The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging
Abstract
The present data show a dramatic decline in the circulating levels of dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEA-S), androst-5-ene-3β,17β-diol (5-diol), 5-diol-sulfate, 5-diol-fatty acid esters, and androstenedione in both men and women between the ages of 20–80 yr. In the 50- to 60-yr-old group, serum DHEA decreased by 74% and 70% from its peak values in 20- to 30-yr-old men and women, respectively. The serum concentrations of the conjugated metabolites of dihydrotestosterone (DHT), namely androsterone (ADT)-G, androstane-3α,17β-diol (3α-diol-G), androstane-3β,17β-diol (3β-diol-G), and ADT-sulfate are the most reliable parameters of the total androgen pool in both men and women, whereas serum testosterone and DHT can be used as markers of testicular secretion in men and interstitial ovarian secretion in women. The serum concentration of these various conjugated androgen metabolites decreased by 40.8% to 72.8% between the 20- to 30-yr-old and 70- to 80-yr-old age groups in men and women, respectively, thus suggesting a parallel decrease in the total androgen pool with age. As estimated by measurement of the circulating levels of these conjugated metabolites of DHT, it is noteworthy that women produce approximately 66% of the total androgens found in men. In women, most of these androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues, whereas in men the testes and DHEA and DHEA-S provide approximately equal amounts of androgens at the age of 50–60 yr. An additional potentially highly significant observation is that the majority of the marked decline in circulating adrenal C19 steroids and their resulting androgen metabolites takes place between the age groups of 20- to 30-yr olds and 50- to 60-yr-olds, with smaller changes are observed after the age of 60 yr.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Dihydroepiandrosterone sulphate is a precursor to testosterone, with concentrations that also decrease with ageing—in men aged 70–80 years, dihydroepiandrosterone sulphate concentrations are only about 20% of their peak concentrations at the age of 20 years.78”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [78]
In the citing paper
“in the 50-to 60-yr-old age group, serum DHEA has already decreased by 70%, compared with the 20-to 30-yr-old peak values (Ref.23; Fig. 1).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“Serum androgens as well as their precursors and metabolites decrease from the age of 30 -40 yr in women”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“As assessed by measurement of the circulating levels of these conjugated metabolites of DHT, it can be estimated that women produce approximately 71% or two thirds of the total androgens synthesized in men (Table 1);”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“an estimate of the relative amount of total androgens in women and men calculated on the basis of the sum of the serum concentrations of these three metabolites suggests that total androgen production in women is more than two thirds, or 71%, of that observed in men (23,27).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“the changes in precursor androgen secretion by the adrenals precede by 10 -20 yr the detectable decrease in ovarian steroidogenesis that occurs abruptly at menopause (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“in women, most of these androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“thus suggesting a parallel decrease in the total androgen pool with age (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“The serum concentration of the aboveindicated conjugated androgen metabolites decreases by 47.5-72.7% between the 20-to 30-and 70-to 80-yr age groups in women,”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“the pool of androgens in women decreases progressively from the age of 30 yr in parallel with the decrease in the serum concentration of DHEA and DHEA-S (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“The decline of testosterone and DHEA (23,26,321,322) with age could be at least partially responsible for sarcopenia in older men and women.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685
Self-citationChanges in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437
Self-citationNeuronal migration and contact guidance in the primate telencephalon.
RAKIC, P. T. (1978) · PubMed · Cited by 395
Vermeulen, A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-221 · Cited by 384
The, V. L., Lachance, Y., Labrie, C., Leblanc, G., Thomas, J. L., Strickler, R. C., & Labrie, F. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1310 · Cited by 309
Self-citationComplete androgen blockade for the treatment of prostate cancer.
Labrie, F., Dupont, A., & Bèlanger, A. (1985) · PubMed · Cited by 285
Self-citationDHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 709
Prevalence of dry eye disease in southern Egypt: a hospital-based outpatient clinic study
Mostafa, E. (2016) · Journal of the Egyptian Ophthalmological Society · doi:10.4103/2090-0686.192749 · Cited by 19
Krishnan, S., Gustafson, M. B., Campbell, C., Gaikwad, N. W., & Keim, N. L. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000198 · Cited by 19
Franco, M. R. H., Dewailly, D., Decanter, C., Knochenhauer, E. S., Boots, L. R., & Azziz, R. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00402-1 · Cited by 19
Wang, F., Koskela, A., Hämäläinen, E., Turpeinen, U., Savolainen-Peltonen, H., Mikkola, T. S., Vihma, V., Adlercreutz, H., & Tikkanen, M. J. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.01.014 · Cited by 18
Sex and Sex Hormones Mediate Wound Healing
Thomason, H. A., Williams, H., & Hardman, M. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-16438-0_2 · Cited by 18
Wu, S., Ye, M., Li, Z., Bu, S., & Zhang, Y. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05180 · Cited by 18
Aimaretti, G., Baffoni, C., Ambrosio, M. R., Maccario, M., Corneli, G., Bellone, S., Gasperi, M., Uberti, E. C. D., & Ghigo, E. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343668 · Cited by 18
Polymorphisms in the CYP19 Gene that Influence Bone Mineral Density
Riancho, J. A. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.4.339 · Cited by 18
Skeletal Changes in Transgenic Male Mice Expressing Human Cytochrome P450 Aromatase
Peng, Z., Li, X., Mäkelä, S., Väänänen, H. K., & POUTANEN, M. H. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040510 · Cited by 20
Labrie, F., & Martel, C. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0042 · Cited by 17
Self-citationChung, K.-F., Qin, N., Androutsellis‐Theotokis, A., Bornstein, S. R., & Ehrhart‐Bornstein, M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.028 · Cited by 17
Honců, P., Hill, M., Bičı́ková, M., Jandová, D., Velíková, M., Kajzar, J., Kolátorová, L., BEŠŤÁK, J., Máčová, L., Kancheva, R. L., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153687 · Cited by 17
Nuts and Metabolic Syndrome: Reducing the Burden of Metabolic Syndrome in Menopause
Bauset, C., Aspas, A. M., Smith-Ballester, S., García-Vigara, A., Monllor-Tormos, A., Kadi, F., Nilsson, A. E., & Cano, A. (2022) · Nutrients · doi:10.3390/nu14081677 · Cited by 17
Mitamura, K., Setaka, M., Shimada, K., Honma, S., Namiki, M., Koh, E., & Mizokami, A. (2005) · Biomedical Chromatography · doi:10.1002/bmc.522 · Cited by 17
Assessment of steroidogenic pathways that do not require testosterone as intermediate
Luu-The, V. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.007 · Cited by 18
ACE inhibitor use was associated with lower serum dehydroepiandrosterone concentrations in older men
Kwok, T. C. Y., Ohlsson, C., Vandenput, L., Tang, N. L. S., Zhang, Y. F., Tomlinson, B., & Leung, P. C. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.04.011 · Cited by 17
Development of cyclodextrin hydrogels for vaginal delivery of dehydroepiandrosterone
Mennini, N., Casella, G., Cirri, M., Maestrelli, F., & Mura, P. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12549 · Cited by 17
Is Reduced Cell Size the Mechanism for Shrinkage of the Adrenal Zona Reticularis in Aging?
Staton, B., Mixon, R. L., Dharia, S. P., Brissie, R. M., & Parker, C. R. (2004) · Endocrine Research · doi:10.1081/erc-200043617 · Cited by 17
DHEA as physiological replacement therapy at menopause
Labrie, F. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350777 · Cited by 17
Self-citationStem Cell-Derived Extracellular Vesicles in Skin Antiaging Treatments
Park, J. Y., Jung, S. Y., Yoo, D., Lee, S., Go, D., Bui, V. D., Jung, W., You, D. G., Park, J. H., & Um, W. (2025) · ACS Nano · doi:10.1021/acsnano.4c17406 · Cited by 18
Hydrohysteroid Dehydrogenases – Biological Role and Clinical Importance – Review
Atanassova, N. N., & Koev, Y. (2012) · InTech eBooks · doi:10.5772/54149 · Cited by 16
Circulating 5α-dihydrotestosterone, abdominal obesity and adipocyte characteristics in women
Côté, J. A., Lessard, J., Mailloux, J. R., Laberge, P. Y., Rhéaume, C., & Tchernof, A. (2012) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2012-0026 · Cited by 16
Reproductive System Outcome Among Patients with Polycystic Ovarian Syndrome
Carmina, E. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.07.006 · Cited by 16
Gundlach, N. H., Schmicke, M., Ludes‐Wehrmeister, E., Ulrich, S. A., Araujo, M. G., & Siebert, U. (2018) · Journal of Zoo and Wildlife Medicine · doi:10.1638/2017-0191.1 · Cited by 16
Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey
Leblanc, M., Labrie, C., Bélanger, A., Candas, B., & Labrie, F. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00059-6 · Cited by 16
Self-citationAdrenocortical responses to submaximal exercise in postmenopausal black and white women
Giannopoulou, I., Carhart, R. L., Sauro, L. M., & Kanaley, J. A. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00312-3 · Cited by 16
Hertoghe, T. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb06150.x · Cited by 16
Do intracrine mechanisms regulate aromatase expression?
Simpson, E. R., Jones, M. E. E., Davis, S. R., & Rubin, G. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00067-9 · Cited by 16
The Use of Androgens in Menopause
Hoeger, K. M., & Guzick, D. S. (1999) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-199912000-00016 · Cited by 16
Sirrs, S. M., & Bebb, R. A. (1999) · PubMed Central · Cited by 16
Chan, A. O.-K., Taylor, N., Tiu, S. C., & Shek, C. C. (2008) · Steroids · doi:10.1016/j.steroids.2008.03.004 · Cited by 15
Labrie, F. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649520.008 · Cited by 15
Self-citationHirshman, E., Wells, E. C., Wierman, M. E., Anderson, B., Butler, A., Senholzi, M., & Fisher, J. (2003) · Psychonomic Bulletin & Review · doi:10.3758/bf03196476 · Cited by 15
Rosa, V. L. L., Ciebiera, M., Lin, L., Fan, S., Butticè, S., Sathyapalan, T., Jędra, R., Lordêlo, P., & Favilli, A. (2019) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2019.86836 · Cited by 15
When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer
Lapeire, L., Denys, H. G., Cocquyt, V., & Wever, O. D. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0018 · Cited by 16
Managing Low Sexual Desire in Women
Maclaran, K., & Panay, N. (2011) · Women s Health · doi:10.2217/whe.11.54 · Cited by 15
Experimental Neurogenic Cystitis
Jasmin, L., & Janni, G. (2003) · Springer eBooks · doi:10.1007/978-1-4419-8889-8_24 · Cited by 15
Physiological Effects of Androgens in Women
Hodgson, T. K., & Braunstein, G. D. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-179-6_4 · Cited by 17
Hanoglu, S. B., Durmus, C., Celikbas, E., Gümüş, Z. P., & Timur, S. (2019) · Electroanalysis · doi:10.1002/elan.201900413 · Cited by 14
Consensus Document on substitution therapy with DHEA in the elderly
Valenti, G. (2006) · Aging Clinical and Experimental Research · doi:10.1007/bf03324662 · Cited by 14
Dehydroepiandrosterone and Pregnenolone Alterations in Schizophrenia
Ritsner, M. S., Gibel, A., Ratner, Y., & Weizman, A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6854-6_14 · Cited by 14
Symposium: conference on the science and policy of performance-enhancing products
Fomous, C., Costello, R. B., & Coates, P. M. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200210000-00022 · Cited by 14
Dehydroepiandrosterone Treatment in the Aging Male – What Should the Urologist Know?
Saad, F., Hoesl, C. E., Oettel, M., Fauteck, J., & Römmler, A. (2005) · European Urology · doi:10.1016/j.eururo.2005.06.020 · Cited by 14
Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model
Ethun, K. F., Wood, C. E., Parker, C. R., Kaplan, J. R., CHEN, H.-Y. P., & Appt, S. E. (2011) · Climacteric · doi:10.3109/13697137.2011.571321 · Cited by 14
Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men
Déchaud, H., Denuzière, A., Rinaldi, S., Bocquet, J., Lejeune, H., & PUGEAT, M. M. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.077362 · Cited by 14
Edes, A. N. (2017) · Primates · doi:10.1007/s10329-017-0602-2 · Cited by 14
Adrenal function under long-term raloxifene administration
GENAZZANI, A. R., Lombardi, I., Borgioli, G., di Bono, I., Casarosa, E., Gambacciani, M., Palumbo, M. A., Genazzani, A. D., & Luisi, M. (2003) · Gynecological Endocrinology · doi:10.1080/713603211 · Cited by 14
Importance of dehydroepiandrosterone and dehydroepiandrosterone sulfate in different diseases
Bácsi, K., Kosa, J. P., Lazáry, Á., Horváth, H. C., Balla, B., Lakatos, P. L., & Speer, G. (2007) · Orvosi Hetilap · doi:10.1556/oh.2007.27903 · Cited by 13
Phan, M. A. T., Gibson, E., Golebiowski, B., Stapleton, F. J., Jenner, A. M., & Bucknall, M. P. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109283 · Cited by 13
Increased vascular surface density in ovarian endometriosis
Inan, S., Kuşçu, N. K., Vatansever, S., Özbilgin, K., Koyuncu, F. M., & Sayhan, S. (2003) · Gynecological Endocrinology · doi:10.1080/713603221 · Cited by 13
Cavani, S., Tamaoka, A., Moretti, A., Marinelli, L., Angelini, G., Stefano, S. D., Piombo, G., Cazzulo, V., Matsuno, S., Shoji, S., et al. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20001127)95:3 · Cited by 33
Delayed wound healing in elderly people
Thomason, H. A., & Hardman, M. J. (2009) · Reviews in Clinical Gerontology · doi:10.1017/s095925980999027x · Cited by 14
Bazin, M., Travert, C., Carreau, S., Rault, S., & Kihel, L. E. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.02.036 · Cited by 13
Dehydroepiandrosterone sulfate and dehydroepiandrosterone: neuroactive neurosteroids
Akwa, Y., & Baulieu, É.-É. (2000) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200006000-00010 · Cited by 13
Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription
Chen, Y., Zhen, Z., Chen, L., Wang, H., Wang, X., Sun, X., Song, Z., Wang, H., Lin, Y., Zhang, W., et al. (2023) · EMBO Reports · doi:10.15252/embr.202356984 · Cited by 12
Gupte, R. S., Dhagia, V., Ročić, P., Ochi, R., & Gupte, S. A. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00727.2019 · Cited by 12
Cellular Senescence in Adrenocortical Biology and Its Disorders
Gao, X., Li, F., Liu, B., Wang, Y.-X., Wang, Y., & Zhou, H. (2021) · Cells · doi:10.3390/cells10123474 · Cited by 12
[Physiology of androgens in adult men].
Tostain, J.-B., Rossi, D., & Martin, P. (2004) · PubMed · Cited by 12
CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study
Ackermann, D., Pruijm, M. T., Ponte, B., Guessous, I., Ehret, G., Escher, G., Dick, B., Alwan, H., Vuistiner, P., Paccaud, F., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv138 · Cited by 12
Sexual Dysfunction in Men and Women
Bhasin, S., & Basson, R. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00020-4 · Cited by 15
Ziegler, E., Bodusch, M., Song, Y., Jahn, K., Wolfes, H., Steinlechner, S., Dengler, R., Bufler, J., & Krampfl, K. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0440-x · Cited by 12
Endocrine pathways in differential well-being across the life course
Worthman, C. M., & Barrett-Connor, E. L. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780192632890.003.0010 · Cited by 12
Labrie, F. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.00883 · Cited by 12
Self-citationLeBoff, M. S., & Glowacki, J. (1999) · Elsevier eBooks · doi:10.1016/b978-012098655-2/50017-x · Cited by 13
Pinna, G., & Bortolato, M. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106438 · Cited by 12
New insights into the protective effects of DHEA 1)
Niro, S., Hennebert, O., & Morfin, R. F. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.050 · Cited by 11
Helo, S., Wynia, B., & McCullough, A. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.03.003 · Cited by 11
DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders
Çelik, Ö., Acet, M., İmren, A., Çelik, N., Erşahin, A., Aktün, L. H., Otlu, B., Çelik, S., Çalışkan, E., & Ünlü, C. (2017) · Journal of the Turkish-German Gynecological Association · doi:10.4274/jtgga.2017.0054 · Cited by 11
Koundourakis, N. E., & Margioris, A. N. (2019) · HORMONES · doi:10.1007/s42000-019-00115-7 · Cited by 11
A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization
Shaw, I., Kirkwood, P. M., Rebourcet, D., Cousins, F. L., Ainslie, R. J., Livingstone, D. E. W., Smith, L. B., Saunders, P. T. K., & Gibson, D. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1027164 · Cited by 11
Endocrine and metabolic changes in human aging
Banks, W. A., & Morley, J. E. (2000) · AGE · doi:10.1007/s11357-000-0011-z · Cited by 11
Increased body fat mass and androgen metabolism – A twin study in healthy young women
Vihma, V., Heinonen, S., Naukkarinen, J., Kaprio, J. A., Rissanen, A., Turpeinen, U., Hämäläinen, E. K., Hakkarainen, A., Lundbom, J., Lundbom, N. M. I., et al. (2018) · Steroids · doi:10.1016/j.steroids.2018.08.006 · Cited by 11
Estrogen deficiency and the pathogenesis of osteoporosis
Khosla, S., & Pacifici, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00032-0 · Cited by 13
Sexualhormone und trockenes Auge
Schirra, F., Seitz, B., Knop, N., & Knop, E. (2009) · Der Ophthalmologe · doi:10.1007/s00347-009-2005-2 · Cited by 11
Wang, F., Wang, W., Wähälä, K., Adlercreutz, H., Ikonen, E., & Tikkanen, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90527.2008 · Cited by 11
Boger-Megiddo, I., Weiss, N. S., Barnett, M. J., Goodman, G. E., & Chen, C. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0238 · Cited by 11
Kancheva, L., Hill, M., Včeláková, H., Vrbíková, J., Pelikánová, T., & Stárka, L. (2007) · Steroids · doi:10.1016/j.steroids.2007.06.006 · Cited by 11
Effects on Androstenedione in Male Workers Exposed to Urban Stressors
Tomei, G., Ciarrocca, M., Capozzella, A., Rosati, M. V., Vacca, D., Ursini, A., Cangemi, C., Monti, C., & Tomei, F. (2006) · Inhalation Toxicology · doi:10.1080/08958370600596110 · Cited by 11
Stress biomarkers in the tear film
Banbury, L. K. (2009) · Cross Connect (Southern Cross University) · Cited by 11
Davis, S. R., Turcu, A. F., Robinson, P. J., & Bell, R. J. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00412 · Cited by 10
Takeshita, R. S. C., Bercovitch, F. B., Huffman, M. A., & Kinoshita, K. (2018) · International Journal of Primatology · doi:10.1007/s10764-018-0026-x · Cited by 10
Ondřejíková, L., Pařı́zek, A., Šimják, P., Vejražková, D., Velíková, M., Anderlová, K., Vosátková, M., Krejčí, H., Koucký, M., Kancheva, R. L., et al. (2021) · Biomolecules · doi:10.3390/biom11121746 · Cited by 10
Structure-function of DHEA binding proteins
Clark, B. J., & Klinge, C. M. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2022.12.002 · Cited by 11
Samson, M., Labrie, F., & Luu-The, V. (2009) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.009 · Cited by 10
Self-citationGundlach, N. H., Feldmann, M., Gundelach, Y., Gil, M. A., Siebert, U., Hoedemaker, M., & Schmicke, M. (2017) · Research in Veterinary Science · doi:10.1016/j.rvsc.2017.09.024 · Cited by 10
Nyce, J. W. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0241 · Cited by 10
Hypothalamic–Pituitary–Gonadal Axis in Men
Swerdloff, R. S., Wang, C., & Hikim, A. P. S. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00075-9 · Cited by 10
Aging in the Hypothalamic-Pituitary-Ovarian Axis
Neal-Perry, G. S., & Santoro, N. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50055-5 · Cited by 10
Haag, M., Hamann, T., Kulle, A. E., Riepe, F. G., Blatt, T., Wenck, H., Holterhus, P., & Peirano, R. I. (2012) · Dermato-Endocrinology · doi:10.4161/derm.19201 · Cited by 10
Riancho, J. A., Zarrabeitia, M. T., & Macías, J. G. (2008) · Aging Health · doi:10.2217/1745509x.4.4.365 · Cited by 10
Lin, T., Cai, Z., Wu, H., & Luo, L. (2016) · Florida Entomologist · doi:10.1653/024.099.0111 · Cited by 10
Circulating steroids negatively correlate with tinnitus
Chrbolka, P., Palúch, Z., Hill, M., & Alusik, S. (2017) · Steroids · doi:10.1016/j.steroids.2017.04.004 · Cited by 10
Campi, B., Frascarelli, S., Pietri, E., Massa, I., Donati, C., Bozic, R., Bertelloni, S., Paolicchi, A., Zucchi, R., & Saba, A. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0731-x · Cited by 10
Sex Differences in the Prevalence of Meibomian Gland Dysfunction: A Mini Review
Nøland, S. T., Magnø, M. S., Utheim, T. P., & Chen, X. (2024) · Current Eye Research · doi:10.1080/02713683.2023.2301325 · Cited by 9
Glaser, R. L., & Dimitrakakis, C. (2021) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2021.0003 · Cited by 9
Morphology of Meibomian Glands in a 65-Year-Old Norwegian Population without Dry Eye Disease
Chen, X., Badian, R. A., Hynne, H., Tashbayev, B., Hove, L. H., Jensen, J. L., & Utheim, T. P. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030527 · Cited by 9
Aging effects in adrenal cortex of male Mongolian gerbil: A model for endocrine studies
Zucão, M. I., Grigio, V., Guerra, L. H. A., Antoniassi, J. Q., Castro, N. F. D. C., Taboga, S. R., & Vilamaior, P. S. L. (2024) · Steroids · doi:10.1016/j.steroids.2024.109366 · Cited by 9
Roth, M. Y. (2012) · The AMA Journal of Ethic · doi:10.1001/virtualmentor.2012.14.2.stas1-1202 · Cited by 9
Bertin, J. O., Dury, A. Y., Ke, Y., Ouellet, J., & Labrie, F. (2015) · Steroids · doi:10.1016/j.steroids.2015.02.013 · Cited by 9
Self-citationBulant, J., Hill, M., Velíková, M., Yamamotová, A., Pavel Martasek, E., & Papežová, H. (2019) · Steroids · doi:10.1016/j.steroids.2019.108523 · Cited by 9
Metadata
- Authors
- Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Laboratory of Molecular Endocrinology, CHUL Research Center, Le Centre Hospitalier Universitaire de Québec, and Laval University, Québec, G1V 4G2, Canada
- ORCID
- Candas, Bernard
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-08-01
- Volume
- 82
- Issue
- 8
- Pages
- 2396-2402
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2009110883
- Cited by
- 713
- References
- 37
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 4 · 2023: 24 · 2022: 22 · 2021: 17 · 2020: 15 · 2019: 25 · 2018: 28 · 2017: 28 · 2016: 18 · 2015: 18 · 2014: 31 · 2013: 25 · 2012: 39
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- aging, dehydroepiandrosterone, DHEA sulfate, androstenedione, dihydrotestosterone, androstanol, androgen metabolism, sex steroids, sex differences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Androgens, Androstenedione, Dehydroepiandrosterone, Female, Humans, Male, Middle Aged, Pregnenolone, Protein Precursors, Reference Values, Gonadal Steroid Hormones, Dihydrotestosterone, 17-Hydroxysteroid Dehydrogenases, Androstenediol, Dehydroepiandrosterone Sulfate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
