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Cited by 204Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesHuman Health and Disease

Somatomedins in adolescence: a cross-sectional study of the effect of puberty on plasma insulin-like growth factor I and II levels

LUNA, ALICE M., WILSON, DARRELL M., WIBBELSMAN, CHARLES J., BROWN, RICHARD C., NAGASHIMA, RAYMOND J., HINTZ, RAYMOND L., ROSENFELD, RON G.·1983·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-57-2-268
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Abstract

To explore the effect of puberty on the somatomedins (SMs), a group of insulin-like peptides which mediate the action of GH on skeletal tissue, we measured SM-C/insulin-like growth factor-I (SM-C/IGF-I) and IGF-II by specific RIAs in 110 adolescents between the ages of 10 and 18 yr. All subjects were in good health and between the 5th and 95th percentiles for height. In both females and males, SM-C/IGF-I levels rose during puberty to a peak approximately 3-fold higher than the average adult level. The rise in SM-C/IGF-I levels corresponded better with the Tanner stage of the adolescents than with their chronological age. IGF-II levels did not rise during puberty and were slightly below adult levels. The dramatic rise in SM-C/IGF-I levels during puberty suggests a role for this SM peptide in the adolescent growth spurt. Furthermore, these data indicate that proper interpretation of SM-C/IGF-I levels during adolescence must include a knowledge of the patient's pubertal development.

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Crossref · 10.1210/jcem-57-2-268

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  • Studies show an increase in IGF-1 expression during puberty in human beings.

    “Moreover, studies show an increase in IGF-1 expression during puberty in human beings.109”

    From Pubertal development and regulation (2016) · cites this paper as [109]

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Authors
LUNA, A. M., WILSON, D. M., WIBBELSMAN, C. J., BROWN, R. C., NAGASHIMA, R. J., HINTZ, R. L., & ROSENFELD, R. G.
Affiliations
San Francisco General Hospital (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1983-08
Volume
57
Issue
2
Pages
268-271
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-57-2-268
OpenAlex
W2159795530
Cited by
204
References
19
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 1 · 2014: 6 · 2013: 1 · 2012: 3
FWCI
12.69
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Human Health and Disease
Keywords
insulin-like growth factor, insulin-like growth factor I, insulin-like growth factor II, puberty, adolescents, growth spurt, plasma IGF-I levels, Tanner stages, growth hormone, skeletal development
MeSH terms
Adolescent, Aging, Child, Cross-Sectional Studies, Female, Humans, Insulin, Male, Peptides, Puberty, Somatomedins

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