Intranasal vasopressin affects pair bonding and peripheral gene expression in male Callicebus cupreus

Jarcho, M. R.; Mendoza, S. P.; Mason, W. A.; Yang, X.; Bales, K. L.

doi:10.1111/j.1601-183x.2010.00677.x

Cited by 70Neuroendocrine regulation and behaviorPrimate Behavior and EcologyOlfactory and Sensory Function Studies

Intranasal vasopressin affects pair bonding and peripheral gene expression in male Callicebus cupreus

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Jarcho, M. R., Mendoza, S. P., Mason, W. A., Yang, X., Bales, K. L.·2011·Genes, Brain and Behavior

DOI 10.1111/j.1601-183x.2010.00677.xPMC PMC3086990

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Abstract

Arginine vasopressin (AVP) is a neuropeptide hormone and neurotransmitter that has peripheral functions in water regulation, and central functions in the stress response and social bonding in male rodents. In this study, we investigated the role of AVP in partner preference behavior in a monogamous primate, the coppery titi monkey (Callicebus cupreus). Seven titi males each received three intranasal treatments: saline, low AVP (40 IU) and high AVP (80 IU) in random order, 1 week apart. They experienced a series of stimulus exposures to their female partner, a female stranger and an empty cage. Males were more likely to contact the stimulus and do so faster when either female stimulus was present. When pretreated with saline, males contacted the stranger more frequently than their partner; when pretreated with the high dosage of AVP, males contacted their partner more frequently than the stranger. We used microarray to measure peripheral changes in gene expression associated with intranasal AVP and found reduced expression of several genes coding for proinflammatory cytokines. The data presented here suggest that intranasally administered AVP has both central influences on social behavior and peripheral influences on inflammation in a nonhuman primate.

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When male titi monkeys were treated with a high dose of AVP, they increased affiliation with their long-term pairmate compared to opposite-sex strangers.
“when males were treated with a high dose of AVP, they increased affiliation with their long-term pairmate compared to opposite-sex strangers (Jarcho et al., 2011).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Jarcho et al., 2011
The effect of AVP on male titi monkey affiliation was absent in the low dose of AVP.
“This effect was absent in the low dose of AVP.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Jarcho et al., 2011

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Intranasal oxytocin does not change partner preference in female titi monkeys ( Plecturocebus cupreus ), but intranasal vasopressin decreases it
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Early Intranasal Vasopressin Administration Impairs Partner Preference in Adult Male Prairie Voles (Microtus ochrogaster)
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Central vasopressin V1a receptor activation is independently necessary for both partner preference formation and expression in socially monogamous male prairie voles
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Authors: Jarcho, M. R., Mendoza, S. P., Mason, W. A., Yang, X., & Bales, K. L.
Affiliations: University of California, Davis (US)
Corresponding author: Jarcho, M. R.
ORCID: Jarcho, M. R.
Bales, K. L.
Venue: Genes, Brain and Behavior
Publisher: Wiley
Published: 2011-01-24
Volume: 10
Issue: 3
Pages: 375-383
ISSN: 1601-183X (ISSN-L)
1601-1848
DOI: 10.1111/j.1601-183x.2010.00677.x
PMC: PMC3086990
OpenAlex: W2123374097
Cited by: 70
References: 71
Citations by year: 2025: 3 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 2 · 2014: 10 · 2013: 7 · 2012: 4
FWCI: 9.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1681 d)
Locations: Genes Brain & Behavior (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders: National Institutes of Health
National Center for Research Resources (P51RR000169, RR-00169)
California National Primate Research Center
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD053555, HD053555)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: vasopressin, intranasal administration, pair bonding, mate preferences, Callicebus cupreus, monogamy, inflammatory cytokines, inflammation, social behavior, non-human primates
MeSH terms: Administration, Intranasal, Animals, Brain Chemistry, Female, Gene Expression Regulation, Male, Pair Bond, Sexual Behavior, Animal, Sex Characteristics, Social Behavior, Vasopressins, Down-Regulation, Pitheciidae

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Intranasal vasopressin affects pair bonding and peripheral gene expression in male Callicebus cupreus

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