The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Pituitary Size in Depression*
Abstract
Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.
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“For example Krishnan et al. (1991) showed that MRI-based measures of cross-sectional area and volume of the pituitary were increased (by 34 and 41%, respectively) in depressives versus controls.”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Krishnan et al. (1991)
Citations
Cites
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243
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Self-citationPsychiatric implications of basic and clinical studies with corticotropin-releasing factor.
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Development and aging of brain midline structures: assessment with MR imaging.
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Westlund, K. N., Aguilera, G., & Childs, G. V. (1985) · Endocrinology · doi:10.1210/endo-116-1-439 · Cited by 99
Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment
von Bardeleben, U., Stalla, G. K., Müller, O. A., & Holsboer, F. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90254-5 · Cited by 81
Lisansky, J. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810070067011 · Cited by 72
Doraiswamy, P. M., Krishnan, K. R. R., Figiel, G. S., Husain, M. M., Boyko, O. B., Rockwell, W. J. K., & Ellinwood, E. H. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90628-f · Cited by 68
Self-citationMagnetic Resonance Imaging of Pituitary and Parasellar Abnormalities
Chakeres, D. W., Curtin, A., & Ford, G. (1989) · Radiologic Clinics of North America · doi:10.1016/s0033-8389(22)00875-2 · Cited by 65
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Items 201–230 of 230
Hornig, M., & Amsterdam, J. D. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg05 · Cited by 1
McEwen, B. S. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg19 · Cited by 1
Neurogenic and angiogenic actions of electroconvulsive seizures in adult rat brain
Hellsten, J. (2005) · Lund University Publications (Lund University)
Orre, K. (2013) · Lund University Publications (Lund University)
Increased Pituitary Volume in …Psychosis Study
Doraiswamy, P. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300903
Self-citationPsikiyatrik Hastaliklarda Radyolojik Görüntüleme: Yeni Gelişmeler
Imaging, R. (2010)
The Hypothalamic–Pituitary–Adrenal Axis in Bipolar Disorder
Bond, D. J., & Young, A. H. (2007) · CRC Press eBooks · doi:10.3109/9781420021158-11
Hanumegowda, R. K., & Brahmaroutu, K. (2016) · Journal of Evidence Based Medicine and Healthcare · doi:10.18410/jebmh/2016/1115
Neuroimaging in Seasons and Winter Depression
Spindelegger, C., Willeit, M., Praschak-Rieder, N., Lanzenberger, R. R., & Kasper, S. F. (2014) · Springer eBooks · doi:10.1007/978-3-642-40384-2_8
Benabarre, A. (2003) · Revista de Psiquiatría de la Facultad de Medicina de Barcelona
(1991) · The Lancet · doi:10.1016/0140-6736(91)93266-c
Verändertes Verhältnis von TSΗ zu ACTH bei depressiven männlichen Patienten
Schaaf, L., Peteranderl, C., Antonijevic, I. A., Kreppold, E., Steiger, A., Stalla, G. K., & Holsboer, F. (2000) · De Gruyter eBooks · doi:10.1515/9783110812282.234
Jensen, I. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9601
Chapter 9. Dehydroepiandrosterone in Psychoneuroendocrinology
Wolkowitz, O. M., & Reus, V. I. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg09
Chapter 14. Thyroid Function in Psychiatric Disorders
O’Connor, D. H., Gwirtsman, H. E., & Loosen, P. T. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg14
Chapter 12. Clinical Psychotropic Effects of Gonadal Hormone Medications in Women
Halbreich, U. M., Wamback, S. J., & Kahn, L. S. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg12
Chapter 16. Thyroid Hormone Treatment of Psychiatric Disorders
Sokolov, S. T. H., & Joffe, R. T. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg16
Chapter 4. Chronobiology and Melatonin
Sack, R. L., Lewy, A. J., Rittenbaum, M., & Hughes, R. J. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg04
Chapter 11. Endogenous Gonadal Hormones in Postpartum Psychiatric Disorders
Weinstock, L., & Cohen, L. S. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg11
Chapter 18. Endocrine Imaging in Depression
Gadde, K. M., & King, R. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg18
Chapter 1. Introduction and Overview
Wolkowitz, O. M., & Rothschild, A. J. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg01
Chapter 17. Laboratory Evaluation of Neuroendocrine Systems
Michelson, D., & Gold, P. W. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg17
Chapter 2. Historical Roots of Psychoneuroendocrinology
Lindley, S. E., & Schatzberg, A. F. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg02
Chapter 10. Menstrual Cycle–Related and Perimenopause-Related Affective Disorders
Rubinow, D. R., & Schmidt, P. J. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg10
Erbe, S. (2009) · Qucosa (Saxon State and University Library Dresden)
Metadata
- Authors
- KRISHNAN, K. R. R., DORAISWAMY, P. M., LURIE, S. N., FIGIEL, G. S., HUSAIN, M. M., BOYKO, O. B., ELLINWOOD, E. H., & NEMEROFF, C. B.
- Affiliations
- Duke University (US)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1991-02
- Volume
- 72
- Issue
- 2
- Pages
- 256-259
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2051225255
- Cited by
- 232
- References
- 9
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 6
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh044716-06)
- National Institute of Mental Health (R01MH042088, MH-44716, MH 40159, MH42088)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- major depressive disorder, pituitary volume, pituitary stalk, brain structural changes, geriatric depression, neuroimaging of depression
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Pituitary Gland
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