CoChat
Sign Up
Cited by 228Adrenal Hormones and DisordersStress Responses and CortisolHormonal and reproductive studies

Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis

Kerrigan, J R, Veldhuis, J D, Leyo, S A, Iranmanesh, A, Rogol, A D·1993·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.76.6.8501158
Open this paper in CoChat — free account

Abstract

To investigate daily cortisol production and clearance rates in a group (n = 18) of normal unstressed pubertal males, we applied deconvolution analysis to serum cortisol concentrations obtained every 20 min for 24 h. Subject-specific characterization of adrenocortical secretory episodes, cortisol production rate, and serum hormone half-life for nine early pubertal (Tanner I or II; early) and nine late pubertal (Tanner IV or V; late) subjects was undertaken to assess potential roles of sexual maturation and changing gonadal steroid hormone concentrations on glucocorticoid physiology. The estimated cortisol production rate for the early group [16.8 +/- 1.3 mumol/m2 x day (6.1 +/- 0.4 mg/m2 x day)] was indistinguishable from that of the late subjects [14.8 +/- 1.4 mumol/m2 x day (5.3 +/- 0.5 mg/m2 x day)]. No differences were observed between the two pubertal groups in the secretory burst frequency and half-duration, mass of cortisol released per secretory episode, average maximal rate of hormone secretion, and serum cortisol half-life. A significant diurnal pattern of cortisol secretion was observed for all subjects manifest by nyctohemeral variations in the frequency of adrenocortical secretory bursts, the amplitude (maximal rate of cortisol secretion) and the mass of cortisol released per secretory episode. Maximum serum hormone concentrations occurred between 0706 and 1114 h. We conclude that in normal pubertal males: 1) cortisol production rates as estimated by deconvolution analysis are in agreement with other recent independent isotopic estimates, but are lower than many previous estimates; 2) the rise in serum gonadal steroid hormone levels is unassociated with alterations in the production rate or metabolic clearance of cortisol; and 3) increased secretory burst frequency, increased amplitude (maximal rate of cortisol secretion attained within each secretory event), and increased mass of cortisol released per adrenocortical secretory episode give rise to the normal diurnal rhythm of circulating cortisol.

Integrity signals

Registry

Crossref · 10.1210/jcem.76.6.8501158

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Mean cortisol production rates are influenced by age and body composition and are about 5-8 mg/m2/d, equivalent to oral replacement with 15-25 mg/d hydrocortisone or 20-35 mg cortisone acetate in adults.

    “Mean cortisol production rates are influenced by age and body composition and have been reported to be about 5-8 mg/m 2 /d (85-88), which is equivalent to an oral replacement with 15-25 mg/d (with a tendency toward the lower margin to avoid overtreatment) of hydrocortisone or 20 -35 mg of cortisone acetate in adults.”

    From Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [87]

  • During puberty, the daily requirement of hydrocortisone can vary as a consequence of endogenous sexual steroid production, so dose titration may be necessary.

    “It is worth noting that during puberty daily requirement of HC can vary as a consequence of endogenous sexual steroids production, so that dose titration may be necessary (38).”

    From X-linked adrenoleukodystrophy and primary adrenal insufficiency (2023) · cites this paper as [38]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kerrigan, J. R., Veldhuis, J. D., Leyo, S. A., Iranmanesh, A., & Rogol, A. D.
Affiliations
University of Virginia (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1993-06
Volume
76
Issue
6
Pages
1505-1510
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.76.6.8501158
OpenAlex
W2116256519
Cited by
228
References
4
Citations by year
2025: 3 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 7 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 5 · 2012: 10
FWCI
2.72
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Virginia
  • National Institutes of Health (5k04hd000634-02, 5k08hd000926-03)
  • National Center for Research Resources (RR 00847, M01RR000847)
  • NIH Clinical Center
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (RCDA 1KO4 HD 00634, HD-00926)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
cortisol production rate, cortisol clearance, sex steroids, sexual maturation, deconvolution
MeSH terms
Adolescent, Child, Circadian Rhythm, Humans, Hydrocortisone, Male, Metabolic Clearance Rate, Osmolar Concentration, Puberty, Reference Values, Time Factors, 17-Hydroxycorticosteroids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review