The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Osteocalcin in Human Serum: A Circadian Rhythm*
Abstract
Osteocalcin, the vitamin K-dependent protein synthesized in bone, is found in blood. The level of circulating osteocalcin has recently been used as an indicator of the rate of bone turnover. We measured serum osteocalcin during 24-h periods in 6 normal 20- to 30-yr-old men and 4 women. Blood was sampled via an indwelling venous catheter every 30 or 60 min for 24 h. Circadian rhythmicity in circulating osteocalcin was found in 9 of the 10 individuals studied. Osteocalcin levels fell during the morning, rose in the afternoon and early evening, and reached a peak nocturnally. There were no consistent correlations between osteocalcin concentrations and circulating levels of ionized calcium, total calcium, or inorganic phosphate in the subjects tested. This study illustrates the importance of regulating the time of blood sampling for osteocalcin determinations in clinical investigations of metabolic bone disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Characterization of a gamma-carboxyglutamic acid-containing protein from bone.
Price, P. A., Otsuka, A. A., Poser, J. W., Kristaponis, J., & Raman, N. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.5.1447 · Cited by 787
Hauschka, P. V., Lian, J. B., & Gallop, P. M. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.10.3925 · Cited by 747
Price, P. A., Parthemore, J. G., & Deftos, L. J. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109954 · Cited by 657
Price, P. A., & Baukol, S. A. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70182-3 · Cited by 500
Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone.
Price, P. A., Williamson, M. K., & Lothringer, J. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42960-2 · Cited by 485
Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma.
Price, P. A., & Nishimoto, S. K. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.2234 · Cited by 427
Jubiz, W., Canterbury, J. M., Reiss, E., & Tyler, F. H. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107010 · Cited by 264
DIFFERENCES IN SERUM BONE GLA PROTEIN WITH AGE AND SEX
Epstein, S., Mcclintock, R., Bryce, G., Poser, J., Johnston, C., & Hui, S. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90360-x · Cited by 194
Clinical Evaluation of Bone Turnover by Serum Osteocalcin Measurements in a Hospital Setting*
SLOVIK, D. M., GUNDBERG, C. M., NEER, R. M., & LIAN, J. B. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-2-228 · Cited by 180
Self-citationChanges in plasma bone GLA protein during treatment of bone disease
Deftos, L. J., Parthemore, J. G., & Price, P. A. (1982) · Calcified Tissue International · doi:10.1007/bf02411221 · Cited by 163
Cited by
The Molecular Clock Mediates Leptin-Regulated Bone Formation
Fu, L., Patel, M. S., Bradley, A., Wagner, E. F., & Karsenty, G. (2005) · Cell · doi:10.1016/j.cell.2005.06.028 · Cited by 578
Lee, A. J., Hodges, S., & Eastell, R. (2000) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/000456320003700402 · Cited by 295
Aplastic osteodystrophy without aluminum: The role of “suppressed” parathyroid function
Hercz, G., Pei, Y., Greenwood, C., Manuel, A., Saiphoo, C., Goodman, W. G., Segre, G. V., Fenton, S., & Sherrard, D. J. (1993) · Kidney International · doi:10.1038/ki.1993.323 · Cited by 281
Knapen, M. H. J., Hamulyák, K., & Vermeer, C. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-12-1001 · Cited by 271
Regulation of bone remodeling by the central and peripheral nervous system
Elefteriou, F. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.016 · Cited by 229
Metadata
- Authors
- GUNDBERG, C. M., MARKOWITZ, M. E., MIZRUCHI, M., & ROSEN, J. F.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1985-04
- Volume
- 60
- Issue
- 4
- Pages
- 736-739
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2083279848
- Cited by
- 261
- References
- 16
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Osteocalcin in Human Serum: A Circadian Rhythm*. https://app.cochat.ai/papers/10.1210/jcem-60-4-736
- The paper
- GUNDBERG, C. M., MARKOWITZ, M. E., MIZRUCHI, M., & ROSEN, J. F. (1985). Osteocalcin in Human Serum: A Circadian Rhythm*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-60-4-736
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
