The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Effect of Vitamin D Supplementation on Vitamin D Status and Parathyroid Function in Elderly Subjects*
Abstract
Vitamin D deficiency is common in the elderly and may lead to secondary hyperparathyroidism, cortical bone loss, and hip fractures. The effect of vitamin D supplementation for 1 yr was studied in 72 people living in a nursing home and 70 people living in an aged people's home. The subjects were randomized into 3 groups: control, and 400 or 800 IU vitamin D3/day. The initial vitamin D status of each subject was classified as deficient or borderline [serum 25-hydroxyvitamin D (25OHD) less than 30 nmol/L] in 79% and adequate (serum 25OHD greater than or equal to 30 nmol/L) in 21%. Serum 25OHD concentrations increased about 3-fold in both groups receiving vitamin D supplementation. Serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations increased slightly but significantly, and the increase was inversely related to the initial serum 25OHD concentration. Serum intact PTH-(1-84) concentrations decreased about 15% during supplementation in both nursing home and aged people's home residents, whereas serum osteocalcin significantly decreased in the nursing home residents only. We conclude that a vitamin D3 supplement of 400 IU/day adequately improves vitamin D status in elderly people and increases 1,25-(OH)2D concentrations in those with vitamin D deficiency. Supplementation decreases parathyroid function and may depress bone turnover to some degree.
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Citations
Cites
Experimental Design: Procedures for the Behavioral Sciences
Kirk, R. (2013) · doi:10.4135/9781483384733 · Cited by 8,539
Cited by
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Bischoff-Ferrari, H. A., Giovannucci, E., Willett, W. C., Dietrich, T., & Dawson-Hughes, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.18 · Cited by 2,414
Nesby-O’Dell, S., Scanlon, K. S., Cogswell, M. E., Gillespie, C., Hollis, B. W., Looker, A. C., Allen, C., Doughertly, C., Gunter, E. W., & Bowman, B. A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.187 · Cited by 1,001
Vitamin D supplementation for prevention of mortality in adults
Bjelakovic, G., Gluud, L. L., Nikolova, D., Whitfield, K., Wetterslev, J., Simonetti, R. G., Bjelakovic, M., & Gluud, C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007470.pub3 · Cited by 695
Which circulating level of 25-hydroxyvitamin D is appropriate?
Lips, P. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.040 · Cited by 347
Self-citationKrall, E. A., Sahyoun, N., Tannenbaum, S., Dallal, G. E., & Dawson-Hughes, B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912283212602 · Cited by 345
Metadata
- Authors
- LIPS, P., WIERSINGA, A., VAN GINKEL, F. C., JONGEN, M. J. M., NETELENBOS, J. C., HACKENG, W. H. L., DELMAS, P. D., & VAN DER VIJGH, W. J. F.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1988-10
- Volume
- 67
- Issue
- 4
- Pages
- 644-650
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2112272583
- Cited by
- 377
- References
- 1
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Effect of Vitamin D Supplementation on Vitamin D Status and Parathyroid Function in Elderly Subjects*. https://app.cochat.ai/papers/10.1210/jcem-67-4-644
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- LIPS, P., WIERSINGA, A., VAN GINKEL, F. C., JONGEN, M. J. M., NETELENBOS, J. C., HACKENG, W. H. L., DELMAS, P. D., & VAN DER VIJGH, W. J. F. (1988). The Effect of Vitamin D Supplementation on Vitamin D Status and Parathyroid Function in Elderly Subjects*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-67-4-644
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
