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Cited by 101Ovarian function and disordersReproductive Biology and FertilityEstrogen and related hormone effects

Biochemical characterization of peritoneal fluid in women during the menstrual cycle

KONINCKX, P.R., VERHOEVEN, G., VAN BAELEN, H., LISSENS, W.D., DE MOOR, P., BROSENS, I.A.·1980·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-51-6-1239
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Abstract

Peritoneal fluid was collected at laparoscopy in women during the menstrual cycle and was assayed for protein and steroid hormone content. The total protein concentration in peritoneal fluid and the concentrations of the steroid hormone-binding proteins, transcortin and sex hormone-binding globulin, the polypeptide hormones, LH, FSH, and PRL, correlated with the plasma concentration but were lower; they were, respectively, 68%, 71%, 68%, 42%, and 34% of the plasma concentration. The concentrations of steroid hormones secreted by the ovary, i.e. 17 beta-estradiol, progesterone, androstenedione, and testosterone, were always equal or higher in peritoneal fluid than in plasma. In contrast, the concentrations of cortisol, a nonovarian steroid hormone, was 40% lower in peritoneal fluid than in plasma. No cyclic variations were observed in the peritoneal fluid concentrations of androstenedione and testosterone, two steroid hormones secreted by the stromal component of the ovary. On the contrary, the concentrations of 17 beta-estradiol and progesterone secreted by the follicular apparatus of the ovary increased sharply in peritoneal fluid after ovulation, reaching values of 44000 pg/ml and 3000 ng/ml, respectively. They declined progressively, whereas in plasma, peak concentrations were achieved only in the midluteal phase. In conclusion, the concentrations of 17 beta-estradiol and progesterone are much higher in peritoneal fluid than in plasma for at least 1 week after ovulation. We suggest that the secretion of the early, not yet vascularized, corpus luteum is directed preferentially toward the peritoneal cavity, creating a specific hormonal environment for the released oocyte and the oviduct.

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Crossref · 10.1210/jcem-51-6-1239

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  • Estrogen and P concentrations in peritoneal fluid are much higher than in plasma, especially after ovulation.

    “Estrogen and P concentrations in PF (Supplemental Fig. 1) are much higher than in plasma, especially after ovulation (13).”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [13]

  • After ovulation, steroids are secreted predominantly into the peritoneal fluid from where they are resorbed into plasma.

    “It was calculated that after ovulation these steroids are secreted predominantly into the PF from where they are resorbed into plasma.”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [13]

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Authors
KONINCKX, P. R., VERHOEVEN, G., VAN BAELEN, H., LISSENS, W. D., DE MOOR, P., & BROSENS, I. A.
Affiliations
KU Leuven (BE)
ORCID
BROSENS, I.A.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1980-12
Volume
51
Issue
6
Pages
1239-1244
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-51-6-1239
OpenAlex
W2066417972
Cited by
101
References
22
Citations by year
2026: 4 · 2025: 3 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 3 · 2012: 2
FWCI
2.52
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
peritoneal fluid, menstrual cycle, estradiol, progesterone, corpus luteum, ovulation, corticosteroid-binding globulin, sex hormone-binding globulin, luteinizing hormone, follicle-stimulating hormone, prolactin, cortisol, ovarian steroid secretion, plasma hormone levels
MeSH terms
Ascitic Fluid, Electrolytes, Estradiol, Female, Gonadotropins, Pituitary, Humans, Hydrocortisone, Menstruation, Progesterone, Sex Hormone-Binding Globulin, Transcortin

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