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Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma.
Abstract
The in situ formation of estradiol plays an important role in the development and biological behavior of human breast cancer Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 (17 beta-HSD type 1) are two principal enzymes involved in in situ estradiol production. We evaluated the expression of aromatase and 17 beta-HSD type 1 by immunohistochemistry in 41 cases of invasive breast carcinoma (19 lobular and 22 ductal). We then examined the correlation among the expression of these enzymes, estrogen (ER) and progesterone (PR) receptor status, Ki67 labeling index of carcinoma cells, age, and the clinical stage of the patients. Marked aromatase immunoreactivity was observed in stromal cells around carcinomatous glands in 32 of 41 cases (78%), and 17 beta-HSD type 1 immunoreactivity was detected in carcinoma cells in 23 of 41 cases (56%). There was a significant correlation observed between expression of 17 beta-HSD type 1 and aromatase in invasive lobular carcinoma (P = 0.0119), but not in invasive ductal carcinoma. There was an inverse correlation between aromatase and ER status in invasive ductal carcinoma (P = 0.0213), but not in invasive lobular carcinoma. No other correlations were observed among 17 beta-HSD type 1, aromatase, PR, ER, clinical stage, age, and Ki67 labeling indexes. Aromatase and 17 beta-HSD are not always expressed simultaneously in human breast carcinoma, but their simultaneous expression is more frequent in invasive lobular carcinoma than invasive ductal carcinoma. Consequently, different mechanisms may be involved in the regulation of expression of these two enzymes in human breast carcinoma.
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“Nevertheless, 17HSD1 is probably critical for ovulation and may be important in the pathogenesis and progression of estrogen-dependent breast cancers (512).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [512]
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Cites
Sastre‐Garau, X., Jouve, M., Asselain, B. J. R., Vincent‐Salomon, A., Beuzeboc, P., Dorval, T., Durand, J. C., Fourquet, A., & Pouillart, P. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960101)77:1 · Cited by 422
Infiltrating lobular carcinoma of the breast
Dixon, J. M., Anderson, T. J., Page, D. L., Lee, D., & Duffy, S. W. (1982) · Histopathology · doi:10.1111/j.1365-2559.1982.tb02712.x · Cited by 227
Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer.
Dutta, A., Chandra, R., Leiter, L. M., & Lester, S. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5386 · Cited by 160
Stromal spindle cells contain aromatase in human breast tumors
Santen, R. J., Martel, J., Hoagland, M. S., Naftolin, F. N., Roa, L., Harada, N., Hafer, L. J., Zaino, R. J., & Santner, S. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045987 · Cited by 153
Self-citationWatanabe, K., Sasano, H., Harada, N., Ozaki, M., Niikura, H., Sato, S., & Yajima, A. (1995) · Europe PMC (PubMed Central) · Cited by 122
Self-citationDixon, J. M., Anderson, T. J., Page, D. L., Lee, D., Duffy, S. W., & Stewart, H. (1983) · British journal of surgery · doi:10.1002/bjs.1800700902 · Cited by 117
POUTANEN, M. H., ISOMAA, V. V., Lehto, V. P., & Vihko, R. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910500310 · Cited by 116
Self-citationIntratumoral aromatase as a prognostic factor in human breast carcinoma.
Mc, S., Mg, R., Dowsett, M., Gusterson, B. A., McKinna, J. A., Fryatt, I., & Coombes, R. C. (1989) · PubMed · Cited by 107
Regulation of aromatase expression in human tissues
Bulun, S. E., & Simpson, E. R. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00682738 · Cited by 105
Self-citationSasano, H., Kimura, M., Shizawa, S., Kimura, N., & Nagura, H. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768875 · Cited by 83
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The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458
Simpson, E. R., Clyne, C., Rubin, G., Boon, W. C., Robertson, K., Britt, K., Speed, C., & Jones, M. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081601.142703 · Cited by 773
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620
Bulun, S. E., Lin, Z., Imir, G., Amin, S., Demura, M., Yilmaz, B., Martin, R., Utsunomiya, H., Thung, S., Gurates, B., et al. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.3.6 · Cited by 531
Self-citationHistory of Aromatase: Saga of an Important Biological Mediator and Therapeutic Target
Santen, R. J., Brodie, H. J., Simpson, E. R., Siiteri, P. K., & Brodie, A. M. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0016 · Cited by 447
Zeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Andersson, S., Johns, A., Meng, L., Putman, M., Carr, B., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5301 · Cited by 308
Self-citationPeltoketo, H., Luu-The, V, Simard, J., & Adamski, J. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0230001 · Cited by 302
Aromatase in Human Bone Tissue
Sasano, H., Uzuki, M., Sawai, T., Nagura, H., Matsunaga, G., Kashimoto, O., & Harada, N. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.9.1416 · Cited by 268
Self-citationChapter 5: Tissue-Specific Synthesis and Oxidative Metabolism of Estrogens
Jefcoate, C. R. E., Liehr, J. G., Santen, R. J., Sutter, T. R., Yager, J. D., Yue, W., Santner, S. J., TEKMAL, R. R., Demers, L. M., Pauley, R. J., et al. (2000) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a024248 · Cited by 260
Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells
Russo, J., Lareef, M. H., Balogh, G., Guo, S., & Russo, I. H. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00390-x · Cited by 252
The role of local estrogen Biosynthesis in males and females
Simpson, E., Rubin, G., Clyne, C., Robertson, K., O’Donnell, L., Jones, M., & Davis, S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00254-x · Cited by 249
Aromatase, breast cancer and obesity: a complex interaction
Bulun, S. E., Chen, D., Moy, I., Brooks, D. C., & Zhao, H. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.10.003 · Cited by 224
Self-citationIntratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies
Sasano, H., & Harada, N. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0342 · Cited by 223
Self-citationLocal estrogen biosynthesis in males and females.
Simpson, E. R., Rubin, G., Clyne, C. D., Robertson, K. M.-P., O’Donnell, L., Davis, S. R., & Jones, M. E. E. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060131 · Cited by 199
Phytoestrogens and breast cancer –promoters or protectors?
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Self-citationHydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action
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Role of aromatase in sex steroid action
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Breast cancer tissue estrogens and their manipulation with aromatase inhibitors and inactivators
Geisler, J. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00364-9 · Cited by 133
Suzuki, T., Moriya, T., Ariga, N., Kaneko, C., Kanazawa, M., & Sasano, H. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.0956 · Cited by 130
Self-citationAdriaenssens, É., Dumont, L., Lottin, S., Bolle, D., Alain Leprêtre, A., Delobelle, A., Bouali, F., Dugimont, T., Coll, J., & Curgy, J. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65748-3 · Cited by 127
17β-Hydroxysteroid Dehydrogenase Type 1 Is an Independent Prognostic Marker in Breast Cancer
Oduwole, O. O., Yan, L., ISOMAA, V. V., Mäntyniemi, A., Pulkka, A. E., Soini, Y., & Vihko, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0446 · Cited by 117
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Geisler, J., & Lønning, P. E. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2187 · Cited by 117
Gunnarsson, C., Olsson, B., & Stål, O. (2001) · PubMed · Cited by 105
the Southeast Sweden Breast Cancer Group, Gunnarsson, C., Hellqvist, E., & Stål, O. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602375 · Cited by 97
Progesterone production and actions in the human central nervous system and neurogenic tumors
Inoue, T., Akahira, J.-I., Suzuki, T., Darnel, A. D., Kaneko, C., Takahashi, K., Hatori, M., Shirane, R., Kumabe, T., Kurokawa, Y., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-012096 · Cited by 96
Self-citationAndrogens and mammary growth and neoplasia
Dimitrakakis, C., Zhou, J., & Bondy, C. A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02979-5 · Cited by 97
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Self-citationAromatase excess in cancers of breast, endometrium and ovary
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Self-citationRegulation of aromatase expression in breast cancer tissue
Bulun, S. E., Lin, Z., Zhao, H., Lu, M., Amin, S., Reierstad, S., & Chen, D. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.03705.x · Cited by 83
Self-citationAmplification of HSD17B1 and ERBB2 in primary breast cancer
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Gingras, S., Moriggl, R., Groner, B., & Simard, J. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.1.0221 · Cited by 77
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Utsunomiya, H., Cheng, Y.-H., Lin, Z., Reierstad, S., Yin, P., Attar, E., Xue, Q., Imir, G., Thung, S., Trukhacheva, E., et al. (2008) · Molecular Endocrinology · doi:10.1210/me.2006-0302 · Cited by 72
Self-citation5 -Reductases in Human Breast Carcinoma: Possible Modulator of in Situ Androgenic Actions
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Self-citationHudelist, G., Czerwenka, K., Keckstein, J., Haas, C., Fink-Retter, A., Gschwantler-Kaulich, D., Kubista, E., & Singer, C. F. (2007) · Reproductive Sciences · doi:10.1177/1933719107309120 · Cited by 70
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Eyre, L. J., Bland, R., Bujalska, I. J., Sheppard, M. C., Stewart, P. M., & Hewison, M. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.6.996 · Cited by 52
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Karkola, S., Lilienkampf, A., & Wähälä, K. (2008) · ChemMedChem · doi:10.1002/cmdc.200700271 · Cited by 35
Jansson, A., Delander, L., Gunnarsson, C., Fornander, T., Skoog, L. K., Nordenskjöld, B. A., & Stål, O. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2599 · Cited by 34
Differential expression of steroidogenic enzymes according to endometriosis type
Colette, S., Defrère, S., Kerk, O. V., Langendonckt, A. V., Dolmans, M., & Donnez, J. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.003 · Cited by 36
Amplification of HSD17B1 has prognostic significance in postmenopausal breast cancer
Gunnarsson, C., Jerevall, P.-L., Hammar, K., Olsson, B., Nordenskjöld, B. A., Jansson, A., & Stål, O. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9579-7 · Cited by 34
Sasano, H., Suzuki, T., Matsuzaki, Y., Fukaya, T., Endoh, M., Nagura, H., & Kimura, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5435 · Cited by 34
Self-citationMaltais, R., Ayan, D. P., Trottier, A., Barbeau, X., Lagüe, P., Bouchard, J., & Poirier, D. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401639v · Cited by 33
Biology of Aromatase in the Mammary Gland
Simpson, E. R. (2000) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1009590626450 · Cited by 34
17β-Hydroxysteroid dehydrogenases and cancers
Vihko, P., Härkönen, P. K., Oduwole, O. O., Törn, S., Kurkela, R., Porvari, K., Pulkka, A. E., & ISOMAA, V. V. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00278-9 · Cited by 33
Friesenhengst, A., Pribitzer-Winner, T., Miedl, H., Proestling, K., & Schreiber, M. (2018) · Hormones and Cancer · doi:10.1007/s12672-017-0317-2 · Cited by 32
17β‐Hydroxysteroid Dehydrogenases in Human Breast Cancer
Nagasaki, S., Miki, Y., Akahira, J., Suzuki, T., & Sasano, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03682.x · Cited by 31
Self-citationIto, K., Suzuki, T., Moriya, T., Utsunomiya, H., Sugawara, A., Konno, R., Sato, S., & Sasano, H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7546 · Cited by 31
Self-citationDeluca, D., Möller, G., Rosinus, A., Elger, W. A. G., Hillisch, A., & Adamski, J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.037 · Cited by 31
Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells
Turgeon, C., Gingras, S., Carrière, M., Blais, Y., Labrie, F., & Simard, J. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00031-4 · Cited by 31
Oestrogen-synthesising enzymes and breast cancer.
Kulendran, M., Salhab, M., & Mokbel, K. (2009) · PubMed · Cited by 30
Marchais‐Oberwinkler, S., Frotscher, M., Ziegler, E., Werth, R., Kruchten, P., Messinger, J., Thole, H., & Hartmann, R. W. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.024 · Cited by 29
Aromatase inhibitors in the treatment of early and advanced breast cancer
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Girault, I., Lerebours, F., Tozlu, S., Spyratos, F., Tubiana-Hulin, M., Lidereau, R., & Bièche, I. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00190-5 · Cited by 29
Metadata
- Authors
- Sasano, H., Frost, A. R., Saitoh, R., Harada, N., Poutanen, M., Vihko, R., Bulun, S. E., Silverberg, S. G., & Nagura, H.
- Affiliations
- Tohoku University (JP)
- George Washington University (US)
- Fujita Health University (JP)
- The University of Texas at Dallas (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1996-11
- Volume
- 81
- Issue
- 11
- Pages
- 4042-4046
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1993913378
- Cited by
- 167
- References
- 17
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- aromatase, breast cancer, invasive lobular carcinoma, invasive ductal carcinoma, estrogen receptor, progesterone receptor, Ki-67 proliferation index, tumor stroma
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aromatase, Breast Neoplasms, Estradiol, Female, Humans, Immunohistochemistry, Middle Aged, Receptors, Estrogen, Receptors, Progesterone, 17-Hydroxysteroid Dehydrogenases, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Ki-67 Antigen
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