Cited by 232Stress Responses and CortisolTreatment of Major DepressionPituitary Gland Disorders and Treatments

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Pituitary Size in Depression*

KRISHNAN, K. RANGA RAMA, DORAISWAMY, P. MURALI, LURIE, SCOTT N., FIGIEL, GARY S., HUSAIN, MUSTAFA M., BOYKO, OREST B., ELLINWOOD, EVERETT H., NEMEROFF, CHARLES B.·1991·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-72-2-256

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Abstract

Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

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Authors: KRISHNAN, K. R. R., DORAISWAMY, P. M., LURIE, S. N., FIGIEL, G. S., HUSAIN, M. M., BOYKO, O. B., ELLINWOOD, E. H., & NEMEROFF, C. B.
Affiliations: Duke University (US)
ORCID: KRISHNAN, K. RANGA RAMA
DORAISWAMY, P. MURALI
HUSAIN, MUSTAFA M.
BOYKO, OREST B.
NEMEROFF, CHARLES B.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1991-02
Volume: 72
Issue: 2
Pages: 256-259
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-72-2-256
OpenAlex: W2051225255
Cited by: 232
References: 9
Citations by year: 2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 6
FWCI: 4.74
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh044716-06)
National Institute of Mental Health (R01MH042088, MH-44716, MH 40159, MH42088)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: major depressive disorder, pituitary volume, pituitary stalk, brain structural changes, geriatric depression, neuroimaging of depression
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Pituitary Gland

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