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Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects
Abstract
Serum melatonin concentrations were determined by RIA in 81 healthy humans, aged 1–92 yr. The daytime (0900–1100 h) serum levels of melatonin decreased progressively with advancing age. No sex difference was noted. The nocturnal rise of serum melatonin in the aged group was significantly reduced compared with that in the young group. These results suggest that serum melatonin may be secreted under the agerelated neural control of pineal metabolism.
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Citations
Cited by
Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629
Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide
Pappolla, M. A., Sos, M., Omar, R. A., Bick, R. J., Hickson-Bick, D. L. M., Reiter, R. J., Efthimiopoulos, S., & Robakis, N. K. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01683.1997 · Cited by 359
“On one hand, melatonin has a proposed physiological role in the aging process (Pierpaoli , 1991; Pierpaoli et al., 1991), and decreased secretion of melatonin with aging is documented (Iguchi et al., 1982; Dori et al., 1994).”
BackgroundLiu, R.-Y., Zhou, J.-N., van Heerikhuize, J., Hofman, M. A., & Swaab, D. F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5394 · Cited by 304
Melatonin treatment for age-related insomnia
Zhdanova, I. V., Wurtman, R. J., Regan, M. M., Taylor, J. A., Shi, J. P., & Leclair, O. U. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7901 · Cited by 308
Circadian rhythms of melatonin and cortisol in aging
Sharma, M., Palacios-Bois, J., Schwartz, G., Iskandar, H., Thakur, M., Quirion, R., & Nair, N. P. V. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90178-9 · Cited by 260
Do plasma melatonin concentrations decline with age?
Zeitzer, J. M., Daniels, J. E., Duffy, J. F., Klerman, E. B., Shanahan, T. L., Dijk, D.-J., & Czeisler, C. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00266-1 · Cited by 239
Diminished Melatonin Secretion in the Elderly Caused by Insufficient Environmental Illumination1
Mishima, K., Okawa, M., Shimizu, T., & Hishikawa, Y. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7097 · Cited by 218
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176
“Studies using melatonin have explored how shift work, particularly night work with its exposure to light at night, may increase the risk of cancer, aggravate both gastrointestinal and cardiovascular disease, complicate pregnancy, and interfere with drug therapy [68].”
BackgroundCircadian disruption and human health: A bidirectional relationship
Abbott, S. M., Malkani, R. G., & Zee, P. C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14298 · Cited by 161
Physiological melatonin levels in healthy older people: A systematic review
Scholtens, R. M., van Munster, B. C., van Kempen, M. F., & de Rooij, S. E. J. A. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.05.005 · Cited by 132
Chen, W. Y., Giobbie-Hurder, A., Gantman, K., Savoie, J., Scheib, R., Parker, L. M., & Schernhammer, E. S. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-2944-4 · Cited by 130
Ha, E., Yim, S., Chung, J., Yoon, K., Kang, I., Cho, Y. H., & Baik, H. H. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00334.x · Cited by 124
Silva, E. J., Wang, W., Ronda, J. M., Wyatt, J. K., & Duffy, J. F. (2010) · Sleep · doi:10.1093/sleep/33.4.481 · Cited by 114
The Role of Melatonin in the Treatment of Primary Headache Disorders
Gelfand, A. A., & Goadsby, P. J. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12862 · Cited by 95
Metadata
- Authors
- IGUCHI, H., KATO, K.-I., & IBAYASHI, H.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1982-07
- Volume
- 55
- Issue
- 1
- Pages
- 27-29
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2044510143
- Cited by
- 379
- References
- 0
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
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