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Cited by 126Hormonal and reproductive studiesMuscle metabolism and nutritionAdrenal Hormones and Disorders

Failure of dehydroepiandrosterone to influence energy and protein metabolism in humans.

WELLE, STEPHEN, JOZEFOWICZ, RALPH, STATT, MARCIA·1990·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-71-5-1259
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Abstract

It was reported recently that 4 weeks of dehydroepiandrosterone (DHEA) treatment [5.55 mmol/day (1600 mg/day), orally] reduced body fat and increased lean body mass in healthy men. The present study was performed to examine whether these effects could be explained by increased energy expenditure and muscle protein synthesis. Eight healthy men were given placebo and DHEA (1600 mg/day) for 4 weeks each in a double blind cross-over study. DHEA treatment caused a 9-fold increase in mean plasma DHEA sulfate concentrations, but had no significant effect on body weight or on two indices of lean body mass (total body water and total body potassium). DHEA had no effect on any of the parameters of energy and protein metabolism, including resting metabolic rate, total energy expenditure (estimated by the 2H2(18)O method during the final 2 weeks of each treatment period), leucine flux (an index of whole body proteolysis), the nonoxidized portion of leucine flux (an index of whole body protein synthesis), and the rate of incorporation of leucine into muscle protein. Circulating levels of cholesterol, T3, and T4 also were unaffected by DHEA. These data suggest that DHEA is not an important regulator of energy or protein metabolism in humans.

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Authors
WELLE, S., JOZEFOWICZ, R., & STATT, M.
Affiliations
University of Rochester Medicine (US)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1990-11
Volume
71
Issue
5
Pages
1259-1264
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-71-5-1259
OpenAlex
W2001094153
Cited by
126
References
6
Citations by year
2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 1
FWCI
3.47
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01dk039063-01, 5r01ns022099-11)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-39063)
  • National Institute of Neurological Disorders and Stroke (NS-22099)
  • National Center for Research Resources (RR-00044, M01RR000044)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
dehydroepiandrosterone, energy metabolism, protein metabolism, muscle protein synthesis, leucine flux, resting metabolic rate, total energy expenditure, DHEA sulfate, lean body mass, fat mass, proteolysis, healthy men
MeSH terms
Adult, Basal Metabolism, Cholesterol, Dehydroepiandrosterone, Energy Metabolism, Female, Humans, Muscle Proteins, Muscles, Thyroid Hormones

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