Cited by 792Hormonal and reproductive studiesBone health and osteoporosis researchGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.

Katznelson, L, Finkelstein, J S, Schoenfeld, D A, Rosenthal, D I, Anderson, E J, Klibanski, A·1996·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.81.12.8954042

Open this paper in CoChat — free account

Abstract

Acquired hypogonadism is being increasingly recognized in adult men. However, the effects of long term testosterone replacement on bone density and body composition are largely unknown. We investigated 36 adult men with acquired hypogonadism (age, 22-69 yr; median, 58 yr), including 29 men with central hypogonadism and 7 men with primary hypogonadism, and 44 age-matched eugonadal controls. Baseline evaluation included body composition analysis by bioimpedance, determination of site-specific adipose area by dual energy quantitative computed tomography scan (QCT) of the lumbar spine, and measurements of spinal bone mineral density (BMD) using dual energy x-ray absortiometry, spinal trabecular BMD with QCT, and radial BMD with single photon absorptiometry. Percent body fat was significantly greater in the hypogonadal men compared to eugonadal men (mean +/- SEM, 26.4 +/- 1.1% vs. 19.2 +/- 0.8%; P < 0.01). The mean trabecular BMD determined by QCT for the hypogonadal men was 115 +/- 6 mg K2HPO4/cc. Spinal BMD was significantly lower than that in eugonadal controls (1.006 +/- 0.024 vs. 1.109 +/- 0.028 g/cm2; P = 0.02, respectively). Radial BMD was similar in both groups. Testosterone enanthate therapy was initiated in 29 hypogonadal men at a dose of 100 mg/week, and the subjects were evaluated at 6-month intervals for 18 months. During testosterone therapy, the percent body fat decreased 14 +/- 4% (P < 0.001). There was a 13 +/- 4% decrease in subcutaneous fat (P < 0.01) and a 7 +/- 2% increase in lean muscle mass (P = 0.01) during testosterone therapy. Spinal BMD and trabecular BMD increased by 5 +/- 1% (P < 0.001) and 14 +/- 3% (P < 0.001), respectively. Radial BMD did not change. Serum bone-specific alkaline phosphatase and urinary deoxypyridinoline excretion, markers of bone formation and resorption, respectively, decreased significantly over the 18 months (P = 0.003 and P = 0.04, respectively). We conclude that testosterone therapy given to adult men with acquired hypogonadism decreases sc fat and increases lean muscle mass. In addition, testosterone therapy reduces bone remodeling and increases trabecular bone density. The beneficial effects of androgen administration on body composition and bone density may provide additional indications for testosterone therapy in hypogonadal men.

Integrity signals

Registry

Crossref · 10.1210/jcem.81.12.8954042

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hip fractures in the elderly: A world-wide projection
Cooper, C. C., Campion, G., & Melton, L. J. (1992) · Osteoporosis International · doi:10.1007/bf01623184 · Cited by 3,225
Measurement of Bone Mineral in vivo: An Improved Method
CAMERON, J. R., & Sorenson, J. A. (1963) · Science · doi:10.1126/science.142.3589.230 · Cited by 827
Effects of testosterone supplementation in the aging male.
Tenover, J. S. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400877 · Cited by 702
Risk factors for spinal osteoporosis in men
Seeman, E., Melton, L. J., O’Fallon, W. M., & Riggs, B. L. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90878-1 · Cited by 658
Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis
Urban, R. J., Bodenburg, Y. H., Gilkison, C., Foxworth, J., Coggan, A. R., Wolfe, R. R., & Ferrando, A. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.5.e820 · Cited by 608
Osteoporosis: Etiology, diagnosis, and management
(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80791-1 · Cited by 605
Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567
Effects of Testosterone Replacement Therapy in Old Hypogonadal Males: A Preliminary Study
Morley, J. E., Perry, H. M., Kaiser, F. E., Kraenzle, D., Jensen, J., Houston, K., Mattammal, M. B., & Perry, H. M. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb02049.x · Cited by 462
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.
Bellido, T., Jilka, R. L., Boyce, B. F., Girasole, G., Broxmeyer, H. E., Dalrymple, S. A., Murray, R., & Manolagas, S. C. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117995 · Cited by 429
Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone Remodeling*
Stepan, J. J., Lachman, M., ZVĚŘINA, J., Pacovský, V., & Baylink, D. J. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-523 · Cited by 423

Show all 38 references

Sorted by citations

Items 301–400 of 792

Body Habitus Changes Related to Lipodystrophy
Sattler, F. R. (2003) · Clinical Infectious Diseases · doi:10.1086/367563 · Cited by 43
Androgens, Obesity, and Sleep-Disordered Breathing in Men
Liu, P. Y., Caterson, I. D., Grunstein, R. R., & Handelsman, D. J. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.002 · Cited by 43
“A similar trend was seen in young men who had classical androgen deficiency [56].”
Background
Preventing Bone Loss During Androgen Deprivation Therapy for Prostate Cancer: Early Experience with Neridronate
Magno, C., Anastasi, G., Morabito, N., Gaudio, A., Maisano, D., Franchina, F., Galı̀, A., Frisina, N., & Melloni, D. (2005) · European Urology · doi:10.1016/j.eururo.2005.01.012 · Cited by 43
Influence of castration-induced testosterone and estradiol deficiency on obesity and glucose metabolism in male Göttingen minipigs
Christoffersen, B. Ø., Gade, L. P., Golozoubova, V., Svendsen, O., & Raun, K. (2010) · Steroids · doi:10.1016/j.steroids.2010.04.004 · Cited by 46
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
White, J. P. (2017) · Translational Cancer Research · doi:10.21037/tcr.2017.03.52 · Cited by 45
“Hypogonadism leads to muscle wasting and reduction in functional strength with (39,40) or without (45,46) an underlying disease.”
Background
Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis
Hoffmann, D. B., Komrakova, M., Pflug, S., von Oertzen, M., Saul, D., Weiser, L., Walde, T. A., Waßmann, M., Schilling, A. F., Lehmann, W., et al. (2018) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0929-9 · Cited by 47
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials
Yeap, B. B., Page, S. T., & Grossmann, M. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30416-3 · Cited by 43
Late‐onset Hypogonadism: Bone health
Rochira, V. (2020) · Andrology · doi:10.1111/andr.12827 · Cited by 49
Androgen deficiency: effects on body composition
Miller, K. K. (2008) · Pituitary · doi:10.1007/s11102-008-0121-7 · Cited by 43
“The abdominal subcutaneous fat (SC) is highlighted in white [7].”
Background
Effect of aromatase inhibition on lipids and inflammatory markers of cardiovascular disease in elderly men with low testosterone levels
Dougherty, R. H., Rohrer, J. L., Hayden, D., Rubin, S. D., & Leder, B. Z. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02205.x · Cited by 43
Testosterone and body functions
Köhn, F. M. (2006) · The Aging Male · doi:10.1080/13685530601060396 · Cited by 45
“Men who are hypogonadal due to pituitary or testicular disease have lower bone mineral density (BMD) than eugonadal men [3,4].”
Background
Orchiectomy upregulates free soluble RANKL in bone marrow of aged rats
Proell, V., Xu, H., Schüler, C., Weber, K., Hofbauer, L. C., & Erben, R. G. (2009) · Bone · doi:10.1016/j.bone.2009.05.024 · Cited by 42
Weekly Oral Alendronic Acid in Male Osteoporosis
Miller, P. D., Schnitzer, T. J., Emkey, R. D., et al. (2004) · Clinical Drug Investigation · doi:10.2165/00044011-200424060-00003 · Cited by 42
Evalution of the castrated male Sprague–Dawley rat as a model of the metabolic syndrome and type 2 diabetes
Christoffersen, B. Ø., Raun, K., Svendsen, O., Fledelius, C., & Golozoubova, V. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803261 · Cited by 41
Treatment with oxandrolone and the durability of effects in older men
Schroeder, E. T., Zheng, L., Yarasheski, K. E., Qian, D., Stewart, Y., Flores, C., Martinez, C., Terk, M. R., & Sattler, F. R. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00808.2003 · Cited by 40
“Testosterone treatment in hypogonadal young men increases lean tissue (4, 7, 20, 45, 53, 54) and muscle strength (4, 54) and decreases fat mass (4, 20, 54).”
Background
Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review
Russo, V., Chen, R., & Armamento‐Villareal, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.607240 · Cited by 41
“Increases of in vertebral and hip BMD after T treatment were seen in most studies (52, 55, 56).”
Background
Androgen replacement therapy to reverse and/or prevent age-associated sarcopenia in men
Tenover, J. L. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80153-5 · Cited by 40
Androgen Replacement Therapy
Wang, C., & Swerdloff, R. S. (1997) · Annals of Medicine · doi:10.3109/07853899708999363 · Cited by 40
Oxytocin Reverses Osteoporosis in a Sex-Dependent Manner
Béranger, G. E., Djedaini, M., Battaglia, S., Roux, C. H., Scheideler, M., Heymann, D., Amri, E., & Pisani, D. F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00081 · Cited by 39
“Furthermore, as observed for hypogonadal men (21), testosterone treatment prevents bone loss and body composition changes in these rodents (25).”
Background
Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue
Jiao, Q., Pruznak, A. M., Huber, D. S., Vary, T. C., & Lang, C. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00473.2009 · Cited by 39
Masculine Vitality: Pros and Cons of Testosterone in Treating the Andropause
Asthana, S., Bhasin, S., Butler, R. N., Fillit, H. M., Finkelstein, J. S., Harman, S. M., Holstein, L., Korenman, S. G., Matsumoto, A. M., Morley, J. E., et al. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.5.m461 · Cited by 40
Self-citation
Defining 'relative' androgen deficiency in aging men: how should testosterone be measured and what are the relationships between androgen levels and physical, sexual and emotional health?
Haren, M. T., Morley, J. E., Chapman, I. M., O’Loughlin, P. D., & Wittert, G. (2002) · Climacteric · doi:10.1080/cmt.5.1.15.25 · Cited by 38
Prepubertal Girls with Premature Adrenarche Have Greater Bone Mineral Content and Density Than Controls
Sopher, A. B., Thornton, J. C., Silfen, M. E., Manibo, A. M., Oberfield, S. E., Wang, J., Pierson, R. N., Levine, L. S., & Horlick, M. N. B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8045 · Cited by 38
“Both bone and nonbone lean body mass have been shown to be positively affected by T (14).”
Management of growth hormone deficiency in adults
Nilsson, A. G., Svensson, J., & Johannsson, G. (2007) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2007.05.005 · Cited by 38
Mechanism of the Tissue-Specific Action of the Selective Androgen Receptor Modulator S-101479
Furuya, K., Yamamoto, N., Ohyabu, Y., Morikyu, T., Ishige, H., Albers, M., & Endo, Y. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00885 · Cited by 38
Assessment and clinical management of bone disease in adults with eating disorders: a review
Drabkin, A. D., Rothman, M. S., Wassenaar, E., Mascolo, M., & Mehler, P. S. (2017) · Journal of Eating Disorders · doi:10.1186/s40337-017-0172-0 · Cited by 37
“For example, one study found an impressive spinal BMD increase of 5% and a 7% lean mass increase after 18 months of intramuscular testosterone therapy (100 mg/week) [80].”
Background
Androgen therapy in AIDS wasting
Dobs, A. S. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80096-7 · Cited by 37
Alendronate for osteoporosis in men with androgen-repleted hypogonadism
Shimon, I., Eshed, V., Doolman, R., Sela, B., Karasik, A., & Vered, I. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1879-3 · Cited by 37
“Hypogonadism is associated with low bone mineral density (BMD) and an increased risk of fracture [5, 6, 7]. Testosterone replacement therapy increases BMD in young hypogonadal men [ 8 , 9], as well as in older men with low serum testosterone and BMD similar to the age-adjusted reference male population [10], but it is…”
Background
Treatment of Male Osteoporosis: Recent Advances with Alendronate
Ringe, J. D., ORWOLL, E. S., Daifotis, A. G., & Lombardi, A. (2002) · Osteoporosis International · doi:10.1007/s001980200013 · Cited by 37
“Studies examining the effects of testosterone replacement therapy on BMD in hypogonadal men have shown modest increases in BMD [39–41], but these studies are too small to demonstrate an effect on fracture.”
Bone health in ageing men
David, K., Narinx, N., Antonio, L., Evenepoel, P., Claessens, F., Decallonne, B., & Vanderschueren, D. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09738-5 · Cited by 37
The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men
Maggio, M. G., Vita, F. D., Lauretani, F., Nouvenne, A., Meschi, T., Ticinesi, A., Dominguez, L. J., Barbagallo, M., Dall’Aglio, E., & Ceda, G. P. (2014) · International Journal of Endocrinology · doi:10.1155/2014/525249 · Cited by 36
“The combination of nutritional and hormonal strategies in frail undernourished older people determines a more effective reduction in the number of hospitalizations, the time to hospital admission, and the days of hospital stay [42, 43].”
Background
Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome
Stagi, S., Tommaso, M. D., Manoni, C., Scalini, P., Chiarelli, F., Verrotti, A., Lapi, E., Giglio, S., Dosa, L., & de Martino, M. (2016) · International Journal of Endocrinology · doi:10.1155/2016/3032759 · Cited by 36
Does oestrogen allow women to store fat more efficiently? A biological advantage for fertility and gestation
O’Sullivan, A. (2009) · Obesity and metabolism · doi:10.14341/2071-8713-4880 · Cited by 36
Six-Week Improvements in Muscle Mass and Strength During Androgen Therapy in Older Men
Schroeder, E. T., Vallejo, A. F., Zheng, L., Stewart, Y., Flores, C., Nakao, S., Martinez, C., & Sattler, F. R. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.12.1586 · Cited by 36
Case report: Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity syndrome
Mizunuma, H., Soda, M., Okano, H., Kagami, I., Miyamoto, S., Ohsawa, M., & Ibuki, Y. (1998) · Human Reproduction · doi:10.1093/humrep/13.10.2816 · Cited by 37
“, 1995) and that androgen treatment can increase BMD in men with hypogonadism (Greenspan et al., 1986; Jackson et al., 1987; Katznelson et al., 1996), the aetiology of low BMD of subjects with AIS was thought to be androgen insensitivity (Munoz-Torres et al.”
Background
Androgens and bone metabolism
Finkelstein, J. S. (1998) · Springer eBooks · doi:10.1007/978-3-642-72185-4_6 · Cited by 35
Self-citation
Testosterone Treatment of Pubertal Delay in Duchenne Muscular Dystrophy
Cheetham, T. D., Guglieri, M., Bushby, K. M. D., Owen, C. J., Johnstone, H., Straub, V. W., & Wood, C. L. (2015) · Neuropediatrics · doi:10.1055/s-0035-1563696 · Cited by 35
The diagnosis and treatment of male osteoporosis: Defining, assessing, and preventing skeletal fragility in men
Boonen, S., Kaufman, J., Goemaere, S., Bouillon, R., & Vanderschueren, D. (2007) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2006.09.005 · Cited by 34
“Androgen replacement prevents bone loss and may even increase bone mass in hypogonadal men, at least at trabecular sites [48,103].”
Background
Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
ORWOLL, E. S., & KLEIN, R. F. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50044-6 · Cited by 35
The Effects of Androgen Deprivation Therapy on Lipid Metabolism and Body Composition in Japanese Patients with Prostate Cancer
Torimoto, K., Samma, S., Kagebayashi, Y., Chihara, Y., Tanaka, N., Hirayama, A., Fujimoto, K., & Hirao, Y. (2011) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyr005 · Cited by 34
“Testosterone therapy given to adult men with acquired hypogonadism decreased subcutaneous fat and increased lean muscle mass (18).”
Background
Oral Testosterone in Oil Plus Dutasteride in Men: A Pharmacokinetic Study
Amory, J. K., & Bremner, W. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1221 · Cited by 34
Gender Differences in the Dietary Lard-Induced Increase in Blood Pressure in Rats
Tamaya-Mori, N., Uemura, K., & Iguchi, A. (2002) · Hypertension · doi:10.1161/01.hyp.0000016400.21001.05 · Cited by 34
Monitoring changes in fat-free mass in HIV-positive men with hypotestosteronemia and AIDS wasting syndrome treated with gonadal hormone replacement therapy
Loan, M. D. V., Strawford, A., Jacob, M., et al. (1999) · AIDS · doi:10.1097/00002030-199902040-00012 · Cited by 34
“[34] monitored changes in body composition during an 18-month testosterone enanthate therapy study.”
Method
Testosterone Replacement Treatment Options for HIV-Infected Men
Cofrancesco, J., Whalen, J. J., & Dobs, A. S. (1997) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199712010-00006 · Cited by 34
The Dose-Dependent Effects of Testosterone on Sexual Function and on Muscle Mass and Function
Bhasin, S. (2000) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(19)30647-0 · Cited by 34
Effects of Heat Stress-Induced Sex Hormone Dysregulation on Reproduction and Growth in Male Adolescents and Beneficial Foods
Ko, S. (2024) · Nutrients · doi:10.3390/nu16173032 · Cited by 34
“Katznelson et al. have previously reported in a study of healthy, hypogonadal men with low serum testosterone levels that they had lower LBM and higher fat mass compared to age-matched eugonadal men [93].”
Result
Androgens: Basic Biology and Clinical Implication
ORWOLL, E. S. (2001) · Calcified Tissue International · doi:10.1007/s00223-001-1062-6 · Cited by 33
Human chorionic gonadotropin therapy in adolescent boys with constitutional delayed puberty vs those with β-thalassemia major
Soliman, A. T., Nasr, I. S., Thabet, M., Rizk, M. M., & El‐Matary, W. (2004) · Metabolism · doi:10.1016/j.metabol.2004.07.006 · Cited by 34
“In addition, studies have suggested that androgens have many other important physiological actions, including effects on sexual function, muscle, body composition, bone, bone marrow, prostate, and the central nervous system [42,50-53].”
Background
Androgen effects on body composition and muscle function: Implications for the use of androgens as anabolic agents in sarcopenic states
Bross, R., Casaburi, R. H., Storer, T. W., & Bhasin, S. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80077-3 · Cited by 33
Clomiphene citrate and enclomiphene for the treatment of hypogonadal androgen deficiency
Kaminetsky, J. C., & Hemani, M. L. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903405608 · Cited by 33
“With respect to longer-term aspects of androgen deficiency, testosterone was shown to increase bone density and lean body mass in 29 hypogonadal men aged 22 – 68 treated with testosterone enanthate [27].”
Background
Male hormones and men's quality of life
Khera, M. (2016) · Current Opinion in Urology · doi:10.1097/mou.0000000000000256 · Cited by 33
“Testosterone deficiency has been shown to result in changes in bone mineral density (BMD) [1,2], muscle strength [3,4], cognition [5], body composition [6], and sexual function [7].”
Background
Ellagic acid protects ovariectomy‐induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption
Lin, X., Yuan, G., Li, Z., Zhou, M., Hu, X., Song, F., Shao, S., Fu, F., Zhao, J., Xu, J., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29520 · Cited by 33
“The upsurge of the number or activity of osteoclasts leads to an imbalance between bone formation and bone resorption, which enhances the rate of osteoporosis‐ related fracture (Katznelson et al., 1996).”
Background
LUTEINIZING HORMONE-RELEASING HORMONE AGONIST EFFECTS ON SKELETAL MUSCLE: HOW HORMONAL THERAPY IN PROSTATE CANCER AFFECTS MUSCULAR STRENGTH
Williams, M. B., Hernández, J., & Thompson, I. M. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000143193.81585.5c · Cited by 32
Treatment of hypogonadism in men with chronic kidney disease
Johansen, K. L. (2004) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2004.07.006 · Cited by 31
The Male Contraceptive Regimen of Testosterone and Levonorgestrel Significantly Increases Lean Mass in Healthy Young Men in 4 Weeks, but Attenuates a Decrease in Fat Mass Induced by Testosterone Alone
Herbst, K. L., Anawalt, B. D., Amory, J. K., Matsumoto, A. M., & Bremner, W. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020918 · Cited by 32
Bariatric Surgery in Hypothalamic Obesity
Bingham, N. C., Rose, S. R., & Inge, T. H. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00023 · Cited by 32
“Testosterone replacement, in hypogonadal men has been shown to have beneficial effects on body composition, blood pressure, and glucose homeostasis (Katznelson et al., 1996; Boyanov et al., 2003; Wittert et al., 2003).”
Background
Androgen Inhibits Abdominal Fat Accumulation and Negatively Regulates the PCK1 Gene in Male Chickens
Duan, J., Shao, F., Yonggang, S., Li, J., Ling, Y., Teng, K., Li, H., & Wu, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059636 · Cited by 31
Causes of Secondary Osteoporosis
Orlić, Ž. C., & Raisz, L. G. (1999) · Journal of Clinical Densitometry · doi:10.1385/jcd:2:1:79 · Cited by 30
Testosterone enhances calcium reabsorption by the kidney
Couchourel, D., Leclerc, M., Filep, J. G., & Brunette, M. G. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.05.001 · Cited by 32
Testosterone Release From a Subcutaneous, Biodegradable Microcapsule Formulation (Viatrel) in Hypogonadal Men
Amory, J. K., Anawalt, B., Blaskovich, P. D., Gilchriest, J., Nuwayser, E. S., & Matsumoto, A. M. (2002) · Journal of Andrology · doi:10.1002/jand.2002.23.1.84 · Cited by 30
Progressive Improvement ofT-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
Haider, A., Meergans, U., Traish, A. M., Saad, F., Doros, G. D., Lips, P. T. A. M., & Gooren, L. J. (2014) · International Journal of Endocrinology · doi:10.1155/2014/496948 · Cited by 32
Testosterone Delivered with a Scaffold Is as Effective as Bone Morphologic Protein-2 in Promoting the Repair of Critical-Size Segmental Defect of Femoral Bone in Mice
Cheng, B.-H., Chu, T. G., Chang, C., Kang, H., & Huang, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070234 · Cited by 30
Androgen replacement therapy in the aging male.
Myers, J. B., & Meacham, R. B. (2003) · Europe PMC (PubMed Central) · Cited by 30
Bone mineral density outcomes following long‐term treatment with subcutaneous testosterone pellet implants in male hypogonadism
Zacharin, M., Pua, J., & Kanumakala, S. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01746.x · Cited by 30
Osteoporosis and osteoporotic fractures in men: a clinical perspective
Vanderschueren, D., Boonen, S., & Bouillon, R. (2000) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2000.0075 · Cited by 30
Osteoporosis
Stock, H., Schneider, A. E., & Strauss, E. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000136842.75487.e2 · Cited by 29
“Testosterone replacement therapy has been shown to reduce bone remodeling and increase trabecular BMD in these patients.(23) Although men experience a gradual decrease in testosterone levels with age, testosterone replacement therapy has only been shown to improve bone mass in patients with notable hypogonadism (testo…”
Background
Androgens and bone density in women with hypopituitarism.
Miller, K. K., Biller, B. M. K., Hier, J., Arena, E., & Klibanski, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8557 · Cited by 31
Self-citation
Assessment of Sex Differences in Body Composition Among Adolescents With Anorexia Nervosa
Nagata, J. M., Golden, N. H., Peebles, R., Long, J., Murray, S. B., Leonard, M. B., & Carlson, J. L. (2017) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2016.11.005 · Cited by 29
“muscle mass and studies in hypogonadal adults have demonstrated an increase in LM after testosterone replacement [32,33].”
Background
Pubertal induction in adolescents with DMD is associated with high satisfaction, gonadotropin release and increased muscle contractile surface area
Wood, C. L., Hollingsworth, K. G., Hughes, E., Punniyakodi, S., Muni‐Lofra, R., Mayhew, A. G., Mitchell, R. T., Guglieri, M., Cheetham, T. D., & Straub, V. W. (2020) · European Journal of Endocrinology · doi:10.1530/eje-20-0709 · Cited by 29
“Androgen deficiency is a risk factor for osteoporosis 241 and fracture and early initiation of androgen therapy is associated with improved bone 242 mineral density (29).”
Background
Testosterone replacement in men
Beg, S., Al-Khoury, L., & Cunningham, G. R. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328305081a · Cited by 29
Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle
Ye, F., McCoy, S. C., Ross, H. H., Bernardo, J. A., Beharry, A. W., Judge, S. M., Judge, A. R., Beck, D. T., Conover, C. F., Cannady, D. F., et al. (2014) · Steroids · doi:10.1016/j.steroids.2014.05.024 · Cited by 29
“may contribute to reduced muscle strength in men [4].”
Changes in calf muscle elasticity in hypogonadal males before and after testosterone substitution as monitored by magnetic resonance elastography
Brauck, K., Galbán, C. J., Maderwald, S., Herrmann, B. L., & Ladd, M. E. (2007) · European Journal of Endocrinology · doi:10.1530/eje-06-0694 · Cited by 29
Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism.
Christiansen, J., Gravholt, C., Fisker, S., Møller, N., Andersen, M., Svenstrup, B., Bennett, P., Ivarsen, P., Christiansen, J., & Jørgensen, J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01810 · Cited by 31
“In hypoandrogenic men, body fat is increased ( 35 ) and, during long-term androgen replacement, muscle protein synthesis (36) and muscle mass increase concomitantly with a reduction in body fat (35).”
Background
Hormone replacement in the aging male?☆
Hermann, M., & Berger, P. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00069-8 · Cited by 29
Testosterone stimulates extra‐hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men
Birzniece, V., Meinhardt, U. J., Handelsman, D. J., & Ho, K. K. Y. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03524.x · Cited by 27
The role of androgens or growth factors in the bone resorption process in recent spinal cord injured patients: a cross-sectional study
Maı̈moun, L., Lumbroso, S., Paris, F., Couret, I., Péruchon, E., Rouays-Mabit, E., Rossi, M., Leroux, J. L., & Sultan, C. (2006) · Spinal Cord · doi:10.1038/sj.sc.3101922 · Cited by 28
Androgen Replacement in Aging Men
Francis, R. M. (2001) · Calcified Tissue International · doi:10.1007/s00223-001-1051-9 · Cited by 28
“Another study compared bone composition measurements and bone density in 36 men aged 22–69 years with hypogonadism and 44 age-matched eugonadal control subjects [16].”
Background
Can Androgen Therapy Replete Lean Body Mass and Improve Muscle Function in Wasting Associated With Human Immunodeficiency Virus Infection?
Bhasin, S., & Javanbakht, M. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300605 · Cited by 28
Differential effects of diminished oestrogen and androgen levels on development of skeletal muscle fibres in hypogonadal mice
Sciote, J. J., Horton, M. J., Zyman, Y., & Pascoe, G. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00854.x · Cited by 27
Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans
Tchernof, A., Brochu, D., Maltais‐Payette, I., Mansour, M. F., Marchand, G. B., Carreau, A., & Kapeluto, J. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00043.x · Cited by 27
“No changes in weight were reported in nine studies (71, 143, 150, 187, 221, 227, 247, 296, 319) and weight gain was observed in six (23, 41, 189, 297, 298, 312).”
Influential
Effects of testosterone treatment on body composition in males with testosterone deficiency syndrome
Tolrà, J. R., Barreda, J. T., del Río, L., Gregorio, S. D., & Miranda, E. F. (2013) · The Aging Male · doi:10.3109/13685538.2013.839648 · Cited by 27
“Changes in body composition have been widely found in primary and secondary hypogonadism, with changes that reverse upon treatment with testosterone: patients tend to regain lean mass and lose fat mass [7].”
Background
The Novel Non-steroidal Selective Androgen Receptor Modulator S-101479 Has Additive Effects with Bisphosphonate, Selective Estrogen Receptor Modulator, and Parathyroid Hormone on the Bones of Osteoporotic Female Rats
Furuya, K., Yamamoto, N., Ohyabu, Y., Makino, A., Morikyu, T., Ishige, H., Kuzutani, K., & Endo, Y. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00054 · Cited by 27
Effects of risedronate in a rat model of osteopenia due to orchidectomy and disuse: Densitometric, histomorphometric and microtomographic studies
Libouban, H., Blouin, S., Moreau, M.-F., Baslé, M. F., Audran, M., & Chappard, D. (2007) · Micron · doi:10.1016/j.micron.2007.09.006 · Cited by 28
Polycystic Ovary Syndrome, Androgen Excess, And The Impact On Bone
Zborowski, J. V., Talbott, E. O., & Cauley, J. A. (2001) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70190-x · Cited by 27
Degree of fatness after treatment of malignant lymphoma in childhood
Nysom, K., Holm, K., Michaelsen, K. F., HERTZ, H., Müller, J., & Mølgaard, C. (2003) · Medical and Pediatric Oncology · doi:10.1002/mpo.10260 · Cited by 26
Long-term DHEA substitution in female adrenocortical failure, body composition, muscle function, and bone metabolism: a randomized trial
Christiansen, J. J., Bruun, J. M., Christiansen, J. S., Jørgensen, J. O., & Gravholt, C. H. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0289 · Cited by 26
Androgen receptor stimulates bone sialoprotein (BSP) gene transcription via cAMP response element and activator protein 1/glucocorticoid response elements
Takai, H., Nakayama, Y., Kim, D., Arai, M., Araki, S., Mezawa, M., Nakajima, Y., Kato, N., Masunaga, H., & Ogata, Y. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21297 · Cited by 26
“…effects of androgens on bone metabolism are well appreciated [Baran et al., 1978; Finkelstein et al., 1992; Ongphiphadhanakul et al., 1995; Katznelson et al., 1996; Anderson 2007 Wiley-Liss, Inc. University School of Dentistry at Matsudo; Grant sponsor: MEXT and Matching Fund Subsidy for…”
Background
Changes in Body Composition During Hormonal Therapy for Prostate Cancer
Smith, M. R. (2003) · Clinical Prostate Cancer · doi:10.3816/cgc.2003.n.008 · Cited by 26
Bone Marker and Bone Density Responses to Dopamine Agonist Therapy in Hyperprolactinemic Males
Di Somma, C. (1998) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.807 · Cited by 117
Current and future treatments of secondary osteoporosis
Soriano, R., Herrera, S., Nogués, X., & Díez‐Pérez, A. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.09.004 · Cited by 26
“Testosterone in adult menwith acquired [5] and idiopathic [6] hypogonadism induces significant increases in bone mineral density (BMD) and decreased bone remodelling.”
Advances in male hormone substitution therapy
Qoubaitary, A., Swerdloff, R. S., & Wang, C. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.9.1493 · Cited by 25
“Androgens administered as sublingual tablets, injections and transdermal preparations increased muscle mass assessed by dual-energy X-ray absorptiometry (DEXA) scans in hypogonadal men [72-75].”
BackgroundMethod
Percentage extremity fat, but not percentage trunk fat, is lower in adolescent boys with anorexia nervosa than in healthy adolescents
Misra, M., Katzman, D. K., Cord, J., Manning, S. J., Mickley, D. W., Herzog, D. B., Miller, K. K., & Klibanski, A. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26273 · Cited by 25
“In addition to an increase in lean mass (8–10), testosterone and GH cause a decrease in fat mass, particularly trunk fat (8, 11, 12).”
Self-citation
[Thyrotropin releasing hormone and serum levels of catecholamines as well as 11-hydroxycorticoids].
Brisse, B., Wagner, H., Vosberg, H., Hurbesch, M., Böckel, K., & Hauss, W. H. (1971) · PubMed · Cited by 25
Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism
Holland, A. M., Roberts, M. D., Mumford, P. W., Mobley, C. B., Kephart, W. C., Conover, C. F., Beggs, L. A., Balaez, A., Otzel, D. M., Yarrow, J. F., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00238.2016 · Cited by 24
“Interestingly, testosterone administration is known to improve subcutaneous and visceral adiposity and the associated morbidities known as metabolic syndrome (7, 9, 15, 18, 19, 28, 42, 55, 57, 58), exerting its effects on fat directly via AR binding and indirectly after tissue-specific aromatase enzyme conversion of t…”
Background
The effects of opioids on the endocrine system: an overview
Ali, K., Raphael, J. H., Khan, S., Labib, M. H., & Duarte, R. V. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2016-134299 · Cited by 24
“Further benefits may include an increase in muscle mass as well as stabilisation of other endocrine functions.[31,32] In addition to physical and biomechanical benefits of TRT, a recent study reported a significant improvement in mood amongst opioid users after TRT.”
Background
The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies
Nikolaou, N., Hodson, L., & Tomlinson, J. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105808 · Cited by 26
Role of sex steroids hormones in the regulation of bone metabolism in men: Evidence from clinical studies
Szulc, P. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101624 · Cited by 26
“They have lower aBMD and higher BTM levels (mainly bone resorption), but data are inconsistent (11,67,73,122).”
Andropause or Male Menopause? Rationale for Testosterone Replacement Therapy in Older Men with Low Testosterone Levels
Cunningham, G. R. (2013) · Endocrine Practice · doi:10.4158/ep13217.ra · Cited by 24
Sex and sex steroids: impact on the kinetics of fatty acids underlying body shape
Santosa, S., & Jensen, M. D. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0029 · Cited by 24
“Some investigators have reported reductions in upper body SAT [46, 50, 51, 53, 55], whereas others showed decreases in VAT [45, 49].”
Bone mineral density, structure, distribution and strength in men with prostate cancer treated with androgen deprivation therapy
Via, J. D., Daly, R. M., Owen, P. J., Mundell, N. L., Rantalainen, T., & Fraser, S. F. (2019) · Bone · doi:10.1016/j.bone.2019.06.005 · Cited by 25

Authors: Katznelson, L., Finkelstein, J. S., Schoenfeld, D. A., Rosenthal, D. I., Anderson, E. J., & Klibanski, A.
Affiliations: Massachusetts General Hospital (US)
ORCID: Katznelson, L
Finkelstein, J S
Schoenfeld, D A
Rosenthal, D I
Anderson, E J
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1996-12
Volume: 81
Issue: 12
Pages: 4358-4365
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.81.12.8954042
OpenAlex: W1974568933
Semantic Scholar: 829db808d1847d263af6c33d3397743284ea9f83
Cited by: 791
References: 38
Citations by year: 2026: 2 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 16 · 2021: 15 · 2020: 15 · 2019: 14 · 2018: 17 · 2017: 18 · 2016: 22 · 2015: 24 · 2014: 17 · 2013: 29 · 2012: 35
FWCI: 19.42
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5f32dk008738-02)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-08738)
National Center for Research Resources (RR 01066, M01RR001066)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: testosterone replacement therapy, testosterone enanthate, bone mineral density, trabecular bone density, lean body mass, body composition, fat mass, central hypogonadism, hypergonadotropic hypogonadism, bone-specific alkaline phosphatase, urinary deoxypyridinoline, bone turnover markers, men's health, osteoporosis prevention
MeSH terms: Adult, Aged, Body Composition, Bone Development, Humans, Hypogonadism, Cholesterol, HDL, Longitudinal Studies, Male, Middle Aged, Parathyroid Hormone, Growth Hormone, Testosterone, Bone Density

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks