Sex steroid-producing enzymes in human breast cancer

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,865 · see citing works

Biochemical and Biophysical Research Communications

Rc, A. N., On Filamentous Bacteriophage, M., Hoffmann, S., & Willbold, D. (1960) · Nature · doi:10.1038/186124d0 · Cited by 6,690 · see citing works

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM

Hoskins, R. G. (1953) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-13-4-473 · Cited by 3,806 · see citing works

Molecular and cellular endocrinology

(1995) · Journal of Endocrinology · doi:10.1677/joe.0.147so19 · Cited by 1,986 · see citing works

A Randomized Trial of Letrozole in Postmenopausal Women after Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer

Goss, P. E., Ingle, J. N., Martino, S., Robert, N. J., Muss, H. B., Piccart, M. J., Castiglione, M., Tu, D., Shepherd, L. E., Pritchard, K. I., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa032312 · Cited by 1,795 · see citing works

A Randomized Trial of Exemestane after Two to Three Years of Tamoxifen Therapy in Postmenopausal Women with Primary Breast Cancer

Coombes, R. C., Hall, E., Gibson, L. J., Paridaens, R., Jassem, J., Delozier, T., Jones, S. E., Alvarez, I., Bertelli, G., Ortmann, O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040331 · Cited by 1,759 · see citing works

The Journal of Steroid Biochemistry and Molecular Biology

(2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(11)00143-9 · Cited by 1,233 · see citing works

Steroid 5α-reductase: two genes/two enzymes

Russell, D. W., & Wilson, J. D. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000325 · Cited by 1,105 · see citing works

Letrozole Is More Effective Neoadjuvant Endocrine Therapy Than Tamoxifen for ErbB-1– and/or ErbB-2–Positive, Estrogen Receptor–Positive Primary Breast Cancer: Evidence From a Phase III Randomized Trial

Ellis, M. J., Coop, A., Singh, B., Mauriac, L., Llombert-Cussac, A., Jänicke, F., Miller, W. R., Evans, D. B., Dugan, M. H., Brady, C., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.18.3808 · Cited by 1,059 · see citing works

Breast Cancer Research and Treatment

Alexander, M. C. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006151427889 · Cited by 1,017 · see citing works

Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype

Frasor, J. M., Danes, J. M., Komm, B. S., Chang, K. C. N., Lyttle, C. R., & Katzenellenbogen, B. S. (2003) · Endocrinology · doi:10.1210/en.2003-0567 · Cited by 875 · see citing works

Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer.

Osborne, C., Bardou, V., Hopp, T. A., Chamness, G., Hilsenbeck, S., Fuqua, S., Wong, J., Allred, D., Clark, G., & Schiff, R. (2003) · Journal of the National Cancer Institute · doi:10.1093/jnci/95.5.353 · Cited by 831 · see citing works

Steroidogenic factor 1: a key determinant of endocrine development and function

Parker, K. L., & Schimmer, B. P. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0301 · Cited by 764 · see citing works

Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3

Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570 · see citing works

Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone

Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · cited 10× · see citing works

Steroid sulfatase: molecular biology, regulation, and inhibition

Reed, M. J., Purohit, A., Woo, L. W. L., Newman, S. P., & Potter, B. V. L. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0003 · Cited by 524 · see citing works

Minireview: Aromatase and the Regulation of Estrogen Biosynthesis--Some New Perspectives

Simpson, E. R., & Davis, S. R. (2001) · Endocrinology · doi:10.1210/endo.142.11.8547 · Cited by 501 · see citing works

Aromatase Inhibitors in the Treatment of Breast Cancer

Brueggemeier, R. W., Hackett, J. C., & Díaz‐Cruz, E. S. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0015 · Cited by 489 · see citing works

Is Estradiol a Genotoxic Mutagenic Carcinogen?1

Liehr, J. G. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0386 · Cited by 486 · see citing works

Journal of Histochemistry and Cytochemistry

(1953) · Nature · doi:10.1038/172232b0 · Cited by 471 · see citing works

Crosstalk between Estrogen Receptor and Growth Factor Receptor Pathways as a Cause for Endocrine Therapy Resistance in Breast Cancer

Osborne, C. K., Shou, J., Massarweh, S. A., & Schiff, R. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.865s.11.2 · Cited by 459 · see citing works

Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

Wu, L., Einstein, M., Geissler, W. M., Chan, H. K., Elliston, K. O., & Andersson, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31480-7 · Cited by 437 · see citing works

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene

Zhao, Y. D., Agarwal, V. R., Mendelson, C. R., & Simpson, E. R. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940410 · Cited by 434 · see citing works

Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients

Pasqualini, J. R., Chetrite, G. S., Blacker, C., Feinstein, M. C., Delalonde, L., Talbi, M., & Maloche, C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636351 · Cited by 433 · see citing works

In Situ Estrogen Production via the Estrone Sulfatase Pathway in Breast Tumors: Relative Importance versus the Aromatase Pathway*

Santner, S. J., Feil, P. D., & Santen, R. J. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-1-29 · Cited by 407 · see citing works

Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ ⁵ -Δ ⁴ -lsomerase in Human Adrenals and Gonads

Rhéaume, E., Lachance, Y., Zhao, H.-F., Breton, N., Dumont, M., Launoit, Y. D., Trudel, C., Luu-The, V., Simard, J., & Labrie, F. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-8-1147 · Cited by 362 · see citing works

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

Bulun, S. E., Price, T. M., Aitken, R. J., Mahendroo, M., & Simpson, E. R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8117355 · Cited by 334 · see citing works

Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA

Peltoketo, H., Isomaa, V., Mäentausta, O., & Vihko, R. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80548-9 · Cited by 294 · see citing works

The importance of local synthesis of estrogen within the breast

Miller, W. R., & O'Neill, J. (1987) · Steroids · doi:10.1016/0039-128x(87)90037-7 · Cited by 280 · see citing works

Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues

Chetrite, G. S., Cortés-Prieto, J., Philippe, J.-C., Wright, F., & Pasqualini, J. R. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00040-6 · Cited by 278 · see citing works

Characterization of cDNAs for Human Estradiol 17β-Dehydrogenase and Assignment of the Gene to Chromosome 17: Evidence of two mRNA Species with Distinct 5′-Termini in Human Placenta

The, V. L., Labrie, C., Zhao, H. F., Couët, J., Lachance, Y., Simard, J., Leblanc, G., Côté, J., Bérubé, D., Gagné, R., et al. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1301 · Cited by 274 · see citing works

The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

Purohit, A., Newman, S. P., & Reed, M. (2002) · Breast Cancer Research · doi:10.1186/bcr425 · Cited by 256 · see citing works

Characteristics of a Highly Labile Human Type 5 17β-Hydroxysteroid Dehydrogenase1

Dufort, I., Rheault, P., Huang, X.-F., Soucy, P., & Luu-The, V. (1999) · Endocrinology · doi:10.1210/endo.140.2.6531 · Cited by 255 · see citing works

Human CYP1B1 Is Regulated by Estradiol via Estrogen Receptor

Tsuchiya, Y., Nakajima, M., Kyo, S., Kanaya, T., Inoue, M., & Yokoi, T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0166 · Cited by 249 · see citing works

The role of COX-2 inhibition in breast cancer treatment and prevention

Arun, B., & Goss, P. E. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.03.042 · Cited by 236 · see citing works

Liver Receptor Homologue-1 (LRH-1) Regulates Expression of Aromatase in Preadipocytes

Clyne, C. D., Speed, C. J., Zhou, J., & Simpson, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201117200 · Cited by 233 · see citing works

Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies

Sasano, H., & Harada, N. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0342 · Cited by 223 · see citing works

Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase

Falany, C. N., Krasnykh, V., & Falany, J. L. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00015-r · Cited by 220 · see citing works

Estrogen-Related Receptor α in Human Breast Carcinoma as a Potent Prognostic Factor

Suzuki, T., Miki, Y., Moriya, T., Shimada, N., Ishida, T., Hirakawa, H., Ohuchi, N., & Sasano, H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0250 · Cited by 219 · see citing works

New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarrays.

Kauraniemi, P., Barlund, M. T., Monni, O. M., & Kallioniemi, A. H. (2001) · PubMed · Cited by 214 · see citing works

Testosterone Effects on the Breast: Implications for Testosterone Therapy for Women

Somboonporn, W., & Davis, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0016 · Cited by 214 · see citing works

Cytochrome P450 biosensors—a review

Bistolas, N., Wollenberger, U., Jung, C., & Scheller, F. W. (2005) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.11.023 · Cited by 211 · see citing works

Aromatase activity and interleukin-6 production by normal and malignant breast tissues

Purohit, A., Ghilchik, M. W., Duncan, L., Wang, D. Y., Singh, A., Walker, M. M., & Reed, M. J. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.10.7559896 · Cited by 201 · see citing works

Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer

Pasqualini, J. R., & Chetrite, G. S. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.02.007 · Cited by 194 · see citing works

The selective estrogen enzyme modulators in breast cancer: a review

Pasqualini, J. R. (2004) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2004.03.001 · Cited by 192 · see citing works

Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers

Lü, Q., Nakmura, J., Savinov, A. Y., Yue, W., Weisz, J., Dabbs, D. J., Wolz, G., & Brodie, A. (1996) · Endocrinology · doi:10.1210/endo.137.7.8770932 · Cited by 189 · see citing works

Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma.

Suzuki, T., Nakata, T., Miki, Y., Kaneko, C., Moriya, T., Ishida, T., Akinaga, S., Hirakawa, H., Kimura, M., & Sasano, H. (2003) · PubMed · Cited by 185 · see citing works

Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function

Parker, K. L. (1997) · Endocrine Reviews · doi:10.1210/er.18.3.361 · Cited by 185 · see citing works

Expression of cytochromes P450 in human breast tissue and tumors.

Huang, Z., Fasco, M. J., Figge, H. L., Keyomarsi, K., & Kaminsky, L. S. (1996) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07451-3 · Cited by 184 · see citing works

Synergistic Activation of the Human Type II 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Promoter by the Transcription Factor Steroidogenic Factor-1/Adrenal 4-binding Protein and Phorbol Ester

Leers‐Sucheta, S., Morohashi, K.-I., Mason, J. I., & Melner, M. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7960 · Cited by 179 · see citing works

Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders

Sasano, H., Nagura, H., Harada, N., Goukon, Y., & Kimura, M. (1994) · Human Pathology · doi:10.1016/0046-8177(94)90127-9 · Cited by 173 · see citing works

Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma.

Sasano, H., Frost, A. R., Saitoh, R., Harada, N., Poutanen, M., Vihko, R., Bulun, S. E., Silverberg, S. G., & Nagura, H. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923858 · Cited by 167 · see citing works

Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines.

Falany, J. L., & Falany, C. N. (1996) · PubMed · Cited by 165 · see citing works

Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation.

Esteban, J. M., Warsi, Z., Haniu, M., Hall, P. F., Shively, J. E., & Chen, S. (1992) · PubMed Central · Cited by 163 · see citing works

Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors

Isola, J. J. (1993) · The Journal of Pathology · doi:10.1002/path.1711700106 · Cited by 157 · see citing works

Cyclooxygenase Inhibitors Suppress Aromatase Expression and Activity in Breast Cancer Cells

Díaz‐Cruz, E. S., Shapiro, C. L., & Brueggemeier, R. W. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2029 · Cited by 156 · see citing works

Stromal spindle cells contain aromatase in human breast tumors

Santen, R. J., Martel, J., Hoagland, M. S., Naftolin, F. N., Roa, L., Harada, N., Hafer, L. J., Zaino, R. J., & Santner, S. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045987 · Cited by 153 · see citing works

Aromatase and COX-2 expression in human breast cancers

Brodie, A. M., Lü, Q., Long, B. J., Fulton, A. M., Chen, T., Macpherson, N. A., DeJong, P. C., Blankenstein, M. A., Nortier, J. W. R., Slee, P. H. T. J., et al. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00131-5 · Cited by 150 · see citing works

Involvement of up-regulation of 17?-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers

Miyoshi, Y., Ando, A., Shiba, E., Taguchi, T., Tamaki, Y., & Noguchi, S. (2001) · International Journal of Cancer · doi:10.1002/ijc.1525 · Cited by 148 · see citing works

Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer.

Utsumi, T., Yoshimura, N., Takeuchi, S., Ando, J., MARUTA, M., Maeda, K., & Harada, N. (1999) · PubMed · Cited by 144 · see citing works

Aromatase activity in breast tissue

Miller, W. R. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90026-2 · Cited by 143 · see citing works

Human Liver Estrogen Sulfotransferase: Identification by cDNA Cloning and Expression

Aksoy, I. A., Wood, T. C., & Weinshilboum, R. M. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1637 · Cited by 139 · see citing works

Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes

Sirianni, R., Seely, J. B., Attia, G., Stocco, D., Carr, B., Pezzi, V., & Rainey, W. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.174r013 · Cited by 137 · see citing works

17 β -Hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters

Suzuki, T., Moriya, T., Ariga, N., Kaneko, C., Kanazawa, M., & Sasano, H. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.0956 · Cited by 130 · see citing works

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma

Lewis, M. J., Wiebe, J. P., & Heathcote, J. G. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-27 · Cited by 127 · see citing works

Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism

Jin, Y., & Penning, T. M. (2001) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2001.0120 · Cited by 125 · see citing works

The Pregnane X Receptor Regulates Gene Expression in a Ligand- and Promoter- Selective Fashion

Masuyama, H., Suwaki, N., Tateishi, Y., Nakatsukasa, H., Segawa, T., & Hiramatsu, Y. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0434 · Cited by 123 · see citing works

Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor.

Yang, C., Zhou, D., & Chen, S. (1998) · PubMed · Cited by 121 · see citing works

Immunohistochemical Localization of Cytochrome P450 CYP1B1 in Breast Cancer with Monoclonal Antibodies Specific for CYP1B1

McFadyen, M. C. E., Breeman, S., Payne, S., Stirk, C. M., Miller, I. D., Melvin, W. T., & Murray, G. I. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904701111 · Cited by 120 · see citing works

Selective Loss of AKR1C1 and AKR1C2 in Breast Cancer and Their Potential Effect on Progesterone Signaling

Ji, Q., Aoyama, C., Nien, Y.-D., Liu, P. I., Chen, P. K., Chang, L., Stanczyk, F. Z., & Stolz, A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1608 · Cited by 119 · see citing works

Interactions between Prostaglandin E2, Liver Receptor Homologue-1, and Aromatase in Breast Cancer

Zhou, J., Suzuki, T., Kovacic, A., Saito, R., Miki, Y., Ishida, T., Moriya, T., Simpson, E. R., Sasano, H., & Clyne, C. D. (2005) · Cancer Research · doi:10.1158/0008-5472.657.65.2 · Cited by 118 · see citing works

Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism

Kristensen, V. N., & Børresen‐Dale, A. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00018-1 · Cited by 116 · see citing works

The 4-pregnene and 5alpha-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion.

Wiebe, J. P., Muzia, D., Hu, J. J., Szwajcer, D., Hill, S. A., & Seachrist, J. L. (2000) · PubMed · Cited by 114 · see citing works

Presence of alternatively spliced transcripts of aromatase gene in human breast cancer

Utsumi, T., Harada, N., MARUTA, M., & Takagi, Y. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.6.8964875 · Cited by 113 · see citing works

Relationship between tumour aromatase activity, tumour characteristics and response to therapy

Miller, W. R., Anderson, T. J., & Jack, W. J. L. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90465-w · Cited by 108 · see citing works

Intratumoral aromatase as a prognostic factor in human breast carcinoma.

Mc, S., Mg, R., Dowsett, M., Gusterson, B. A., McKinna, J. A., Fryatt, I., & Coombes, R. C. (1989) · PubMed · Cited by 107 · see citing works

The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

İşcan, M., Klaavuniemi, T., Çoban, T., Kapucuoğlu, N., Pelkonen, O., & Raunio, H. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1012526406741 · Cited by 106 · see citing works

Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.

Zhou, J. N., Gürateş, B., Yang, S., Sebastian, S., & Bulun, S. E. (2001) · PubMed · Cited by 106 · see citing works

Type 5 17β-hydroxysteroid dehydrogenase: its role in the formation of androgens in women

Luu-The, V., Dufort, I., Pelletier, G., & Labrie, F. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00425-1 · Cited by 105 · see citing works

Abnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence.

Gunnarsson, C., Olsson, B., & Stål, O. (2001) · PubMed · Cited by 105 · see citing works

Expression and Potential Roles of Pregnane X Receptor in Endometrial Cancer

Masuyama, H., Hiramatsu, Y., Kodama, J.-I., & Kudo, T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030203 · Cited by 105 · see citing works

Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies

Sasano, H. (1998) · Endocrine Reviews · doi:10.1210/er.19.5.593 · Cited by 104 · see citing works

Testosterone, dihydrotestosterone and oestradiol levels in postmenopausal breast cancer tissues

Recchione, C., Venturelli, E., Manzari, A., Cavalleri, A., Martinetti, A., & Secreto, G. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00017-t · Cited by 101 · see citing works

Testosterone and 5α-dihydrotestosterone inhibitin vitrogrowth of human breast cancer cell lines

Ortmann, J., Prifti, S., Bohlmann, M. K., Rehberger-Schneider, S., Strowitzki, T., & Rabe, T. (2002) · Gynecological Endocrinology · doi:10.1080/gye.16.2.113.120 · Cited by 100 · see citing works

Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma

Tseng, L., Mazella, J., Lee, L. Y., & Stone, M. L. (1983) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(83)91116-0 · Cited by 99 · see citing works

High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer.

Miyoshi, Y., Ando, A., Hasegawa, S., Ishitobi, M., Taguchi, T., Tamaki, Y., & Noguchi, S. (2003) · PubMed · Cited by 99 · see citing works

Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics

Adjei, A. A., Thomae, B. A., Prondzinski, J. L., Eckloff, B. W., Wieben, E. D., & Weinshilboum, R. M. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705369 · Cited by 98 · see citing works

Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha.

Kinoshita, Y., & Chen, S. (2003) · PubMed · Cited by 97 · see citing works

Short-term primary culture of epithelial cells derived from human breast tumours

Speirs, V., Green, A. R., Walton, D., Kerin, M. J., Fox, J. N., Carleton, P. J., Desai, S. B., & Atkin, S. L. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.702 · Cited by 95 · see citing works

Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)

Penning, T. M., Burczynski, M. E., Jez, J. M., Lin, H.-K., Ma, H., Moore, M., Ratnam, K., & Palackal, N. T. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00426-3 · Cited by 95 · see citing works

Regulation of MCF-7 Breast Cancer Cell Growth by β-estradiol Sulfation

Falany, J. L., Macrina, N., & Falany, C. N. (2002) · Breast Cancer Research and Treatment · doi:10.1023/a:1016147004188 · Cited by 92 · see citing works

Immunocytochemical Localization of Type 5 17 β-Hydroxysteroid Dehydrogenase in Human Reproductive Tissues

Pelletier, G., Luu-The, V., Tětu, B., & Labrie, F. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904700602 · Cited by 88 · see citing works

A concerted, rational design of type 1 17β‐hydroxysteroid dehydrogenase inhibitors: estradiol‐adenosine hybrids with high affinity

Qiu, W., Campbell, R. L., Gangloff, A., Dupuis, P., Boivin, R. P., Tremblay, M. R., Poirier, D., & Lin, S. (2002) · The FASEB Journal · doi:10.1096/fj.02-0026fje · Cited by 85 · see citing works

Cloning and Characterization of a Novel Endothelial Promoter of the Human CYP19 (Aromatase P450) Gene that Is Up-Regulated in Breast Cancer Tissue

Sebastian, S., Takayama, K., Shozu, M., & Bulun, S. E. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0123 · Cited by 85 · see citing works

The regulation of aromatase activity in breast fibroblasts: the role of interleukin-6 and prostaglandin E2.

Singh, A., Purohit, A., Ghilchik, M., & Reed, M. J. (1999) · Endocrine-Related Cancer · doi:10.1677/erc.0.0060139 · Cited by 84 · see citing works

Amplification of HSD17B1 and ERBB2 in primary breast cancer

Gunnarsson, C., Waltersson, M. A., Kirschner, K., Olsson, B., Nordenskjöld, B. A., Rutqvist, L. E., Skoog, L. K., & Stål, O. (2003) · Oncogene · doi:10.1038/sj.onc.1206078 · Cited by 83 · see citing works

The use of gonadotrophin-releasing hormone (GnRH) agonists in early and advanced breast cancer in pre- and perimenopausal women

Robertson, J. F. R., & Blamey, R. W. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00810-9 · Cited by 83 · see citing works

Characterization of Cytochrome P450 Enzymes in Human Breast Tissue from Reduction Mammaplasties1

Hellmold, H., Rylander‐Rudqvist, T., Magnusson, M., Reihnér, E., Warner, M. N., & Gustafsson, J.-Α. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4647 · Cited by 82 · see citing works

Prognostic value of breast cancer aromatase

Lipton, A., Santen, R. J., Santner, S. J., Harvey, H. A., Sanders, S. I., & Matthews, Y. L. (1992) · Cancer · doi:10.1002/1097-0142(19921001)70:7 · Cited by 80 · see citing works

Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line

Sonne‐Hansen, K., & Lykkesfeldt, A. E. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.11.005 · Cited by 78 · see citing works

Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydrotestosterone; a role for p21(Cip1/Waf1)

Greeve, M., Allan, R. K., Harvey, J. A., & Bentel, J. M. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0320793 · Cited by 78 · see citing works

Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status

Angus, W. G. R. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.947 · Cited by 78 · see citing works

17 beta-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin.

POUTANEN, M. H., Moncharmont, B., & Vihko, R. (1992) · PubMed · Cited by 77 · see citing works

Induction of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Type 1 Gene Transcription in Human Breast Cancer Cell Lines and in Normal Mammary Epithelial Cells by Interleukin-4 and Interleukin-13

Gingras, S., Moriggl, R., Groner, B., & Simard, J. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.1.0221 · Cited by 76 · see citing works

Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer.

Surmacz, E., & Bartucci, M. (2004) · PubMed · Cited by 72 · see citing works

5α-Reductases in Human Breast Carcinoma: Possible Modulator ofin SituAndrogenic Actions1

Suzuki, T., Darnel, A. D., Akahira, J., Ariga, N., Ogawa, S. A., Kaneko, C., Takeyama, J., Moriya, T., & Sasano, H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7444 · Cited by 72 · see citing works

Cytochrome p450 and glutathione transferase expression in human breast cancer.

El-Rayes, B. F., Ali, S. S., Heilbrun, L. K., Lababidi, S., Bouwman, D. L., Visscher, D., & Philip, P. A. (2003) · PubMed · Cited by 69 · see citing works

Expression of Estrogen Sulfotransferase in MCF-7 Cells by cDNA Transfection Suppresses the Estrogen Response: Potential Role of the Enzyme in Regulating Estrogen-Dependent Growth of Breast Epithelial Cells

Qian, Y., Deng, C., & Song, W. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37617-7 · Cited by 68 · see citing works

A Potential Role for the Estrogen-metabolizing Cytochrome P450 Enzymes in Human Breast Carcinogenesis

Modugno, F., Knoll, C. A., Kanbour‐Shakir, A., & Romkes, M. (2003) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000004376.21491.44 · Cited by 65 · see citing works

Correlation of Breast Tumour Aromatase Activity and Response to Aromatase Inhibition with Aminoglutethimide

Bezwoda, W. R., Mansoor, N., & Dansey, R. (2009) · Oncology · doi:10.1159/000226509 · Cited by 65 · see citing works

17β‐hydroxysteroid dehydrogenases in normal human mammary epithelial cells and breast tissue

Miettinen, M., Mustonen, M. V. J., POUTANEN, M. H., ISOMAA, V. V., Wickman, M., Söderqvist, G., Vihko, R., & Vihko, P. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006217400137 · Cited by 63 · see citing works

Regulation of steroid sulphatase expression and activity in breast cancer

Newman, S. P., Purohit, A., Ghilchik, M. W., Potter, B. V. L., & Reed, M. J. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00177-1 · Cited by 62 · see citing works

Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma

Evans, T., Rowlands, M. G., Law, M. G., & Coombes, R. C. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.101 · Cited by 60 · see citing works

Regulation of 3 beta-hydroxysteroid dehydrogenase and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels by cyclic adenosine 3',5'-monophosphate and phorbol myristate acetate in human choriocarcinoma cells.

Tremblay, Y., & Beaudoin, C. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.3.8387158 · Cited by 59 · see citing works

Tumor-Stromal Interaction through the Estrogen-Signaling Pathway in Human Breast Cancer

Yamaguchi, Y., Takei, H., Suemasu, K., Kobayashi, Y., Kurosumi, M., Harada, N., & Hayashi, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3236 · Cited by 59 · see citing works

Regulation of CYP3A genes in the human respiratory tract

Raunio, H., Hakkola, J., & Pelkonen, O. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2003.12.007 · Cited by 55 · see citing works

Aromatase regulation and breast cancer

Reed, M. J., & Purohit, A. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01276.x · Cited by 53 · see citing works

Steroid 5-alpha Reductase: Two Genes/Two Enzymes

Russell, D. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.63.1.25 · Cited by 53 · see citing works

A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma.

Adams, J. B., Pewnim, T., Chandra, D. P., Archibald, L., & Foo, M. S. (1979) · PubMed · Cited by 52 · see citing works

Aromatase activity and estradiol in human breast cancer: its relationship to estradiol and epidermal growth factor receptors and to tumor-node-metastasis staging.

Bolufer, P., Ricart, E., Lluch, A. M., Vazquez, C., Rodrı́guez, A., Ruíz, A., Llopis, F., García-Conde, J., & Romero, R. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.3.438 · Cited by 52 · see citing works

Characterization of Cytochrome P450 Enzymes in Human Breast Tissue from Reduction Mammaplasties

Hellmold, H. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.886 · Cited by 50 · see citing works

Enzymes as modulators in malignant transformation

Vihko, P., Herrala, A. M., Härkönen, P. K., ISOMAA, V. V., Kaija, H., Kurkela, R., Li, Y., Patrikainen, L., Pulkka, A. E., Soronen, P., et al. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.01.002 · Cited by 49 · see citing works

SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells

Spink, B. C. (2000) · Carcinogenesis · doi:10.1093/carcin/21.11.1947 · Cited by 49 · see citing works

Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer

Yoshimura, N., Harada, N., Bukholm, I., Kåresen, R., Børresen‐Dale, A., & Kristensen, V. N. (2003) · Breast Cancer Research · doi:10.1186/bcr746 · Cited by 45 · see citing works

Validation of new aromatase monoclonal antibodies for immunohistochemistry: progress report

Sasano, H., Edwards, D. P., Anderson, T. J., Silverberg, S. G., Evans, D. B., Santen, R. J., Ramage, P., Simpson, E. R., Bhatnagar, A. S., & Miller, W. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00363-7 · Cited by 45 · see citing works

Regulation of estradiol 17 beta-hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells

Reed, M. J., Rea, D., Duncan, L., & Parker, M. G. (1994) · Endocrinology · doi:10.1210/endo.135.1.8013376 · Cited by 44 · see citing works

Expression of CYP3A4 in human breast tumour and non-tumour tissues

Kapucuoğlu, N., Çoban, T., Raunio, H., Pelkonen, O., Edwards, R. J., Boobis, A. R., & İşcan, M. (2003) · Cancer Letters · doi:10.1016/j.canlet.2003.08.015 · Cited by 40 · see citing works

Crucial role of cytokines in sex steroid formation in normal and tumoral tissues

Simard, J., & Gingras, S. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00387-7 · Cited by 40 · see citing works

The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics

Wiebe, J. P., Lewis, M. J., Cialacu, V., Pawlak, K. J., & Zhang, G. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.003 · Cited by 39 · see citing works

Effect of the progestagen Promegestone (R-5020) on mRNA of the oestrone sulphatase in the MCF-7 human mammary cancer cells.

Pasqualini, J. R., Maloche, C., Maroni, M., & Chetrite, G. S. (1994) · PubMed · Cited by 39 · see citing works

Comparison of biochemical aromatase activity with aromatase immunhistochemistry in human breast carcinomas

Shenton, K., Dowsett, M., Lü, Q., Brodie, A. M., Sasano, H., Sacks, N. P. M., & Rowlands, M. G. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006033813899 · Cited by 36 · see citing works

An integrated view of aromatase and its inhibition

Miller, W. R., Anderson, T. J., Evans, D. B., Krause, A., Hampton, G. M., & Dixon, J. M. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00352-2 · Cited by 36 · see citing works

3β-Hydroxysteroid Dehydrogenase Activity in Glandular and Extraglandular Human Fetal Tissues*

Milewich, L., Shaw, C. E., Doody, K. M., Rainey, W. E., Mason, J. I., & Carr, B. R. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1134 · Cited by 36 · see citing works

Importance of local aromatase activity in hormone-dependent breast cancer: a review

de Jong, P. C., Blankenstein, M. A., van de Ven, J., Nortier, J. W. R., Blijham, G. H., & Thijssen, J. H. H. (2001) · The Breast · doi:10.1054/brst.2000.0209 · Cited by 35 · see citing works

3β-Hydroxysteroid Dehydrogenase/Δ5→4-Isomerase Activity Associated with the Human 17β-Hydroxysteroid Dehydrogenase Type 2 Isoform1

SUZUKI, T. A., Sasano, H., Andersson, S., & Mason, J. I. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6918 · Cited by 32 · see citing works

17 beta-Hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human breast.

Ariga, N., Moriya, T., Suzuki, T., Kimura, M., Ohuchi, N., Satomi, S., & Sasano, H. (2000) · PubMed · Cited by 32 · see citing works

Human estrogen sulfotransferase (hEST1) activities and its mRNA in various breast cancer cell lines. Effect of the progestin, promegestone (R-5020)

Chetrite, G. S., Nestour, E. L., & Pasqualini, J. R. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00063-6 · Cited by 31 · see citing works

Localization of estrone sulfatase in human breast carcinomas

Saeki, T., Takashima, S., Sasaki, H., Hanai, N., & Salomon, D. S. (1999) · Breast Cancer · doi:10.1007/bf02966449 · Cited by 30 · see citing works

Role of the Cyclin-Dependent Kinase Inhibitor p27Kip1 in Androgen-Induced Inhibition of CAMA-1 Breast Cancer Cell Proliferation

Lapointe, J., & Labrie, C. (2001) · Endocrinology · doi:10.1210/endo.142.10.8417 · Cited by 30 · see citing works

Differential effects of progestins on breast tissue enzymes

Pasqualini, J. R. (2003) · Maturitas · doi:10.1016/j.maturitas.2003.09.018 · Cited by 28 · see citing works

Retinoid Receptors in Human Breast Carcinoma: Possible Modulators of in Situ Estrogen Metabolism

Suzuki, T., Moriya, T., Sugawara, A., Ariga, N., Takabayashi, H., & Sasano, H. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1006433929792 · Cited by 28 · see citing works

Current Status of Aromatase Inhibitors in the Management of Breast Cancer and Critique of the NCIC MA-17 Trial

Baum, M. S. (2004) · Cancer Control · doi:10.1177/107327480401100402 · Cited by 28 · see citing works

Multiple Signaling Pathways Mediate Interleukin-4-Induced 3 -Hydroxysteroid Dehydrogenase/ 5- 4 Isomerase Type 1 Gene Expression in Human Breast Cancer Cells

Gingras, S., Côté, S., & Simard, J. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.2.0416 · Cited by 24 · see citing works

Regulation of 3 beta-hydroxysteroid dehydrogenase and 17 beta- hydroxysteroid dehydrogenase messenger ribonucleic acid levels by cyclic adenosine 3',5'-monophosphate and phorbol myristate acetate in human choriocarcinoma cells

Tremblay, Y. (1993) · Molecular Endocrinology · doi:10.1210/me.7.3.355 · Cited by 22 · see citing works

Steroid-Metabolizing Enzymes in Human Breast Cancer Cells. II. 5α-Reductase, 3α-Hydroxysteroid Oxidoreductase, and 17β-Hydroxysteroid Oxidor educt ase*

MacIndoe, J. H., & Gayle, R. (1981) · Endocrinology · doi:10.1210/endo-108-4-1407 · Cited by 20 · see citing works

Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer

Tsunehiro, O. (2005) · Frontiers in bioscience · doi:10.2741/1608 · Cited by 19 · see citing works

Immunohistochemical analysis of estrone sulfatase and aromatase in human breast cancer tissues

Yamamoto, Y., Yamashita, J.-I., Toi, M., Muta, M., Nagai, S. E., Hanai, N., Furuya, A., Osawa, Y., Saji, S., & Ogawa, M. (2003) · Oncology Reports · doi:10.3892/or.10.4.791 · Cited by 18 · see citing works

Expression of 3β-hydroxysteroid dehydrogenase-5,4-en isomerase activity by infiltrating ductal human breast carcinoma in vitro

Gunasegaram, R., Peh, K. L., Loganath, A., & Ratnam, S. S. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006009031839 · Cited by 18 · see citing works

Erratum: A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription (Journal of Clinical Endocrinology and Metabolism (1993) 77 (1622-1628))

Bulun, S. E., Price, T. M., Aitken, R. J., Mahendroo, M., & Simpson, E. R. (1994) · The Journal of Clinical Endocrinology & Metabolism · Cited by 14 · see citing works

Progesterone Metabolism in Human Leukemic Monoblast U937 Cells.

Suzuki, T., Murry, B. A., Darnel, A. D., & Sasano, H. (2002) · Endocrine Journal · doi:10.1507/endocrj.49.539 · Cited by 12 · see citing works

Selecting adjuvant endocrine therapy for breast cancer.

Eneman, J. D., Wood, M. E., & Muss, H. B. (2004) · PubMed · Cited by 9 · see citing works

Correlation of breast tumour aromatase activity and response to aromatase inhibition with aminoglutethimide

Bezwoda, W. R., Mansoor, N., & Dansey, R. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)91520-2 · Cited by 6 · see citing works

Immunolocalisation of Cytochrome P‐450 3A Enzymes in Human Breast Carcinoma: Relationship with Tumour Differentiation and Steroid Receptors

Galant, C., Gala, J., Berge, V. V. D., Berlière, M., Haumont, E., & Horsmans, Y. (2001) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2001.d01-95.x · Cited by 5 · see citing works

Steroid sulfatase inhibitors

Nußbaumer, P., & Billich, A. (2003) · Expert Opinion on Therapeutic Patents · doi:10.1517/eotp.13.5.605.23032 · Cited by 5 · see citing works

Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression

Vona-Davis, L., & Rose, D. P. (2007) · Endocrine-Related Cancer · doi:10.1677/erc-06-0068 · Cited by 496 · see citing works

Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression

Bhardwaj, P., Au, C. C., Benito-Martin, A., Ladumor, H., Oshchepkova, S., Moges, R., & Brown, K. A. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.002 · Cited by 233 · see citing works

Intracrine androgen biosynthesis, metabolism and action revisited

Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works

Aromatase expression and regulation in breast and endometrial cancer

Zhao, H., Zhou, L., Shangguan, A. J., & Bulun, S. E. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0310 · Cited by 217 · see citing works

Intratumoral Estrogens and Estrogen Receptors in Human Non–Small Cell Lung Carcinoma

Niikawa, H., Suzuki, T., Miki, Y., Suzuki, S., Nagasaki, S., Akahira, J., Honma, S., Evans, D. B., Hayashi, S., Kondo, T., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1950 · Cited by 195 · see citing works

Phytoestrogens and breast cancer –promoters or protectors?

Rice, S., & Whitehead, S. A. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01159 · Cited by 192 · see citing works

Letrozole is Superior to Anastrozole in Suppressing Breast Cancer Tissue and Plasma Estrogen Levels

Geisler, J., Helle, H., Ekse, D., Duong, N. K., Evans, D. B., Nordbø, Y., Aas, T., & Lønning, P. E. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5221 · Cited by 140 · see citing works

Complexities of androgen receptor signalling in breast cancer

McNamara, K. M., Moore, N. L. T., Hickey, T. E., Sasano, H., & Tilley, W. D. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0243 · Cited by 134 · see citing works

Aromatase Localization in Human Breast Cancer Tissues: Possible Interactions between Intratumoral Stromal and Parenchymal Cells

Miki, Y., Suzuki, T., Tazawa, C., Yamaguchi, Y., Kitada, K., Honma, S., Moriya, T., Hirakawa, H., Evans, D. B., Hayashi, S., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3105 · Cited by 133 · see citing works

Targeting Aromatase and Estrogen Signaling in Human Non‐Small Cell Lung Cancer

Márquez‐Garbán, D. C., Chen, H., Goodglick, L., Fishbein, M. C., & Pietras, R. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04116.x · Cited by 125 · see citing works

Biological Roles of Estrogen and Progesterone in Human Endometrial Carcinoma - New developments in potential endocrine therapy for endometrial cancer -

Ito, K., Utsunomiya, H., Yaegashi, N., & Sasano, H. (2007) · Endocrine Journal · doi:10.1507/endocrj.kr-114 · Cited by 122 · see citing works

Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor–Positive and -Negative Breast Cancer: a Nested Case–Control Study

James, R. E., Lukanova, A., Dossus, L., Becker, S., Rinaldi, S., Tjønneland, A. M., Olsen, A., Overvad, K., Mesrine, S., Engel, P., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0090 · Cited by 122 · see citing works

Aldo–keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

Byrns, M. C., Duan, L., Lee, S. H., Blair, I. A., & Penning, T. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.009 · Cited by 116 · see citing works

Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells

Garcia, V. A., González, A., Alonso‐González, C., Martínez‐Campa, C., & Cos, S. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12007 · Cited by 106 · see citing works

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

Knutson, T. P., Daniel, A. R., Fan, D., Silverstein, K. A. T., Covington, K. R., Fuqua, S. A. W., & Lange, C. A. (2012) · Breast Cancer Research · doi:10.1186/bcr3211 · Cited by 99 · see citing works

Intracrinology of estrogens and androgens in breast carcinoma

Sasano, H., Suzuki, T., Miki, Y., & Moriya, T. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.012 · Cited by 93 · see citing works

Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells

Martínez‐Campa, C., González, A., Mediavilla, M. D., Alonso‐González, C., Garcia, V. A., Sánchez‐Barceló, E. J., & Cos, S. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605336 · Cited by 90 · see citing works

In situ estrogen production and its regulation in human breast carcinoma: From endocrinology to intracrinology

Sasano, H., Miki, Y., Nagasaki, S., & Suzuki, T. (2009) · Pathology International · doi:10.1111/j.1440-1827.2009.02444.x · Cited by 86 · see citing works

Melatonin as a Selective Estrogen Enzyme Modulator

Cos, S., González, A., Martínez‐Campa, C., Mediavilla, M., Alonso‐González, C., & Sánchez‐Barceló, E. J. (2008) · Current Cancer Drug Targets · doi:10.2174/156800908786733469 · Cited by 83 · see citing works

Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): Role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs

Byrns, M. C., & Penning, T. M. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.024 · Cited by 82 · see citing works

Role of melatonin in the epigenetic regulation of breast cancer

Korkmaz, A., Sánchez‐Barceló, E. J., Tan, D., & Reiter, R. J. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0103-5 · Cited by 78 · see citing works

5α‐Reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production

Suzuki, T., Miki, Y., Moriya, T., Akahira, J., Ishida, T., Hirakawa, H., Yamaguchi, Y., Hayashi, S., & Sasano, H. (2006) · International Journal of Cancer · doi:10.1002/ijc.22317 · Cited by 78 · see citing works

17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production

Aka, J. A., Mazumdar, M., Chen, C., Poirier, D., & Lin, S. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0468 · Cited by 78 · see citing works

Low-dose environmental endocrine disruptors, increase aromatase activity, estradiol biosynthesis and cell proliferation in human breast cells

Williams, G. P., & Darbre, P. D. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.02.016 · Cited by 77 · see citing works

Molecular mechanisms of melatonin’s inhibitory actions on breast cancers

Proietti, S., Cucina, A., Reiter, R. J., & Bizzarri, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1161-8 · Cited by 75 · see citing works

Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast

Shibuya, R., Suzuki, T., Miki, Y., Yoshida, K., Moriya, T., Ono, K., Akahira, J., Ishida, T., Hirakawa, H., EVANS, D. B., et al. (2008) · Endocrine Related Cancer · doi:10.1677/erc-07-0092 · Cited by 75 · see citing works

Fulvestrant

Croxtall, J. D., & McKeage, K. (2011) · Drugs · doi:10.2165/11204810-000000000-00000 · Cited by 72 · see citing works

17β-Hydroxysteroid Dehydrogenase 14 Affects Estradiol Levels in Breast Cancer Cells and Is a Prognostic Marker in Estrogen Receptor–Positive Breast Cancer

Jansson, A., Gunnarsson, C., Cohen, M., Sivik, T., & Stål, O. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1448 · Cited by 73 · see citing works

Novel roles of prolactin and estrogens in breast cancer: resistance to chemotherapy

LaPensee, E. W., & Ben‐Jonathan, N. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0253 · Cited by 72 · see citing works

Expression of Aromatase and Estrogen Sulfotransferase in Eutopic and Ectopic Endometrium: Evidence for Unbalanced Estradiol Production in Endometriosis

Hudelist, G., Czerwenka, K., Keckstein, J., Haas, C., Fink-Retter, A., Gschwantler-Kaulich, D., Kubista, E., & Singer, C. F. (2007) · Reproductive Sciences · doi:10.1177/1933719107309120 · Cited by 70 · see citing works

The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women

Danforth, K. N., Eliassen, A. H., Tworoger, S. S., Missmer, S. A., Barbieri, R. L., ROSNER, B. A., Colditz, G. A., & Hankinson, S. E. (2009) · International Journal of Cancer · doi:10.1002/ijc.24709 · Cited by 70 · see citing works

LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer

Sakurai, M., Miki, Y., Masuda, M., Hata, S., Shibahara, Y., Hirakawa, H., Suzuki, T., & Sasano, H. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.10.007 · Cited by 69 · see citing works

Increased androgen receptor activity and cell proliferation in aromatase inhibitor-resistant breast carcinoma

Fujii, R., Hanamura, T., Suzuki, T., Gohno, T., Shibahara, Y., Niwa, T., Yamaguchi, Y., Ohnuki, K., Kakugawa, Y., Hirakawa, H., et al. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.08.019 · Cited by 67 · see citing works

Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism

Purohit, A., Woo, L. W. L., & Potter, B. V. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.012 · Cited by 68 · see citing works

Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor

Suzuki, T., Inoue, A., Miki, Y., Moriya, T., Akahira, J., Ishida, T., Hirakawa, H., Yamaguchi, Y., Hayashi, S., & Sasano, H. (2007) · Endocrine Related Cancer · doi:10.1677/erc-06-0005 · Cited by 67 · see citing works

Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17

Hu, D. G., Selth, L. A., Tarulli, G. A., Meech, R., Wijayakumara, D., Chanawong, A., Russell, R., Caldas, C., Robinson, J. L. L., Carroll, J. S., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3372 · Cited by 59 · see citing works

Melatonin promotes differentiation of 3T3‐L1 fibroblasts

González, A., Garcia, V. A., Martínez‐Campa, C., Alonso‐González, C., & Cos, S. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00911.x · Cited by 58 · see citing works

Analyzing the regulation of metabolic pathways in human breast cancer

Schramm, G., Surmann, E.-M., Wiesberg, S., Oswald, M., Reinelt, G., Eils, R., & König, R. (2010) · BMC Medical Genomics · doi:10.1186/1755-8794-3-39 · Cited by 56 · see citing works

Selective estrogen enzyme modulator actions of melatonin in human breast cancer cells

González, A., Cos, S., Martínez‐Campa, C., Alonso‐González, C., Sánchez, S., Mediavilla, M. D., & Sánchez‐Barceló, E. J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00559.x · Cited by 56 · see citing works

Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine production

Garcia, V. A., González, A., Alonso‐González, C., Martínez‐Campa, C., & Cos, S. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00940.x · Cited by 55 · see citing works

17β-hydroxysteroid dehydrogenases in human endometrium and its disorders

Ito, K., Utsunomiya, H., Suzuki, T., Saitou, S., Akahira, J.-I., Okamura, K., Yaegashi, N., & Sasano, H. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.038 · Cited by 54 · see citing works

Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis

Sutherland, R., Meeson, A. P., & Lowes, S. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09879-6 · Cited by 54 · see citing works

New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent Diseases

Marchais‐Oberwinkler, S., Wetzel, M., Ziegler, E., Kruchten, P., Werth, R., Henn, C., Hartmann, R. W., & Frotscher, M. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1009082 · Cited by 53 · see citing works

Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells

Zhang, Y., Qian, R.-Q., & Li, P. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.008 · Cited by 52 · see citing works

Androgen receptor: A promising therapeutic target in breast cancer

Vasiliou, S. K., & Diamandis, E. P. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1575643 · Cited by 52 · see citing works

Androgens in human breast carcinoma

Suzuki, T., Miki, Y., Takagi, K., Hirakawa, H., Moriya, T., Ohuchi, N., & Sasano, H. (2010) · Medical Molecular Morphology · doi:10.1007/s00795-010-0494-3 · Cited by 50 · see citing works

Prostaglandin E2 Inhibits p53 in Human Breast Adipose Stromal Cells: A Novel Mechanism for the Regulation of Aromatase in Obesity and Breast Cancer

Wang, X., Docanto, M. M., Sasano, H., Lo, C. Y.-W., Simpson, E. R., & Brown, K. A. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2164 · Cited by 48 · see citing works

Anastrozole

Sanford, M., & Plosker, G. L. (2008) · Drugs · doi:10.2165/00003495-200868090-00007 · Cited by 49 · see citing works

Activation of Aromatase Expression by Retinoic Acid Receptor-related Orphan Receptor (ROR) α in Breast Cancer Cells

Odawara, H., Iwasaki, T., Horiguchi, J., Rokutanda, N., Hirooka, K., Miyazaki, W., Koibuchi, Y., Shimokawa, N., Iino, Y., Takeyoshi, I., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009241 · Cited by 48 · see citing works

Evidence for the Existence of Triple-Negative Variants in the MCF-7 Breast Cancer Cell Population

Leung, E. Y., Kim, J. E., Askarian-Amiri, M., Finlay, G. J., & Baguley, B. C. (2014) · BioMed Research International · doi:10.1155/2014/836769 · Cited by 47 · see citing works

Aromatase and estrogen receptor alpha mRNA expression as prognostic biomarkers in patients with astrocytomas

Jiménez, J. M. D., Arellano, A. C., Santerre, A., Orozco-Suárez, S. A., Sánchez, H. S., Romero, I. F., López-Elizalde, R., Venegas, M. A., Netel, B., de la Torre-Valdovinos, B., et al. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1509-z · Cited by 47 · see citing works

Hormone Replacement Therapy and Cancers: The Biological Roles of Estrogen and Progestin in Tumorigenesis are Different between the Endometrium and Breast

Ito, K. (2007) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.212.1 · Cited by 45 · see citing works

Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity

Bhattacharyya, S., & Tobacman, J. K. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.08.002 · Cited by 45 · see citing works

In situ production of sex steroids in human breast carcinoma

Suzuki, T., Miki, Y., Moriya, T., Akahira, J., Hirakawa, H., Ohuchi, N., & Sasano, H. (2007) · Medical Molecular Morphology · doi:10.1007/s00795-007-0365-8 · Cited by 43 · see citing works

17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis

Nagasaki, S., Suzuki, T., Miki, Y., Akahira, J., Kitada, K., Ishida, T., Handa, H., Ohuchi, N., & Sasano, H. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-0821 · Cited by 42 · see citing works

Suppression of estrogen actions in human lung cancer

Miki, Y., Abe, K., Suzuki, S., Suzuki, T., & Sasano, H. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.02.018 · Cited by 40 · see citing works

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers

Rižner, T. L., Thalhammer, T., & Özvegy‐Laczka, C. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00346 · Cited by 40 · see citing works

Aromatase in Human Breast Carcinoma as a Key Regulator of Intratumoral Sex Steroid Concentrations

Suzuki, T., Miki, Y., Akahira, J., Moriya, T., Ohuchi, N., & Sasano, H. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-053 · Cited by 39 · see citing works

Steroid sulfatase and estrogen sulfotransferase in human carcinomas

Suzuki, T., Miki, Y., Nakamura, Y., Ito, K., & Sasano, H. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.001 · Cited by 39 · see citing works

Exemestane

Deeks, E. D., & Scott, L. J. (2009) · Drugs · doi:10.2165/00003495-200969070-00007 · Cited by 39 · see citing works

The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma

Tanaka, S., Miki, Y., Hashimoto, C., Takagi, K., Doe, Z., Li, B., Yaegashi, N., Suzuki, T., & Ito, K. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.022 · Cited by 38 · see citing works

Steroid metabolism in breast cancer: Where are we and what are we missing?

Africander, D., & Storbeck, K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.016 · Cited by 39 · see citing works

Emerging Concepts of Apolipoprotein D with Possible Implications for Breast Cancer

Søiland, H., Søreide, K., Janssen, E. A. M., Kørner, H., Baak, J. P. A., & Søreide, J. A. (2007) · Analytical Cellular Pathology · doi:10.1155/2007/487235 · Cited by 38 · see citing works

The Contribution of 17beta-Hydroxysteroid Dehydrogenase Type 1 to the Estradiol-Estrone Ratio in Estrogen-Sensitive Breast Cancer Cells

Zhang, C., Chen, J., Yin, D., & Lin, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029835 · Cited by 35 · see citing works

New cancer drugs targeting the biosynthesis of estrogens and androgens

Poirier, D. (2008) · Drug Development Research · doi:10.1002/ddr.20263 · Cited by 36 · see citing works

Human breast cancer stem cells and sex hormones-a narrative review

Eden, J. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181d3cdd7 · Cited by 35 · see citing works

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

Khanim, F. L., Davies, N., Veliça, P., Hayden, R., Ride, J. P., Pararasa, C., Chong, M., Günther, U. L., Veerapen, N., Winn, P. J., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.83 · Cited by 35 · see citing works

Melatonin modulation of crosstalk among malignant epithelial, endothelial and adipose cells in breast cancer (Review)

Cos, S., Garcia, V. A., González, A., Alonso‐González, C., & Martínez‐Campa, C. (2014) · Oncology Letters · doi:10.3892/ol.2014.2203 · Cited by 35 · see citing works

Intratumoral estrogen production in breast carcinoma: significance of aromatase

Suzuki, T., Miki, Y., Ohuchi, N., & Sasano, H. (2008) · Breast Cancer · doi:10.1007/s12282-008-0062-z · Cited by 35 · see citing works

The vitamin D receptor‐mediated activation of phosphatidylinositol 3‐kinase (PI3Kα) plays a role in the 1α,25‐dihydroxyvitamin D3‐stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines

Hughes, P., Lee, J. S., Reiner, N. E., & Brown, G. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21545 · Cited by 34 · see citing works

Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism

Docanto, M. M., Yang, F., Callaghan, B. P., Au, C. C., Ragavan, R., Wang, X., Furness, J. B., Andrews, Z. B., & Brown, K. A. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3060-1 · Cited by 34 · see citing works

Redox regulation of human estrogen sulfotransferase (hSULT1E1)

Maiti, S., Zhang, J., & Chen, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.12.026 · Cited by 32 · see citing works

17β hydroxysteroid dehydrogenase type 12 (HSD17B12) is a marker of poor prognosis in ovarian carcinoma

Szajnik, M. E., Szczepański, M. J., Elishaev, E., Visús, C., Lenzner, D. E., Zabel, M., Glura, M., DeLeo, A. B., & Whiteside, T. L. (2012) · Gynecologic Oncology · doi:10.1016/j.ygyno.2012.08.010 · Cited by 31 · see citing works

17β‐Hydroxysteroid Dehydrogenases in Human Breast Cancer

Nagasaki, S., Miki, Y., Akahira, J., Suzuki, T., & Sasano, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03682.x · Cited by 31 · see citing works

Activities of steroid metabolic enzymes in secretory endometria from untreated women with Polycystic Ovary Syndrome

León, L. E., Bacallao, K., Gabler, F., Romero, C., Valladares, L., & Vega, M. (2007) · Steroids · doi:10.1016/j.steroids.2007.09.003 · Cited by 31 · see citing works

Immunolocalization of estrogen‐producing and metabolizing enzymes in benign breast disease: Comparison with normal breast and breast carcinoma

Sasaki, Y., Miki, Y., Hirakawa, H., Onodera, Y., Takagi, K., Akahira, J., Honma, S., Ishida, T., Watanabe, M., Sasano, H., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01673.x · Cited by 30 · see citing works

Effects of cytokines derived from cancer-associated fibroblasts on androgen synthetic enzymes in estrogen receptor-negative breast carcinoma

Kikuchi, K., McNamara, K. M., Miki, Y., Moon, J.-Y., Choi, M. H., Omata, F., Sakurai, M., Onodera, Y., Rai, Y., Ohi, Y., et al. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4464-5 · Cited by 29 · see citing works

Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma.

(2010) · Europe PMC (PubMed Central) · Cited by 29 · see citing works

FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice

Thompson, M. G., Peiffer, D. S., Larson, M., Navarro, F. C., & Watkins, S. K. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-1972-4 · Cited by 28 · see citing works

ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens

Takagi, K., Miki, Y., Onodera, Y., Ishida, T., Watanabe, M., Sasano, H., & Suzuki, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030804 · Cited by 28 · see citing works

In Vivo Inhibition of the Estrogen Sulfatase Enzyme and Growth of DMBA-Induced Mammary Tumors by Melatonin

González, A., Garcia, V. A., Martínez‐Campa, C., Mediavilla, M. D., Alonso‐González, C., Sánchez‐Barceló, E. J., & Cos, S. (2010) · Current Cancer Drug Targets · doi:10.2174/156800910791190201 · Cited by 28 · see citing works

Controversies of aromatase localization in human breast cancer—Stromal versus parenchymal cells

Miki, Y., Suzuki, T., & Sasano, H. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.05.007 · Cited by 27 · see citing works

Roles of steroid sulfatase in brain and other tissues

Kříž, L., Bičı́ková, M., & Hampl, R. (2008) · Physiological Research · doi:10.33549/physiolres.931207 · Cited by 27 · see citing works

Measurement of Sex Steroid Hormones in Breast Adipocytes: Methods and Implications

Falk, R. T., Gentzschein, E., Stanczyk, F. Z., Brinton, L. A., García‐Closas, M., Ioffe, O. B., & Sherman, M. E. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0119 · Cited by 26 · see citing works

Synthesis of Libraries of 16β‐Aminopropyl Estradiol Derivatives for Targeting Two Key Steroidogenic Enzymes

Ciobanu, L. C., & Poirier, D. (2006) · ChemMedChem · doi:10.1002/cmdc.200600071 · Cited by 25 · see citing works

Effects of black cohosh on estrogen biosynthesis in normal breast tissue in vitro

Stute, P., Nißlein, T., Götte, M., Kamischke, A., Kiesel, L., & Klockenbusch, W. (2007) · Maturitas · doi:10.1016/j.maturitas.2007.04.007 · Cited by 25 · see citing works

Breast cancer, stem cells and sex hormones. Part 2: The impact of the reproductive years and pregnancy

Eden, J. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.07.012 · Cited by 24 · see citing works

Melatonin and Melatonergic Drugs in Clinical Practice

Srinivasan, V. J., Shillcutt, S. D., Öter, Ş., & Brzezinski, A. (2014) · Springer eBooks · doi:10.1007/978-81-322-0825-9 · Cited by 22 · see citing works

Hormonothérapie des cancers du sein

de Crémoux, P. (2011) · Bulletin du Cancer · doi:10.1684/bdc.2011.1466 · Cited by 20 · see citing works

Androgen receptor and 5α-reductase immunohistochemical profiles in extramammary Paget disease

Kasashima, S., Ozaki, S., Kawashima, A., Zen, Y., Moriya, T., & Inoue, M. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09603.x · Cited by 20 · see citing works

Lactogens and estrogens in breast cancer chemoresistance

Idelman, G., Jacobson, E. M., Tuttle, T. R., & Ben‐Jonathan, N. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.19 · Cited by 20 · see citing works

Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6)

Karakus, E., Zahner, D., Grosser, G., Leidolf, R., Gündoğdu, C., Sánchez‐Guijo, A., Wudy, S. A., & Geyer, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00941 · Cited by 20 · see citing works

Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer

Hudelist, G., Wülfing, P., Kersting, C., Buerger, H., Mattsson, B., Czerwenka, K. F., Kubista, E., Gschwantler‐Kaulich, D., Fink-Retter, A., & Singer, C. F. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0249-2 · Cited by 20 · see citing works

Shu-Gan-Liang-Xue Decoction, a Chinese herbal formula, down-regulates the expression of steroid sulfatase genes in human breast carcinoma MCF-7 cells

Zhang, Y., & Li, P. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.12.014 · Cited by 19 · see citing works

Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase

Roy, J., Lefebvre, J., Maltais, R., & Poirier, D. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.022 · Cited by 19 · see citing works

Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones

Toit, R. L.-D., Storbeck, K., Cartwright, M., Cabral, A., & Africander, D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.004 · Cited by 19 · see citing works

Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208

Ji, X., Chen, G.-P., Song, Y., Hua, M., Wang, L., Li, L., Yuan, Y., Wang, S., Zhou, T., & Lu, W. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.14 · Cited by 19 · see citing works

Estradiol dimers as a new class of steroid sulfatase reversible inhibitors

Fournier, D., & Poirier, D. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.12.047 · Cited by 19 · see citing works

Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: An underlying mechanism

Sang, X., Han, H., Poirier, D., & Lin, S. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.05.009 · Cited by 18 · see citing works

Clinical Studies on Hormonal Status in Breast Cancer and its Impact on Quality of Life(QOL)

Jamil, K., Kumar, K., Fatima, S. H., Rabbani, S., Kumar, R., & Perimi, R. (2009) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000013 · Cited by 18 · see citing works

Sex steroid-producing enzymes in human breast cancer Takashi Suzuki, Yasuhiro Miki, Yasuhiro Nakamura, Takuya Moriya,

Kiyoshi, I., Ohuchi, N., & Sasano, H. (2013)

In situ production of sex steroids in human breast carcinoma

Suzuki, T., Miki, Y., Moriya, T., Akahira, J., Hirakawa, H., Ohuchi, N., & Sasano, H. (2007) · Medical Molecular Morphology · doi:10.1007/s00795-007-0365-8 · Cited by 43 · see citing works

Intratumoral estrogen production in breast carcinoma: significance of aromatase

Suzuki, T., Miki, Y., Ohuchi, N., & Sasano, H. (2008) · Breast Cancer · doi:10.1007/s12282-008-0062-z · Cited by 35 · see citing works

In situ production of estrogens in human breast carcinoma

Suzuki, T., Moriya, T., Ishida, T., Kimura, M., Ohuchi, N., & Sasano, H. (2002) · Breast Cancer · doi:10.1007/bf02967607 · Cited by 21 · see citing works

乳癌におけるエストロゲン合成 : アロマターゼの重要性

鈴木, 貴. (2007) · Institutional Repositories DataBase (IRDB)