The DOI matches its Crossref record.
Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens.
Abstract
Studies on regional differences of adipose tissue metabolism have mainly been performed in vitro. To allow measurements of lipid uptake in vivo in man, radioactive label from [9,10-3H]oleic acid in 80 g orally administered milk fat was measured after 4 h in abdominal and femoral sc adipose tissues in 28 middle-aged, abdominally obese men. Radioactivity was measured in adipose tissue triglycerides extracted from needle biopsies. Lipoprotein lipase (LPL) activity was also measured. Uptake of label in triglycerides and LPL activity were higher (20% and 15%, respectively; P < 0.05) in the abdominal compared to the femoral adipose tissue region. The men were then randomly assigned to three groups, receiving testosterone (T), dihydrotestosterone, or placebo, for 9 months. After 2 months of treatment, the procedure of administration of label was repeated, this time using [U-14C]oleic acid as a marker. Measurements of radioactive label was then performed after 4 h and monthly up to 7 months. Supplementation with T was followed by an inhibited uptake of label in triglycerides (34%; P < 0.05), lower LPL activity (48%; P < 0.05), and a shorter t1/2 (30%; P < 0.05) in the abdominal adipose tissue region compared with the dihydrotestosterone and placebo groups. No significant effect of T on triglyceride uptake, LPL activity, or t1/2 was found in sc femoral adipose tissue. It was concluded that the turnover rate of depot triglycerides is more rapid in abdominal compared to femoral sc adipose tissue in men. Furthermore, T supplementation inhibits triglyceride uptake and LPL activity and causes a more rapid turnover of triglycerides only in the sc abdominal adipose tissue region. These results demonstrate the marked effects of T on adipose tissue metabolism in vivo and suggest that T is an important regulator of the proportion of depot fat mass in central and peripheral adipose tissue in men.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Comprising 40-50% of lean body mass in normal weight adults, skeletal muscle is the most abundant organ in the body (148).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [148]
In the citing paper
“Physiologically, skeletal muscle not only plays a significant role in maintaining posture, movement, and vital actions, skeletal muscle is also an integral regulator of whole-body metabolism as a central determinant of total daily energy expenditure and glucose homeostasis (148, 149).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [148]
Citations
Cited by
Sorted by citations
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
“These effects of testosterone on adipocyte metabolism would be expected to markedly inhibit triglyceride uptake and stimulate their mobilization seen in in vivo studies in men, suggesting that testosterone is an important regulator of the proportion of depot fat mass in central and peripheral adipose tissue in human m…”
BackgroundSex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043
“Testosterone has shown to inhibit lipoprotein lipase and uptake of triglycerides by adipose tissue (238), to increase lipolysis via -adrenergic receptors (238), and to promote increase of fat-free mass and muscle insulin sensitivity by increasing mitochondrial capacity (78).”
BackgroundDing, E. L., Song, Y., Malik, V. S., & Liu, S. (2006) · JAMA · doi:10.1001/jama.295.11.1288 · Cited by 1,354
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
Lee, M., Wu, Y., & Fried, S. K. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.001 · Cited by 861
“T administration decreases meal fat incorporation into TG in VAT (omental and retroperitoneal) preferentially (Marin et al. 1996), and into abdominal sc without affecting femoral sc uptake (Marin et al. 1995).”
Background
Metadata
- Authors
- Mårin, P., Odén, B., & Björntorp, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1995-01
- Volume
- 80
- Issue
- 1
- Pages
- 239-243
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2129627391
- Cited by
- 332
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 10 · 2012: 11
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- triglyceride uptake, adipose tissue metabolism, abdominal fat, subcutaneous adipose tissue, androgens, testosterone, dihydrotestosterone, lipoprotein lipase, triglyceride turnover, abdominal obesity
- MeSH terms
- Abdomen, Adipose Tissue, Adult, Femur, Humans, Lipoprotein Lipase, Male, Middle Aged, Skin, Dihydrotestosterone, Testosterone, Triglycerides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
