Temporal relationships between pulsatile cortisol secretion and electroencephalographic activity during sleep in man
Abstract
A temporal link between slow wave sleep and low or decreasing cortisol release has been previously demonstrated. This relationship was re-evaluated in 15 healthy male subjects using spectral analysis of their sleep electroencephalogram (EEG). EEG activity in the delta, theta, alpha and beta bands was cross-correlated with cortisol secretory rates at 10-min intervals. For the period of pulsatile cortisol secretion, an inverse relationship was found with the delta band with an average cross-correlation coefficient of -0.505 (P < 0.0001). Variations in cortisol secretory rates coincided with or anticipated opposite variations in delta wave activity by 10 or 20 min. A significant positive correlation was found with theta activity, but alpha and beta bands did not elicit any systematic association with cortisol profiles. These results demonstrate a temporal association between cortisol secretory pulses and delta wave activity in man, suggesting the existence of a central control common to both variables.
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During the period of pulsatile release, cortisol secretory variations are concomitant with or anticipate opposite variations in slow-wave activity (SWA) by 10-20 minutes.
“These authors showed that, during the period of pulsatile release, the cortisol secretory variations were concomitant with or anticipated opposite variations in SWA, by 10–20 minutes [47]”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [47]
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“These authors showed that, during the period of pulsatile release, the cortisol secretory variations were concomitant with or anticipated opposite variations in SWA, by 10–20 minutes [47], suggesting the existence of a common central control.”
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- Authors
- Gronfier, C., Luthringer, R., Follenius, M., Schaltenbrand, N., Macher, J. P., Muzet, A., & Brandenberger, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Centre hospitalier de Rouffach (FR)
- Corresponding author
- Gronfier, C.
- Venue
- Electroencephalography and Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 103
- Issue
- 3
- Pages
- 405-408
- ISSN
- 0013-4694 (ISSN-L)
- OpenAlex
- W1996199714
- Cited by
- 50
- References
- 15
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 5 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Electroencephalography and Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Systematics Association
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep, slow-wave sleep, delta oscillations, EEG spectral analysis, theta activity, alpha and beta bands, cross correlation function
- MeSH terms
- Adult, Brain, Electroencephalography, Humans, Hydrocortisone, Male, Sleep, Time Factors
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