CoChat
Sign Up
Cited by 129Hormonal and reproductive studiesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Testosterone and Regional Fat Distribution

Open access
Mårin, Per·1995·Obesity Research
DOI 10.1002/j.1550-8528.1995.tb00233.x
Open this paper in CoChat — free accountOpen PDF

Abstract

The effects of testosterone treatment of abdominally obese men have been assessed by evaluating the following parameters: The metabolic activity of different adipose tissue regions in vivo (using lipid label as a tracer) and in vitro (measuring lipoprotein lipase (LPL) activity), the total and visceral adipose tissue mass, insulin sensitivity, fasting blood glucose, blood lipids, and blood pressure as well as prostate volume. Middle-aged men with abdominal obesity were treated with transdermal administration of testosterone (T), dihydrotestosterone (DHT) or placebo (P) during 9 months. The study was double-blind. Treatment with T was followed by an inhibited uptake of lipid label in adipose tissue triglycerides, a decreased LPL-activity and an increased turn-over rate of lipid label in the abdominal adipose tissue region in comparisons with the DHT and P groups. These effects on adipose tissue metabolism were not detected in the femoral adipose tissue region in any of the groups. T treatment was also followed by a specific decrease of visceral fat mass (measured by CT-scan), by increased insulin sensitivity (measured with the euglycemic glucose clamp), by a decrease in fasting blood glucose, plasma cholesterol and triglycerides as well as a decrease in diastolic blood pressure. In the DHT group an increased visceral mass was detected. No other changes in these variables were found in the DHT and P groups. There were no detectable changes in prostate volume (measured by ultra-sound), prostate specific antigen concentration, genito-urinary history or urinary flow measurements in any of the groups. It is suggested that T substitution to a selected group of men results in general metabolic and circulatory improvements. The prostate area needs further careful attention.

Integrity signals

Registry

Crossref · 10.1002/j.1550-8528.1995.tb00233.x

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Testosterone treatment improves insulin sensitivity in men at risk for type 2 diabetes mellitus.

    “Randomized controlled trials show that testosterone treatment improves insulin sensitivity in men at risk for type 2 diabetes mellitus (T2DM) [86, 87]”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [86]

  • Substantial evidence implicates testosterone and cortisol in the development of insulin resistance.

    “substantial evidence implicate testosterone and cortisol in the development of insulin resistance.”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [86]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mårin, P.
Affiliations
Sahlgrenska University Hospital (SE)
Corresponding author
Mårin, Per
Venue
Obesity Research
Publisher
Wiley
Published
1995-11
Volume
3
Issue
S4
Pages
609S-612S
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1002/j.1550-8528.1995.tb00233.x
OpenAlex
W2071063544
Cited by
129
References
22
Citations by year
2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
0.26
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6154 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
testosterone, dihydrotestosterone, abdominal obesity, visceral fat, adipose tissue metabolism, lipoprotein lipase, insulin sensitivity, serum lipids, blood pressure, prostate volume, transdermal testosterone
MeSH terms
Adipose Tissue, Body Constitution, Double-Blind Method, Humans, Male, Middle Aged, Obesity, Dihydrotestosterone, Testosterone, Triglycerides, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review