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Cited by 307

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*

HOLLENBECK, CLARIE, REAVEN, GERALD M.·1987·The Journal of Clinical Endocrinology & Metabolism

Abstract

Measurements were made of both glucose disposal (M) during hyperinsulinemic clamp studies and plasma glucose and insulin responses to an oral glucose challenge in 100 individuals with normal glucose tolerance. The subjects were divided into 4 quartiles on the basis of M values, ranging from a low mean (+/- SEM) value of 140 +/- 3 mg/m2 X min (quartile 1) to a high of 349 mg/m2 X min (quartile 4). The plasma insulin response to oral glucose inversely correlated with the M value (r = -0.60; P less than 0.001), being highest in those with the lowest M (quartile 1) and lowest in those with the highest M (quartile 4). On the other hand, the plasma glucose responses of the 4 quartiles were virtually identical. These results document that insulin-stimulated glucose uptake varies widely in subjects with normal glucose tolerance, and that these differences are independent of any change in the plasma glucose response to oral glucose. Furthermore, the results indicate that insulin resistance in normal individuals is associated with hyperinsulinemia.

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Metadata

Authors
HOLLENBECK, C., & REAVEN, G. M.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
1987-06
Volume
64
Issue
6
Pages
1169-1173
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W1975896994
Cited by
307
References
36
FWCI
6.46
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*. https://app.cochat.ai/papers/10.1210/jcem-64-6-1169
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HOLLENBECK, C., & REAVEN, G. M. (1987). Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-64-6-1169

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.