The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*
Abstract
Measurements were made of both glucose disposal (M) during hyperinsulinemic clamp studies and plasma glucose and insulin responses to an oral glucose challenge in 100 individuals with normal glucose tolerance. The subjects were divided into 4 quartiles on the basis of M values, ranging from a low mean (+/- SEM) value of 140 +/- 3 mg/m2 X min (quartile 1) to a high of 349 mg/m2 X min (quartile 4). The plasma insulin response to oral glucose inversely correlated with the M value (r = -0.60; P less than 0.001), being highest in those with the lowest M (quartile 1) and lowest in those with the highest M (quartile 4). On the other hand, the plasma glucose responses of the 4 quartiles were virtually identical. These results document that insulin-stimulated glucose uptake varies widely in subjects with normal glucose tolerance, and that these differences are independent of any change in the plasma glucose response to oral glucose. Furthermore, the results indicate that insulin resistance in normal individuals is associated with hyperinsulinemia.
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Citations
Cites
Immunoassay of insulin with insulin-antibody precipitate
HALES, C., & RANDLE, P. (1963) · Biochemical Journal · doi:10.1042/bj0880137 · Cited by 2,638
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,670
Klockars, A., & Sax, G. (1986) · Sage eBooks · doi:10.4135/9781412985185 · Cited by 1,013
A New and Rapid Method for the Determination of Glucose by Measurement of Rate of Oxygen Consumption
Kadish, A. H., Litle, R. L., & Sternberg, J. C. (1968) · Clinical Chemistry · doi:10.1093/clinchem/14.2.116 · Cited by 740
Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.
Kolterman, O. G., Insel, J., Saekow, M., & Olefsky, J. M. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109790 · Cited by 664
Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin
DeFronzo, R. A. (1979) · Diabetes · doi:10.2337/diab.28.12.1095 · Cited by 595
Mechanisms of Insulin Resistance in Aging
Fink, R. I., Kolterman, O. G., Griffin, J., & Olefsky, J. M. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110908 · Cited by 555
Shen, S.-W., Reaven, G. M., & Farquhar, J. W. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106433 · Cited by 494
Self-citationUnger, R. H., & Grundy, S. (1985) · Diabetologia · doi:10.1007/bf00273856 · Cited by 452
Bogardus, C., Lillioja, S., Howard, B. V., Reaven, G., & Mott, D. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111533 · Cited by 397
Self-citation
Cited by
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Self-citationSubcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
McKeigue, P. M., Shah, B., & Marmot, M. G. (1991) · The Lancet · doi:10.1016/0140-6736(91)91164-p · Cited by 1,618
Metadata
- Authors
- HOLLENBECK, C., & REAVEN, G. M.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1987-06
- Volume
- 64
- Issue
- 6
- Pages
- 1169-1173
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1975896994
- Cited by
- 307
- References
- 36
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- HOLLENBECK, C., & REAVEN, G. M. (1987). Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-64-6-1169
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.