The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Circadian Rhythms of Epinephrine and Norepinephrine in Man*
Abstract
The diurnal rhythms of plasma epinephrine and norepinephrine were investigated in a group of normal young men. Sleep, posture, illumination, and food intake were monitored. Plasma epinephrine demonstrated a statistically significant diurnal rhythm, with a mean amplitude of 14 +/- 1.6 (+/- SE) pg/ml superimposed on a mean level of 43 +/- 5.3 pg/ml. The trough occurred at 03.20 h +/- 35 min. Plasma norepinephrine had a significant diurnal rhythm, with a mean amplitude of 111 +/- 19 pg/ml superimposed on a mean level of 413 +/- 25 pg/ml, with the trough occurring at 02.20 h +/- 30 min. There was a significant correlation between the two rhythms at zero phase shift, with a pooled value for the group of r = 0.49. Epinephrine levels had no direct relationship to sleep or posture, whereas norepinephrine levels were significantly higher with upright posture and higher when the men were awake than when asleep. Our results indicate that circadian variations in the sympathetic-adrenal medullary system are not explained by a single controlling influence and that the norepinephrine rhythm can be accounted for as a direct response to changes in posture and sleep, whereas the epinephrine rhythm is probably controlled by a circadian oscillator.
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“In a small study of eight lean males, plasma catecholamines were consistently lower during the night with no differences among sleep stages (Fig. 2).73”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [73]
Citations
Cites
Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Robust Locally Weighted Regression and Smoothing Scatterplots
Cleveland, W. S. (1979) · Journal of the American Statistical Association · doi:10.1080/01621459.1979.10481038 · Cited by 11,594
On Methods in the Analysis of Profile Data
Greenhouse, S. W., & Geisser, S. (1959) · Psychometrika · doi:10.1007/bf02289823 · Cited by 4,946
Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man
Lake, C., Ziegler, M. G., & Kopin, I. J. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90210-1 · Cited by 548
Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
Robertson, D., Johnson, G., Robertson, R. M., Nies, A. S., Shand, D. G., & Oates, J. A. (1979) · Circulation · doi:10.1161/01.cir.59.4.637 · Cited by 467
Turton, M. B., & Deegan, T. (1974) · Clinica Chimica Acta · doi:10.1016/0009-8981(74)90014-x · Cited by 322
Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man
WALLIN, B. G., SUNDLÖF, G., ERIKSSON, B., DOMINIAK, P., GROBECKER, H., & LINDBLAD, L. E. (1981) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1981.tb06706.x · Cited by 316
Prinz, P. N., Halter, J. B., Benedetti, C., & Raskind, M. A. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-2-300 · Cited by 185
von Euler, U. S., Hellner-Bjorkman, S., & Orwen, I. (1955) · PubMed · Cited by 150
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Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632
Circadian Variation in Vascular Tone and Its Relation to α-Sympathetic Vasoconstrictor Activity
Panza, J. A., Epstein, S. E., & Quyyumi, A. A. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110033251402 · Cited by 607
Circadian clock control of endocrine factors
Gamble, K. L., Berry, R., Frank, S. J., & Young, M. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.78 · Cited by 539
How to assess sympathetic activity in humans
Grassi, G., & Esler, M. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917060-00001 · Cited by 455
Metadata
- Authors
- LINSELL, C. R., LIGHTMAN, S. L., MULLEN, P. E., BROWN, M. J., & CAUSON, R. C.
- Affiliations
- University of Otago (NZ)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1985-06
- Volume
- 60
- Issue
- 6
- Pages
- 1210-1215
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1976632402
- Cited by
- 399
- References
- 24
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 14 · 2020: 13 · 2019: 3 · 2018: 8 · 2017: 17 · 2016: 13 · 2015: 10 · 2014: 7 · 2013: 11 · 2012: 12
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- circadian rhythm, diurnal variation, plasma epinephrine, plasma norepinephrine, sympathoadrenal system, sleep, posture, upright posture, circadian clock, dietary intake
- MeSH terms
- Blood Specimen Collection, Circadian Rhythm, Eating, Epinephrine, Humans, Male, Norepinephrine, Posture, Sleep
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