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Cited by 185Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization

Weissberger, A J, Ho, K K·1993·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.76.6.8501143
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Abstract

To determine whether testosterone modulates the somatotropic axis in adult males, we compared 24-h GH secretion (from 20-min sampling, using Cluster analysis) and insulin-like growth factor-I (IGF-I) levels of five hypogonadal men (aged 20-32 yr) with those of six normal men (aged 21-27 yr), and examined the effects of testosterone replacement (testosterone enanthate 250 mg im monthly). To elucidate whether the action of testosterone on the somatotropic axis is direct, or requires the aromatization of testosterone to estradiol, we also examined the effects of the nonsteroidal antiestrogen, tamoxifen (20 mg/day for 3 weeks), on 24-h GH secretion and IGF-I levels in the normal men and in four of the hypogonadal men during concurrent testosterone treatment. Compared to the normal men, the hypogonadal men had significantly reduced mean GH pulse amplitude (3.1 +/- 0.6 vs. 8.4 +/- 1.7 micrograms/L, P < 0.05), but not pulse frequency. Testosterone treatment resulted in a significant increase in 24-h mean serum GH (0.7 +/- 0.2 to 1.4 +/- 0.2 micrograms/L, P < 0.05), mean GH pulse amplitude (3.1 +/- 0.6 to 5.2 +/- 0.8 micrograms/L, P < 0.01) and serum IGF-I (0.9 +/- 0.1 to 1.1 +/- 0.1 U/mL, P < 0.05). In the normal men, tamoxifen significantly reduced 24-h mean serum GH (1.1 +/- 0.3 to 0.5 +/- 0.1 micrograms/L, P < 0.05), mean GH pulse amplitude (8.4 +/- 1.7 to 4.7 +/- 0.4 micrograms/L, P < 0.05), and serum IGF-I (1.0 +/- 0.1 to 0.7 +/- 0.1 U/mL, P < 0.001). In the hypogonadal men on…

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Crossref · 10.1210/jcem.76.6.8501143

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Metadata

Authors
Weissberger, A. J., & Ho, K. K.
Affiliations
Garvan Institute of Medical Research (AU)
ORCID
Ho, K K
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1993-06
Volume
76
Issue
6
Pages
1407-1412
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.76.6.8501143
OpenAlex
W2062033941
Cited by
185
References
32
Citations by year
2024: 4 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
4.51
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
somatotropic axis, testosterone, hypogonadism, growth hormone secretion, insulin-like growth factor I, aromatization, estradiol, tamoxifen, antiestrogens, testosterone replacement therapy, adult male
MeSH terms
Adult, Humans, Hypogonadism, Male, Osmolar Concentration, Reference Values, Growth Hormone, Tamoxifen, Testosterone

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