The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Effect of Vitamin K Supplementation on Circulating Osteocalcin (Bone Gla Protein) and Urinary Calcium Excretion
Abstract
STUDY OBJECTIVE: To determine whether vitamin K administration affects urinary calcium excretion in postmenopausal women. DESIGN: Before- and after-trials with a 2-week treatment period. SUBJECTS: Healthy postmenopausal women (55 to 75 years old) were recruited from the convents in and around Maastricht. Controls (25 to 40 years old) were healthy premenopausal volunteers. INTERVENTION: Daily administration of 1 mg of vitamin K for 2 weeks. MEASUREMENTS: Serum immunoreactive osteocalcin: hydroxylapatite binding (HAB) capacity of serum immunoreactive osteocalcin; excretion of calcium, hydroxyproline, and creatinine in the urine during the last 2 h of a 16-h fasting period. RESULTS: In premenopausal women, no effect of vitamin K administration was seen. In the postmenopausal group, vitamin K induced increased serum immunoreactive osteocalcin concentration; normalization of the HAB capacity of serum immunoreactive osteocalcin (this marker was less than 50% that of the controls in the pretreatment samples); a decrease in urinary calcium excretion, notably in the "fast losers" of calcium; and a parallel decrease in urinary hydroxyproline excretion in the fast losers of calcium. CONCLUSIONS: The serum immunoreactive osteocalcin level may vary with vitamin K status. This variance should be taken into consideration if osteocalcin is used as a marker for osteoblast activity. Vitamin K is one factor that may play a role in the loss of bone mass in postmenopausal osteoporosis.
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Cites
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VITAMIN K-DEPENDENT CARBOXYLASE
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Price, P. A., Urist, M. R., & Otawara, Y. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91663-7 · Cited by 357
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Osteocalcin in Human Serum: A Circadian Rhythm*
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Cited by
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Vitamin K intake and hip fractures in women: a prospective study
Feskanich, D., Weber, P., Willett, W. C., Rockett, H., Booth, S. L., & Colditz, G. A. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.1.74 · Cited by 484
Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women.
Szulc, P., Chapuy, M. C., Meunier, P. J., & Delmas, P. D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116387 · Cited by 484
Journal of Bone and Mineral Research
Delmas, P. D. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650081323 · Cited by 454
Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease
Greenblatt, M. B., Tsai, J. N., & Wein, M. N. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.259085 · Cited by 376
Metadata
- Authors
- Knapen, M. H. J., Hamulyák, K., & Vermeer, C.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1989-12-15
- Volume
- 111
- Issue
- 12
- Pages
- 1001-1005
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2044545913
- Cited by
- 271
- References
- 20
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Knapen, M. H. J., Hamulyák, K., & Vermeer, C. (1989). The Effect of Vitamin K Supplementation on Circulating Osteocalcin (Bone Gla Protein) and Urinary Calcium Excretion. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-111-12-1001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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