The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina and endometrium in postmenopausal women.
Abstract
The effect of 12-month dehydroepiandrosterone (DHEA) replacement therapy has been evaluated in 14 60- to 70-yr-old women who received daily applications of a 10% DHEA cream. Vaginal epithelium maturation was stimulated by DHEA administration in 8 of 10 women who had a maturation value of zero at the onset of therapy, whereas a stimulatory effect was also seen in all three women who had an intermediate vaginal maturation index before therapy. The estrogenic effect of DHEA observed in the vagina was not observed in the endometrium, which remained atrophic in all women. Most interesting, the bone mineral density significantly increased at the hip from 0.744 +/- 0.021 to 0.759 +/- 0.025 g/cm2 after 12 months of treatment (P < 0.05). These changes in bone mineral density were associated with a significant 20.0% decrease (P < 0.01) in plasma bone alkaline phosphatase and a 28% decrease in the urinary hydroxyproline/creatinine ratio. A 2.1-fold increase over the control value (P < 0.01) in plasma osteocalcin was concomitantly observed. The present data describe for the first time a series of medically important beneficial effects of DHEA therapy in postmenopausal women through transformation of the precursor steroid DHEA into androgens and/or estrogens in specific peripheral intracrine tissues without significant adverse effects. The stimulatory effect on the vaginal epithelium in the absence of stimulation of the endometrium is of particular interest because it eliminates the need for progestin replacement therapy. On the other hand, the stimulatory effect on bone mineral density accompanied by an increase in serum osteocalcin, a marker of bone formation, suggests stimulation of bone formation by the androgenic action of DHEA, a finding of particular interest for both the prevention and treatment of osteoporosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“second, other studies of DHEA therapy in postmenopausal women (9) or aging (40,47) have also shown selective improvement in BMD at this site.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [9]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“positive effects of DHEA replacement have been described on psychological well-being (6), body composition (7,8), and bone mineral density (BMD) (9) in older, normal adults.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [9]
In the citing paper
“the absence of a stimulatory effect of DHEA on the human endometrium (73, 280) eliminates the need to administer a progestin to neutralize the stimulatory effect of estrogens in this tissue.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
In the citing paper
“Bone mass density was increased by 2.3% at the hip, 3.75% at the hip Ward's triangle, and 2.2% at the lumbar spine level (all P Ͻ 0.05; Ref. 280).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
In the citing paper
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
In the citing paper
“the estrogenic stimulatory effect observed in the vagina was not found in the endometrium, which remained completely atrophic in all women after 12 months of DHEA treatment (280).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
In the citing paper
“We have also determined that the serum levels of DHEA using a 10% cream (280) were comparable to the ones obtained after daily oral administration of 100 mg of DHEA (our unpublished data).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women.
Colditz, G. A., Hankinson, S. E., Hunter, D. J., Willett, W. C., Manson, J. E., Stampfer, M. J., Hennekens, C., Rosner, B., & Speizer, F. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506153322401 · Cited by 1,487
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841
Determination of serum creatinine by a direct colorimetric method
Heinegård, D. K., & Tiderström, G. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90466-x · Cited by 724
Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713
Self-citationA prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease.
Barrett-Connor, E., Khaw, K.-T., & Yen, S. S. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612113152405 · Cited by 681
The Functions of Corticosteroid-Binding Globulin and Sex Hormone-Binding Globulin: Recent Advances*
Rosner, W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-1-80 · Cited by 560
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553
Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality
Davis, S. R., McCloud, P., Strauss, B. J., & Burger, H. (1995) · Maturitas · doi:10.1016/0378-5122(94)00898-h · Cited by 534
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 291
Roshan, Nader, & Orlander (1999) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1999.00436.x · Cited by 51
Filaire, E., Duch�, P., & Lac, G. (1998) · European Journal of Applied Physiology · doi:10.1007/s004210050447 · Cited by 48
Straub, R. H., Schölmerich, J., & Zietz, B. (2000) · Zeitschrift für Rheumatologie · doi:10.1007/pl00022854 · Cited by 47
Sánchez‐Guerrero, J., Fragoso-Loyo, H. E., Neuwelt, C. M., Wallace, D. J., Ginzler, E. M., Sherrer, Y., McIlwain, H. H., Freeman, P. G., Aranow, C. B., Petri, M., et al. (2005) · PubMed · Cited by 47
Continuing Medical Education: Vulvovaginal Atrophy: Current and Future Therapies (CME)
Ibe, C. N., & Simon, J. A. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01692.x · Cited by 46
The role of estrogens in men and androgens in women
Khosla, S., & Bilezikian, J. P. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(02)00087-7 · Cited by 43
Hormone Replacement Therapy and Fractures in Older Adults
Kamel, H. K., Perry, H. M., & Morley, J. E. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49040.x · Cited by 44
The effect of circulating androgens on bone mineral density in postmenopausal women.
Tok, E. C., Ertunc, D., Oz, U., Camdeviren, H., Ozdemir, G., & Dilek, S. (2004) · Maturitas · doi:10.1016/j.maturitas.2003.11.007 · Cited by 44
Dehydroepiandrosterone Supplementation and Bone Turnover in Middle-Aged to Elderly Men
Kahn, A., & Halloran, B. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8396 · Cited by 44
Stomati, M., Rubino, S., Spinetti, A., Parrini, D., Luisi, S. V., Casarosa, E., Petraglia, F., & Genazzani, A. R. (1999) · Gynecological Endocrinology · doi:10.1080/09513599909167527 · Cited by 41
Labrie, F., Cusan, L., Gomez, J., Martel, C., Bérubé, R., Bélanger, P., Chaussade, V., Deloche, C., & Leclaire, J. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.02.003 · Cited by 39
Self-citationBloch, M., Ish‐Shalom, S., Greenman, Y., Klein, E., & Latzer, Y. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.012 · Cited by 41
Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat.
Sourla, A., Flamand, M., Bélanger, A., & Labrie, F. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00052-1 · Cited by 40
Self-citationThe Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers
Rižner, T. L., Thalhammer, T., & Özvegy‐Laczka, C. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00346 · Cited by 41
Rice, S., Agarwal, N., Bolusani, H., Newcombe, R. G., Scanlon, M. F., Ludgate, M., & Rees, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2636 · Cited by 40
Osteoporosis and breast cancer
Fontanges, É., Fontana, A., & Delmas, P. D. (2003) · Joint Bone Spine · doi:10.1016/j.jbspin.2003.02.001 · Cited by 40
The Role of Sex Steroid Hormones in Female Sexual Function and Dysfunction
Goldstein, I., TRAISH, A. M., Kim, N. N., & Munarriz, R. M. (2004) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-200406000-00022 · Cited by 41
High internal consistency and efficacy of intravaginal DHEA for vaginal atrophy
Labrie, F., Archer, D. F., Bouchard, C., Fortier, M. P., Cusan, L., Gomez, J., Girard, G., Baron, M., Ayotte, N. J., Moreau, M., et al. (2010) · Gynecological Endocrinology · doi:10.3109/09513590903511547 · Cited by 39
Self-citationPangenomic changes induced by DHEA in the skin of postmenopausal women
Calvo, E. L., Luu-The, V., Morissette, J., Martel, C., Labrie, C., Bernard, B., Bernerd, F., Deloche, C., Chaussade, V., Leclaire, J., et al. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.10.008 · Cited by 42
Self-citationDehydroepiandrosterone, androgens and the mammary gland
Labrie, F. (2006) · Gynecological Endocrinology · doi:10.1080/09513590600624440 · Cited by 39
Self-citationTaylor, M. K., Padilla, G. A., Stanfill, K. E., Markham, A. E., Khosravi, J. Y., Dial Ward, M. D., & Koehler, M. M. (2012) · Stress · doi:10.3109/10253890.2011.585189 · Cited by 38
Couillard, S., Labrie, C., Bélanger, A., Candas, B., Pouliot, F., & Labrie, F. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.10.772 · Cited by 38
Self-citationWang, L., Wang, Y.-D., Wang, W.-J., & Li, D.-J. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0631-1 · Cited by 37
Labrie, F., Archer, D. F., Bouchard, C., Fortier, M. P., Cusan, L., Gomez, J., Girard, G., Baron, M., Ayotte, N., Moreau, M., et al. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12517 · Cited by 38
Self-citationAROMATASE IN PRIMATE PREGNANCY: A REVIEW
Kragie, L. (2002) · Endocrine Research · doi:10.1081/erc-120015041 · Cited by 38
Labrie, F., Bèlanger, A., Labrie, C., Candas, B., Cusan, L., & Gomez, J.-L. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.02.007 · Cited by 36
Self-citationDHEA and the Skeleton (Through the Ages)
Gordon, C. M., Glowacki, J., & LeBoff, M. S. (1999) · Endocrine · doi:10.1385/endo:11:1:1 · Cited by 37
DEHYDROEPIANDROSTERONE IN SYSTEMIC LUPUS ERYTHEMATOSUS
van Vollenhoven, R. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70142-3 · Cited by 36
Is there a case for DHEA replacement?
Nippoldt, T. B., & Nair, K. S. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80286-3 · Cited by 36
Davis, S. R. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb127881.x · Cited by 36
Kumar, P., Taha, A., Sharma, D., Kale, R. K., & Baquer, N. Z. (2008) · Biogerontology · doi:10.1007/s10522-008-9133-y · Cited by 35
Yu, F., Yang, Y., Lei, L., Chen, Liu, Chen, & Liu (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00484.x · Cited by 35
Dehydroepiandrosterone inhibited the bone resorption through the upregulation of OPG/RANKL.
Wang, Y. D., Wang, L., Li, D. J., & Wang, W. J. (2006) · PubMed · Cited by 33
Dehydroepiandrosterone for Adrenal Insufficiency
Oelkers, W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411409 · Cited by 32
Fokidis, H. B., Adomat, H. H., Kharmate, G., Beheshti, E. H., Guns, E. S. T., & Soma, K. K. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.08.005 · Cited by 31
Gordon, C. M., Binello, E., LeBoff, M. S., Wohl, M. E. B., Rosen, C. J., & Colin, A. A. (2006) · Osteoporosis International · doi:10.1007/s00198-005-0058-x · Cited by 31
Replacement therapy for Addison's disease: recent developments
Løvås, K., & Husebye, E. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.4.497 · Cited by 33
The Dehydroepiandrosterone And WellNess (DAWN) study: Research design and methods
von Mühlen, D. G., Laughlin, G. A., Kritz‐Silverstein, D. C., & Barrett-Connor, E. L. (2006) · Contemporary Clinical Trials · doi:10.1016/j.cct.2006.04.009 · Cited by 32
Tummala, S., & Svec, F. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00021-1 · Cited by 33
Kanazawa, I., Yamaguchi, T., Yamamoto, M., Yamauchi, M., Kurioka, S., Yano, S., & Sugimoto, T. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-130 · Cited by 30
Nonestrogen Therapies for Treatment of Genitourinary Syndrome of Menopause
Evans, E. A. C., Hobson, D., Aschkenazi, S. O., Alas, A., Balgobin, S., Balk, E. M., Dieter, A. A., Kanter, G., Orejuela, F. J., Sanses, T. V. D., et al. (2023) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005288 · Cited by 29
Looby, S. E. D., Collins, M., Lee, H., & Grinspoon, S. K. (2009) · AIDS · doi:10.1097/qad.0b013e3283299145 · Cited by 30
Hartkamp, A., Geenen, R., Godaert, G. L. R., Bijl, M., Bijlsma, J. W. J., & Derksen, R. H. W. M. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20610 · Cited by 27
Acute Dehydroepiandrosterone Effects on Sexual Arousal in Premenopausal Women
Meston, C. M., & Heiman, J. R. (2002) · Journal of Sex & Marital Therapy · doi:10.1080/009262302317251016 · Cited by 28
Archer, D. F. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.09.003 · Cited by 27
Bentley, C., Hazeldine, J., Greig, C. A., Lord, J. M., & Foster, M. (2019) · Burns & Trauma · doi:10.1186/s41038-019-0158-z · Cited by 28
An update on the pharmacological management of female sexual dysfunction
Fooladi, E., & Davis, S. R. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.725046 · Cited by 26
Skin responses to topical dehydroepiandrosterone: implications in antiageing treatment?
Elalfy, M., Deloche, C., Azzi, L., Bernard, B. A., Bernerd, F., Coutet, J., Chaussade, V., Martel, C., Leclaire, J., & Labrie, F. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09972.x · Cited by 27
Self-citationDessein, P. H., Joffe, B. I., Stanwix, A. E., & Moomal, Z. (2001) · Arthritis Research & Therapy · doi:10.1186/ar296 · Cited by 26
Karavitakis, M., Komninos, C., Simaioforidis, V., Kontos, S., Lefakis, G., Politis, V., Koritsiadis, G., Konstantellou, K., & Doumanis, G. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01915.x · Cited by 24
High-performance liquid chromatographic analysis of dehydroepiandrosterone
Marwah, A. K., Marwah, P., & Lardy, H. A. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01268-7 · Cited by 24
Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females
Callies, F., Arlt, W., Siekmann, L., Hübler, D., BIDLINGMAIER, F., & Allolio, B. (2000) · Steroids · doi:10.1016/s0039-128x(99)00090-2 · Cited by 24
Androgen Deficiency in the Aging Male
Morales, Á., & Heaton, J. P. W. (2005) · Humana Press eBooks · doi:10.1385/1-59259-871-4:279 · Cited by 23
Progress and Prospects in Treating Postmenopausal Vaginal Atrophy
Winneker, R. C., & Harris, H. A. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.161 · Cited by 23
Kanazawa, I., Yamaguchi, T., & Sugimoto, T. (2011) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2011.07.004 · Cited by 23
Hampson, G., Bhargava, N., Cheung, J., Vaja, S., Seed, P. T., & Fogelman, I. (2002) · Metabolism · doi:10.1053/meta.2002.35583 · Cited by 22
Plaza, F., Gabler, F., Romero, C., Vantman, D., Valladares, L., & Vega, M. (2010) · Steroids · doi:10.1016/j.steroids.2010.06.011 · Cited by 22
Low Serum DHEAS Predicts Increased Fracture Risk in Older Men: The MrOS Sweden Study
Ohlsson, C., Nethander, M., Kindmark, A., Ljunggren, Ö., Lorentzon, M., Rosengren, B. E., Karlsson, M. K., Mellström, D., & Vandenput, L. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3123 · Cited by 22
Lardy, H. A., Marwah, A. K., & Marwah, P. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71009-8 · Cited by 22
Berger, L., Elalfy, M., & Labrie, F. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.023 · Cited by 21
Self-citationWhat is the Rationale for Androgen Therapy for Women?
Papalia, M.-A., & Davis, S. R. (2003) · Treatments in Endocrinology · doi:10.2165/00024677-200302020-00001 · Cited by 21
Ceresini, G., Morganti, S., Rebecchi, I., Freddi, M., Ceda, G. P., Banchini, A., Solerte, S. B., Ferrari, E., Ablondi, F., & Valenti, G. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80024-4 · Cited by 22
Therapeutic effects of progestins, androgens, and tibolone for menopausal symptoms
LIU, J. H. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.040 · Cited by 20
Harding, G., Mak, Y. T., Evans, B. A. J., Cheung, J., MacDonald, D., & Hampson, G. (2006) · Cytokine · doi:10.1016/j.cyto.2006.10.012 · Cited by 20
Yamada, Y., Sekihara, H., Omura, M., Yanase, T., Takayanagi, R., Mune, T., Yasuda, K., Ishizuka, T., Ueshiba, H., Miyachi, Y., et al. (2007) · Endocrine Journal · doi:10.1507/endocrj.k05-132 · Cited by 20
Bioavailability and Pharmacokinetics of Dehydroepiandrosterone in the Cynomolgus Monkey
Leblanc, M., Labrie, C., Bélanger, A., Candas, B., & Labrie, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-022012 · Cited by 20
Self-citationHeutling, D., & Lehnert, H. (2008) · Der Internist · doi:10.1007/s00108-008-2110-3 · Cited by 19
Stanczyk, F. Z., Slater, C. C., Ramos, D. E., Azen, C. G., Cherala, G., Hakala, C., Abraham, G. E., & Roy, S. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31818adb3f · Cited by 19
DHEA in bone and joint diseases
Cormier, C., Souberbielle, J., & Kahan, A. (2001) · Joint Bone Spine · doi:10.1016/s1297-319x(01)00327-x · Cited by 19
Bone metabolism and the perimenopause
Sayegh, R. A., & Stubblefield, P. G. (2002) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(02)00012-8 · Cited by 19
Ashida, K., Goto, K., Zhao, Y., Okabe, T., Yanase, T., Takayanagi, R., Nomura, M., & Nawata, H. (2005) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2005.01.016 · Cited by 18
Aimaretti, G., Baffoni, C., Ambrosio, M. R., Maccario, M., Corneli, G., Bellone, S., Gasperi, M., Uberti, E. C. D., & Ghigo, E. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343668 · Cited by 18
Optimizing bone health in anorexia nervosa and hypothalamic amenorrhea: new trials and tribulations
Foo, J., Hamnvik, O. R., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.003 · Cited by 17
Corrigan, B. (2002) · Clinical Journal of Sport Medicine · doi:10.1097/00042752-200207000-00006 · Cited by 17
Transformations of DHEA and its metabolites by rat liver
Lardy, H. A., Marwah, A. K., & Marwah, P. (2002) · Lipids · doi:10.1007/s11745-002-1019-7 · Cited by 17
DHEA as physiological replacement therapy at menopause
Labrie, F. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350777 · Cited by 17
Self-citationDehydroepiandrosterone to Enhance Physical Performance: Myth and Reality
Hahner, S., & Allolio, B. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.10.008 · Cited by 16
Kanazawa, I., Yamaguchi, T., & Sugimoto, T. (2012) · PubMed · doi:10.3275/8033 · Cited by 16
Kasap, B., Kasap, Ş., Vatansever, S., Kendirci, R., Yılmaz, O., Çalışır, M., Edgünlü, T., & Akın, M. N. (2019) · Gene · doi:10.1016/j.gene.2019.06.027 · Cited by 16
Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey
Leblanc, M., Labrie, C., Bélanger, A., Candas, B., & Labrie, F. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00059-6 · Cited by 16
Self-citationAndrogen Status in Healthy Premenopausal Women with Loss of Libido
Nyunt, A., Stephen, G., Gibbin, J., Durgan, L., Fielding, A., Wheeler, M., & Price, D. (2005) · Journal of Sex & Marital Therapy · doi:10.1080/00926230590475314 · Cited by 18
Effects of Dehydroepiandrosterone on Bone Mineral Density
Villareal, D. T. (2002) · Treatments in Endocrinology · doi:10.2165/00024677-200201060-00001 · Cited by 16
Wishing a dream came true: DHEA as a rejuvenating treatment?
Wolf, O. T., & Kirschbaum, C. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350328 · Cited by 16
The Use of Androgens in Menopause
Hoeger, K. M., & Guzick, D. S. (1999) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-199912000-00016 · Cited by 16
Li, X., Wu, K., Dong, Q., Chen, H., Li, C., Ren, Z., Liu, F., Yue, X., Xia, C., Wang, Y., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1074516 · Cited by 15
Consensus Document on substitution therapy with DHEA in the elderly
Valenti, G. (2006) · Aging Clinical and Experimental Research · doi:10.1007/bf03324662 · Cited by 14
Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism
Mauriège, P., Martel, C., Langin, D., Lacaille, M., Després, J., Bèlanger, A., Labrie, F., & Deshaies, Y. (2003) · Metabolism · doi:10.1053/meta.2003.50043 · Cited by 16
Self-citationPoretsky, L., Brillon, D. J., Ferrando, S. J., Chiu, J. A., McElhiney, M. C., Ferenczi, A., Sison, M. C. I. P., Haller, I., & Rabkin, J. G. (2006) · Metabolism · doi:10.1016/j.metabol.2006.02.013 · Cited by 15
Hormonal aspects of sexual dysfunction: The therapeutic use of exogenous androgens in men and women
Seidman, S. N. (2000) · Current Psychiatry Reports · doi:10.1007/s11920-996-0011-5 · Cited by 16
Androgens and bone: Clinical implications for menopausal women
Shoupe, D. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70730-1 · Cited by 15
Rabijewski, M., Papierska, L., Bińkowska, M., Maksym, R., Jankowska, K. K., Skrzypulec‐Plinta, V., & Zgliczyński, W. (2020) · Ginekologia Polska · doi:10.5603/gp.2020.0091 · Cited by 15
Hovi, L., Saarinen‐Pihkala, U. M., Taskinen, M. H., Wikström, A. M., & Dunkel, L. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704376 · Cited by 14
Wiren, K. M., & ORWOLL, E. S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374602-3.00025-0 · Cited by 14
Dehydroepiandrosterone Treatment in the Aging Male – What Should the Urologist Know?
Saad, F., Hoesl, C. E., Oettel, M., Fauteck, J., & Römmler, A. (2005) · European Urology · doi:10.1016/j.eururo.2005.06.020 · Cited by 14
Importance of dehydroepiandrosterone and dehydroepiandrosterone sulfate in different diseases
Bácsi, K., Kosa, J. P., Lazáry, Á., Horváth, H. C., Balla, B., Lakatos, P. L., & Speer, G. (2007) · Orvosi Hetilap · doi:10.1556/oh.2007.27903 · Cited by 13
LeBoff, M. S., & Glowacki, J. (1999) · Elsevier eBooks · doi:10.1016/b978-012098655-2/50017-x · Cited by 13
Vailati, S., Melloni, E., Riscassi, E., Behr‐Roussel, D., & Sardina, M. (2013) · Sexual Medicine · doi:10.1002/sm2.8 · Cited by 11
Lin, H., Li, L., Wang, Q., Wang, Y., Wang, J., & Long, X. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2019.1616175 · Cited by 11
Dehydroepiandrosterone replacement therapy
Arlt, W. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000224811.39318.73 · Cited by 11
Potential Anabolic Effects of Androgens on Bone
Kearns, A. E., & Khosla, S. (2004) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(19)30667-6 · Cited by 11
Metadata
- Authors
- Labrie, F., Diamond, P., Cusan, L., Gomez, J.-L., Bélanger, A., & Candas, B.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Labrie, Fernand
- ORCID
- Candas, Bernard
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-10
- Volume
- 82
- Issue
- 10
- Pages
- 3498-3505
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1970025509
- Cited by
- 292
- References
- 71
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 10
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- dehydroepiandrosterone, DHEA replacement therapy, postmenopausal women, bone mineral density, endometrial atrophy, osteocalcin, bone-specific alkaline phosphatase, urinary hydroxyproline, osteoporosis prevention, androgenic effects, estrogenic effects
- MeSH terms
- Aged, Atrophy, Bone and Bones, Bone Resorption, Dehydroepiandrosterone, Endometrium, Female, Humans, Middle Aged, Osteogenesis, Sebum, Sex Hormone-Binding Globulin, Vagina, Biomarkers, Bone Density, Bone Remodeling, Postmenopause
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
