long-term follow-up
Waller, K. G., & Shaw, R. W. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55791-4 · Cited by 252
Metadata
- Authors
- MELDRUM, D. R., CHANG, R. J., LU, J., VALE, W., RIVIER, J., & JUDD, H. L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1982-05
- Volume
- 54
- Issue
- 5
- Pages
- 1081-1083
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2086926841
- Cited by
- 248
- References
- 1
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: “MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS. https://app.cochat.ai/papers/10.1210/jcem-54-5-1081
- The paper
- MELDRUM, D. R., CHANG, R. J., LU, J., VALE, W., RIVIER, J., & JUDD, H. L. (1982). “MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-54-5-1081
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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