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Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens.
Abstract
Studies on regional differences of adipose tissue metabolism have mainly been performed in vitro. To allow measurements of lipid uptake in vivo in man, radioactive label from [9,10-3H]oleic acid in 80 g orally administered milk fat was measured after 4 h in abdominal and femoral sc adipose tissues in 28 middle-aged, abdominally obese men. Radioactivity was measured in adipose tissue triglycerides extracted from needle biopsies. Lipoprotein lipase (LPL) activity was also measured. Uptake of label in triglycerides and LPL activity were higher (20% and 15%, respectively; P < 0.05) in the abdominal compared to the femoral adipose tissue region. The men were then randomly assigned to three groups, receiving testosterone (T), dihydrotestosterone, or placebo, for 9 months. After 2 months of treatment, the procedure of administration of label was repeated, this time using [U-14C]oleic acid as a marker. Measurements of radioactive label was then performed after 4 h and monthly up to 7 months. Supplementation with T was followed by an inhibited uptake of label in triglycerides (34%; P < 0.05), lower LPL activity (48%; P < 0.05), and a shorter t1/2 (30%; P < 0.05) in the abdominal adipose tissue region compared with the dihydrotestosterone and placebo groups. No significant effect of T on triglyceride uptake, LPL activity, or t1/2 was found in sc femoral adipose tissue. It was concluded that the turnover rate of depot triglycerides is more rapid in abdominal compared to femoral sc adipose tissue in men. Furthermore, T supplementation inhibits triglyceride uptake and LPL activity and causes a more rapid turnover of triglycerides only in the sc abdominal adipose tissue region. These results demonstrate the marked effects of T on adipose tissue metabolism in vivo and suggest that T is an important regulator of the proportion of depot fat mass in central and peripheral adipose tissue in men.
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“Comprising 40-50% of lean body mass in normal weight adults, skeletal muscle is the most abundant organ in the body (148).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [148]
In the citing paper
“Physiologically, skeletal muscle not only plays a significant role in maintaining posture, movement, and vital actions, skeletal muscle is also an integral regulator of whole-body metabolism as a central determinant of total daily energy expenditure and glucose homeostasis (148, 149).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [148]
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Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes
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Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men
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“According to this hypothesis, increased androgen inactivation in visceral adipose tissue could have led to decreased exposition to active androgens, which have been shown to inhibit adipose tissue LPL activity and to accelerate lipid turnover in men (Mårin et al. 1995).”
Review: Testosterone and the metabolic syndrome
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“[74] and Rogers et al.”
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Metadata
- Authors
- Mårin, P., Odén, B., & Björntorp, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1995-01
- Volume
- 80
- Issue
- 1
- Pages
- 239-243
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2129627391
- Cited by
- 332
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 10 · 2012: 11
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- triglyceride uptake, adipose tissue metabolism, abdominal fat, subcutaneous adipose tissue, androgens, testosterone, dihydrotestosterone, lipoprotein lipase, triglyceride turnover, abdominal obesity
- MeSH terms
- Abdomen, Adipose Tissue, Adult, Femur, Humans, Lipoprotein Lipase, Male, Middle Aged, Skin, Dihydrotestosterone, Testosterone, Triglycerides
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