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Cited by 105Hormonal and reproductive studiesAdrenal Hormones and DisordersMenopause: Health Impacts and Treatments

Dehydroepiandrosterone Supplementation in Elderly Men: A Meta-Analysis Study of Placebo-Controlled Trials

Corona, Giovanni, Rastrelli, Giulia, Giagulli, Vito A., Sila, Annamaria, Sforza, Alessandra, Forti, Gianni, Mannucci, Edoardo, Maggi, Mario·2013·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2013-1358
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Abstract

Context Age-related dehydroepiandrosterone (DHEA) deficiency has been associated with a broad range of biological abnormalities in males. Object Our objective was to meta-analyze all double-blind, placebo-controlled randomized trials (RCTs) investigating the effect of oral DHEA (DHEA supplementation) in comparison with placebo on sexual and metabolic outcomes in elderly men. Data source An extensive Medline Embase and Cochrane search was performed including the following words: DHEA, RCTs, and males. Study selection Only double-blind placebo-controlled trials performed in elderly men were included. Data extraction Data extraction was performed independently by 2 of the authors (A.S. and V.G.), and conflicts were resolved by the third investigator (G.C.). The quality of RCTs was assessed using the Cochrane criteria. Results Of 220 retrieved articles, 25 were included in the study. The available RCTs enrolled 1353 elderly men, with a mean follow-up of 36 weeks. DHEA supplementation was associated with a reduction of fat mass (standardized mean difference of -0.35 [-0.65 to -0.05]; P = .02). However, the association with fat mass disappeared in a multivariate regression model after adjusting for DHEA-related metabolite increases such as total testosterone and estradiol. In contrast to what was observed for fat mass, no effect of DHEA supplementation in comparison with placebo was observed for various clinical parameters including lipid and glycemic metabolism, bone health, sexua…

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  • A 2013 meta-analysis of 25 randomized controlled trials studying DHEA in over 1,300 men found DHEA supplementation associated with small improvements in body fat composition, but no improvements in total serum testosterone, glucose or lipid profiles, bone mineral density, or mental or physical quality of life outcomes.

    “A 2013 meta-analysis of 25 randomized controlled trials studying DHEA use in over 1,300 men found that DHEA supplementation was associated with small improvements in body fat composition, but no improvements were noted in total serum testosterone, glucose or lipid profiles, bone mineral density, or mental or physical quality of life outcomes (38).”

    From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [38]

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Authors
Corona, G., Rastrelli, G., Giagulli, V. A., Sila, A., Sforza, A., Forti, G., Mannucci, E., & Maggi, M.
Affiliations
  • Ospedale Bellaria (IT)
  • University of Florence (IT)
  • Azienda Ospedaliero-Universitaria Careggi (IT)
Corresponding author
Maggi, Mario
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2013-09
Volume
98
Issue
9
Pages
3615-3626
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2013-1358
OpenAlex
W1975009246
Cited by
105
References
64
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 26 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 15 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 3
FWCI
6.03
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
dehydroepiandrosterone, DHEA supplementation, older men, fat mass, body composition, testosterone, estradiol, sexual function, bone health, lipid metabolism, glucose metabolism, quality of life
MeSH terms
Aged, Body Composition, Bone and Bones, Dehydroepiandrosterone, Humans, Male, Controlled Clinical Trials as Topic, Dietary Supplements, Hormone Replacement Therapy

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