The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma.
Abstract
The in situ formation of estradiol plays an important role in the development and biological behavior of human breast cancer Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 (17 beta-HSD type 1) are two principal enzymes involved in in situ estradiol production. We evaluated the expression of aromatase and 17 beta-HSD type 1 by immunohistochemistry in 41 cases of invasive breast carcinoma (19 lobular and 22 ductal). We then examined the correlation among the expression of these enzymes, estrogen (ER) and progesterone (PR) receptor status, Ki67 labeling index of carcinoma cells, age, and the clinical stage of the patients. Marked aromatase immunoreactivity was observed in stromal cells around carcinomatous glands in 32 of 41 cases (78%), and 17 beta-HSD type 1 immunoreactivity was detected in carcinoma cells in 23 of 41 cases (56%). There was a significant correlation observed between expression of 17 beta-HSD type 1 and aromatase in invasive lobular carcinoma (P = 0.0119), but not in invasive ductal carcinoma. There was an inverse correlation between aromatase and ER status in invasive ductal carcinoma (P = 0.0213), but not in invasive lobular carcinoma. No other correlations were observed among 17 beta-HSD type 1, aromatase, PR, ER, clinical stage, age, and Ki67 labeling indexes. Aromatase and 17 beta-HSD are not always expressed simultaneously in human breast carcinoma, but their simultaneous expression is more frequent in invasive lobular carcinoma than invasive ductal carcinoma. Consequently, different mechanisms may be involved in the regulation of expression of these two enzymes in human breast carcinoma.
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“Nevertheless, 17HSD1 is probably critical for ovulation and may be important in the pathogenesis and progression of estrogen-dependent breast cancers (512).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [512]
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Metadata
- Authors
- Sasano, H., Frost, A. R., Saitoh, R., Harada, N., Poutanen, M., Vihko, R., Bulun, S. E., Silverberg, S. G., & Nagura, H.
- Affiliations
- Tohoku University (JP)
- George Washington University (US)
- Fujita Health University (JP)
- The University of Texas at Dallas (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1996-11
- Volume
- 81
- Issue
- 11
- Pages
- 4042-4046
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1993913378
- Cited by
- 167
- References
- 17
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- aromatase, breast cancer, invasive lobular carcinoma, invasive ductal carcinoma, estrogen receptor, progesterone receptor, Ki-67 proliferation index, tumor stroma
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aromatase, Breast Neoplasms, Estradiol, Female, Humans, Immunohistochemistry, Middle Aged, Receptors, Estrogen, Receptors, Progesterone, 17-Hydroxysteroid Dehydrogenases, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Ki-67 Antigen
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