Androgens, Obesity, and Sleep-Disordered Breathing in Men
Abstract
Impaired gonadal function, obesity, metabolic syndrome, and obstructive sleep apnea commonly occur together in men. We propose that this arises due to two interlinked cycles. Understanding the molecular mechanisms by which these relationships occur may lead to novel therapeutic strategies. Although obesity is not gender specific and the effectiveness of current antiobesity interventions have predominantly been verified in women, promoting weight loss in men is an urgent concern because men are have proportionally worse health consequences. In addition, avoiding excessive weight may maintain optimal male reproductive health.
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Low testosterone concentrations, OSA and obesity frequently occur together.
“low testosterone concentrations, OSA and obesity are known to frequently occur together”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [103]
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Self-citationSleep Apnea in Hemodialysis Patients: The Lack of Testosterone Effect on Its Pathogenesis
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Self-citationInsulin Action, Regional Fat, and Myocyte Lipid: Altered Relationships with Increased Adiposity
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Metabolic Aspects of Sleep Apnea
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Nandrolone, a 19-nortestosterone, enhances insulin-independent glucose uptake in normal men.
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Self-citationA Twin Study of Erectile Dysfunction
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OBSTRUCTIVE SLEEP APNEA INDUCED BY TESTOSTERONE ADMINISTRATION
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Flagged first, then by citations
5 of the 140 references couldn’t be matched to a known paper.
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The Hypoxic Testicle: Physiology and Pathophysiology
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Self-citationVaricoceles: prevalence and pathogenesis in adult men
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Self-citationSleep, testosterone and cortisol balance, and ageing men
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“Accordingly, low testosterone concentrations, OSA and obesity are known to frequently occur together, but the mechanisms that underpin these inter-relationships are not well established [103].”
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Self-citationEffect of normobaric hypoxia on the testis in a murine model
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Transcription regulation of NRF1 on StAR reduces testosterone synthesis in hypoxemic murine
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Testicular Dysfunction in Systemic Diseases
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Self-citationPoor Sleep Quality is an Independent Risk Factor for Acquired Premature Ejaculation
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Androgen therapy in non-gonadal disease
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Self-citationWindows of opportunity: a holistic approach to men's health*
Holden, C. A., Allan, C. A., & McLachlan, R. I. (2010) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2010.tb03708.x · Cited by 8 · see citing works
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Hypogonadismus und infertilität bei systemischen Erkrankungen
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Self-citationHypogonadism in Systemic Diseases
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Sleep apnea—Past, present, future
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Self-citationHypogonadism in Systemic Diseases
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Testicular Dysfunction in Systemic Diseases
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Self-citationThe putative mechanisms underlying testosterone and cardiovascular risk
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The putative mechanisms underlying testosterone and cardiovascular risk
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Androgen Replacement Therapy in Hypogonadal Men
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Relationship between obesity with symptoms and findings of obstructive sleep apnea syndrome
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Pathophysiology and Incidence of Varicocoeles in Men : what an Infertility Specialist Should Know
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Hypogonadismus, Infertilität und sexuelle Dysfunktion bei systemischen Erkrankungen
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Self-citationHypogonadismus, Infertilität und sexuelle Dysfunktion bei systemischen Erkrankungen
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Self-citationSleep, Circadian Rhythms, and Male Reproduction
Liu, P. Y. (2026) · Endocrinology · doi:10.1007/978-3-319-29456-8_64-1
Self-citationSex-specific omics scores of sex hormones and associations with metabolic and sleep disordersPreprint
Wang, Z., Zhang, Y., Wood, A. C., Benson, M. D., Taylor, K. D., Guo, X., Rich, S. S., Gerszten, R. E., Redline, S. S., Rotter, J. I., et al. (2026) · medRxiv · doi:10.64898/2026.04.27.26351843
Self-citation
- Authors
- Liu, P. Y., Caterson, I. D., Grunstein, R. R., & Handelsman, D. J.
- Affiliations
- The University of Sydney (AU)
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 36
- Issue
- 2
- Pages
- 349-363
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W2055223194
- Cited by
- 43
- References
- 140
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 7
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgens, obesity, sleep-disordered breathing, obstructive sleep apnea, metabolic syndrome, male reproductive health, weight loss, men
- MeSH terms
- Androgens, Humans, Male, Models, Biological, Obesity, Reproduction, Sleep Apnea, Obstructive, Metabolic Syndrome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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