The DOI matches its Crossref record.
Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects
Abstract
Serum melatonin concentrations were determined by RIA in 81 healthy humans, aged 1–92 yr. The daytime (0900–1100 h) serum levels of melatonin decreased progressively with advancing age. No sex difference was noted. The nocturnal rise of serum melatonin in the aged group was significantly reduced compared with that in the young group. These results suggest that serum melatonin may be secreted under the agerelated neural control of pineal metabolism.
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Citations
Cited by
Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629
Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide
Pappolla, M. A., Sos, M., Omar, R. A., Bick, R. J., Hickson-Bick, D. L. M., Reiter, R. J., Efthimiopoulos, S., & Robakis, N. K. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01683.1997 · Cited by 359
“On one hand, melatonin has a proposed physiological role in the aging process (Pierpaoli , 1991; Pierpaoli et al., 1991), and decreased secretion of melatonin with aging is documented (Iguchi et al., 1982; Dori et al., 1994).”
Background
Metadata
- Authors
- IGUCHI, H., KATO, K.-I., & IBAYASHI, H.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1982-07
- Volume
- 55
- Issue
- 1
- Pages
- 27-29
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2044510143
- Cited by
- 379
- References
- 0
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects. https://app.cochat.ai/papers/10.1210/jcem-55-1-27
- The paper
- IGUCHI, H., KATO, K.-I., & IBAYASHI, H. (1982). Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-55-1-27
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
