The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging
Abstract
The present data show a dramatic decline in the circulating levels of dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEA-S), androst-5-ene-3β,17β-diol (5-diol), 5-diol-sulfate, 5-diol-fatty acid esters, and androstenedione in both men and women between the ages of 20–80 yr. In the 50- to 60-yr-old group, serum DHEA decreased by 74% and 70% from its peak values in 20- to 30-yr-old men and women, respectively. The serum concentrations of the conjugated metabolites of dihydrotestosterone (DHT), namely androsterone (ADT)-G, androstane-3α,17β-diol (3α-diol-G), androstane-3β,17β-diol (3β-diol-G), and ADT-sulfate are the most reliable parameters of the total androgen pool in both men and women, whereas serum testosterone and DHT can be used as markers of testicular secretion in men and interstitial ovarian secretion in women. The serum concentration of these various conjugated androgen metabolites decreased by 40.8% to 72.8% between the 20- to 30-yr-old and 70- to 80-yr-old age groups in men and women, respectively, thus suggesting a parallel decrease in the total androgen pool with age. As estimated by measurement of the circulating levels of these conjugated metabolites of DHT, it is noteworthy that women produce approximately 66% of the total androgens found in men. In women, most of these androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues, whereas in men the testes and DHEA and DHEA-S provide approximately equal amounts of androgens at the age of 50–60 yr. An additional potentially highly significant observation is that the majority of the marked decline in circulating adrenal C19 steroids and their resulting androgen metabolites takes place between the age groups of 20- to 30-yr olds and 50- to 60-yr-olds, with smaller changes are observed after the age of 60 yr.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Dihydroepiandrosterone sulphate is a precursor to testosterone, with concentrations that also decrease with ageing—in men aged 70–80 years, dihydroepiandrosterone sulphate concentrations are only about 20% of their peak concentrations at the age of 20 years.78”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [78]
In the citing paper
“in the 50-to 60-yr-old age group, serum DHEA has already decreased by 70%, compared with the 20-to 30-yr-old peak values (Ref.23; Fig. 1).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“Serum androgens as well as their precursors and metabolites decrease from the age of 30 -40 yr in women”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“As assessed by measurement of the circulating levels of these conjugated metabolites of DHT, it can be estimated that women produce approximately 71% or two thirds of the total androgens synthesized in men (Table 1);”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“an estimate of the relative amount of total androgens in women and men calculated on the basis of the sum of the serum concentrations of these three metabolites suggests that total androgen production in women is more than two thirds, or 71%, of that observed in men (23,27).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“the changes in precursor androgen secretion by the adrenals precede by 10 -20 yr the detectable decrease in ovarian steroidogenesis that occurs abruptly at menopause (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“in women, most of these androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“thus suggesting a parallel decrease in the total androgen pool with age (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“The serum concentration of the aboveindicated conjugated androgen metabolites decreases by 47.5-72.7% between the 20-to 30-and 70-to 80-yr age groups in women,”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“the pool of androgens in women decreases progressively from the age of 30 yr in parallel with the decrease in the serum concentration of DHEA and DHEA-S (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In the citing paper
“The decline of testosterone and DHEA (23,26,321,322) with age could be at least partially responsible for sarcopenia in older men and women.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685
Self-citationChanges in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437
Self-citationNeuronal migration and contact guidance in the primate telencephalon.
RAKIC, P. T. (1978) · PubMed · Cited by 395
Vermeulen, A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-221 · Cited by 384
The, V. L., Lachance, Y., Labrie, C., Leblanc, G., Thomas, J. L., Strickler, R. C., & Labrie, F. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1310 · Cited by 309
Self-citationComplete androgen blockade for the treatment of prostate cancer.
Labrie, F., Dupont, A., & Bèlanger, A. (1985) · PubMed · Cited by 285
Self-citationDHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 709
Estrogen, Bone Homeostasis, and Osteoporosis
Riggs, B. L., Khosla, S., & Melton, L. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50042-2 · Cited by 9
Role of Stress and Hormones of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Aging
Gupta, A. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_12 · Cited by 8
Anusuya, V., Nagar, A., Tandon, P., Singh, G., Singh, G. P., & Mahdi, A. A. (2020) · Progress in Orthodontics · doi:10.1186/s40510-020-00317-5 · Cited by 8
Alebić, M. Š., Stojanović, N., & Žuvić-Butorac, M. (2013) · International Journal of Endocrinology · doi:10.1155/2013/637919 · Cited by 8
Belic, A., Temesvári, M., Köhalmy, K., Vrzal, R., Dvořák, Z., Rozman, D., & Monostory, K. (2009) · Current Drug Metabolism · doi:10.2174/138920009790820147 · Cited by 8
Pepe, G. J., Maniu, A., Aberdeen, G. W., Lynch, T. J., & Albrecht, E. D. (2016) · Endocrinology · doi:10.1210/en.2015-2087 · Cited by 8
Sex Hormones, Menstrual Cycle and Resistance Exercise
Nakamura, Y., & Aizawa, K. (2016) · Springer eBooks · doi:10.1007/978-3-319-44558-8_14 · Cited by 8
Dehydroepiandrosterone (DHEA) and DHEA Sulfate: Roles in Brain Function and Disease
Quinn, T., Robinson, S. R., & Walker, D. W. (2018) · InTech eBooks · doi:10.5772/intechopen.71141 · Cited by 10
Effects of dehydroepiandrosterone on aldosterone release in rat zona glomerulosa cells
Chang, L., Wun, W.-S. A., & Wang, P. S. (2008) · Journal of Biomedical Science · doi:10.1007/s11373-008-9241-3 · Cited by 8
Geisthövel, F., Wacker, A., Brabant, G. E., Botsch, F., Maechtel, A., Wetzka, B., & Ochsner, A. (2010) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 8
Features and influences on the normal tear evaporation rate
Monfared, N., & Murphy, P. J. (2023) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2022.101809 · Cited by 7
Aspinall, S. R., Cook, D. B., Shenton, B. K., Griffiths, A. B., Griffith, C. D. M., Bliss, R., & Lennard, T. W. J. (2003) · The Breast · doi:10.1016/s0960-9776(02)00264-3 · Cited by 7
Anabolic hormone profiles in elite military men: Robust associations with age, stress, and fatigue
Taylor, M. K., Padilla, G. A., & Hernández, L. M. (2017) · Steroids · doi:10.1016/j.steroids.2017.05.010 · Cited by 7
Dry eye and dry skin - is there a connection?
Petriček, I., Pauk, S. V., Tomić, M., & Bulum, T. (2021) · Ophthalmic Epidemiology · doi:10.1080/09286586.2021.2021539 · Cited by 7
Association between urinary glyphosate exposure and bone mineral density in adults
Wang, Z., Zhang, H., Du, W., Hu, J., & Quan, R. (2023) · Medicine · doi:10.1097/md.0000000000036506 · Cited by 7
Insuficiência androgênica na mulher e potenciais riscos da reposição terapêutica
Leão, L. M. C. S. M., Duarte, M. P. C., & Farias, M. L. F. (2005) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302005000200006 · Cited by 7
Kulak, J., Urbanetz, A. A., Kulak, C. A. M., Borba, V. Z. C., & Boguszewski, C. L. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000800019 · Cited by 7
DHEA: Biology and Use in Therapeutic Intervention
Buster, J. E., & Casson, P. R. (2000) · Elsevier eBooks · doi:10.1016/b978-012453790-3/50045-7 · Cited by 7
Hypothalamic-Pituitary-Gonadal Axis in Men
Swerdloff, R. S., Wang, C., & Hikim, A. P. S. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50085-8 · Cited by 7
Medraś, M., Rogucka, E., & Jankowska, E. A. (1999) · The Aging Male · doi:10.3109/13685539909003172 · Cited by 7
Senescence Ecology: Aging in a Population of Wild Brown Mouse Lemurs (Microcebus rufus)
Zohdy, S. (2012) · Työväentutkimus Vuosikirja · doi:10.13140/rg.2.1.1825.4881 · Cited by 7
Effects of Psychosocial Stress on DHEA and DHEA-S levels Acute and Long-term effects
Lennartsson, A.-K. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 7
Persson, S., Ubhayasekera, K. A., Bergquist, J., Türkmen, Ş., Poromaa, I. S., & Elenis, E. (2022) · Biomedicines · doi:10.3390/biomedicines11010096 · Cited by 6
Meibomian Gland Assessment in Routine Ophthalmology Practice
Petriček, I., Tomić, M., Bulum, T., Gaćina, D. L., & Pauk, S. V. (2023) · Metabolites · doi:10.3390/metabo13020157 · Cited by 6
Early Castration in Horses Does Not Impact Osteoarticular Metabolism
Rouge, M., Legendre, F., Elkhatib, R., Delalande, C., Cognié, J., Reigner, F., Barrière, P., Deleuze, S. C., Hanoux, V., Galéra, P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316778 · Cited by 6
Serum testosterone bioassay evaluation in a large male cohort
Need, E. F., O’Loughlin, P. D., Armstrong, D. T., Haren, M. T., Martin, S., Tilley, W. D., Study, T. F. A. M. A., Wittert, G., & Buchanan, G. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03595.x · Cited by 6
Hypoactive Sexual Desire Disorder in Premenopausal Women: Case Studies
Miner, M. M., D, R. S. M., & Buster, J. E. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.01.2522 · Cited by 6
Diagnosis and Treatment of Hypoactive Sexual Desire Disorder
Amato, P., & Buster, J. E. (2009) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3181bf48c9 · Cited by 6
The role of androgens in hormone replacement therapy
Johnson, C., & Berman, J. R. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.11.1815 · Cited by 6
AGE RELATED DIFFERENCE IN THE LIPID PROFILE IN NORMAL HEALTHY WOMEN
Deepti, G. I., Shetty, S., Rao, A. V., & Ahmad, S. (2014) · Journal of Health and Allied Sciences NU · doi:10.1055/s-0040-1703771 · Cited by 6
Perna, V., Taylor, N., Dorota Dworakowska, B., Schulte, K., Aylwin, S. J. B., Al‐Hashimi, F., & Díaz‐Cano, S. J. (2014) · Clinical Endocrinology · doi:10.1111/cen.12458 · Cited by 6
Esfahani, A., Kendall, C. W. C., Bashyam, B., Archer, M. C., & Jenkins, D. J. A. (2010) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-010-9351-x · Cited by 6
Problems with Arousal and Orgasm in Women
Meston, C. M., Seal, B. N., & Hamilton, L. D. (2008) · Wiley eBooks · doi:10.1002/9781118269978.ch7 · Cited by 6
Parker, C. R. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199906000-00007 · Cited by 6
Ohlsson, C., Li, L., Horkeby, K., Lawenius, L., Colldén, H., Sjögren, K., Baldanzi, G., Engström, G., Ärnlöv, J., Orho‐Melander, M., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105978 · Cited by 5
Sultana, F., Davis, S. R., & Islam, R. M. (2023) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002251 · Cited by 5
Wang, Y., Islam, R. M., Hussain, S. M., McNeil, J. J., & Davis, S. R. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad287 · Cited by 5
Pathogenesis of Obstructive Sleep Apnea in Obesity
Patil, S. P., & Kirkness, J. P. (2024) · Respiratory medicine · doi:10.1007/978-3-031-52696-1_6 · Cited by 5
Impact of Hormones on Female Sexual Function and Dysfunction
Sandhu, K. S., Melman, A., & Mikhail, M. S. (2011) · Urogynecology · doi:10.1097/spv.0b013e318204491f · Cited by 5
Sex hormones and dry eye disease: Current update
Maurya, R. P., Gupta, A. O., Verma, S., Singh, V. P., Singh, A. K., Singh, V., Roy, M., Mehla, L., & Kumar, R. (2021) · IP International Journal of Ocular Oncology and Oculoplasty · doi:10.18231/j.ijooo.2021.029 · Cited by 5
Neto, J. M. D. A., Coelho, H. S. M., Chindamo, M. C., Rezende, G. F. M., Pannain, V. L., Bottino, A., Porto, L. F. B., Luiz, R. R., Villela‐Nogueira, C. A., & Perez, R. D. M. (2017) · Journal of Viral Hepatitis · doi:10.1111/jvh.12812 · Cited by 5
Carrer, P., Trevisan, C., Franchin, A., Volpe, E. D., Rancan, A., Zanforlini, B. M., Maggi, S., Noale, M., Corti, M. C., Perissinotto, E., et al. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.07.003 · Cited by 5
Metabolismus von Dehydroepiandrosteron durch Epidermophyton floccosum
Brasch, J., Flader, S. M., Roggentin, P., Wudy, S., Homoki, J., Shackleton, C. H. L., & Sipell, W. (2002) · Mycoses · doi:10.1111/j.1439-0507.2002.tb04544.x · Cited by 5
Goncharov, N. P., & Katzija, G. (1998) · The Aging Male · doi:10.3109/13685539809146108 · Cited by 4
Could dehydroepiandrosterone (DHEA) be a novel target for depression?
Souza‐Teodoro, L. H., Andrade, L. H., & Carvalho, L. A. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100340 · Cited by 4
Masi, A. T., Rehman, A. A., Cutolo, M., & Aldag, J. C. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12435 · Cited by 4
Santoro, N., & Wierman, M. E. (2021) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000658 · Cited by 4
Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period
Ali, E. B., Hamza, A., Zaboon, I. A., Alidrisi, H. A., & Mansour, A. A. (2023) · Cureus · doi:10.7759/cureus.35462 · Cited by 4
Sex Hormones and Immunosenescence
Gómez, C. R., Nomellini, V., & Kovacs, E. J. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_42 · Cited by 4
Pukhalsky, A. L., Шмарина, Г. В., & Aleshkin, V. A. (2014) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn.v69i5-6.1038 · Cited by 4
The Relaxation Response: A Strategy to Address Stress
Walsh, A. E. (2011) · International Journal of Athletic Therapy & Training · doi:10.1123/ijatt.16.2.20 · Cited by 4
The Role of Tandem Mass Spectrometry in Clinical Chemistry
Saba, A., Frascarelli, S., & Campi, B. (2017) · Comprehensive analytical chemistry · doi:10.1016/bs.coac.2017.06.011 · Cited by 4
Intracrinology: The New Science of Sex Steroid Physiology in Women
Labrie, F. (2018) · ISGE series · doi:10.1007/978-3-319-63540-8_1 · Cited by 4
Self-citationAutophagy may contribute to the recovery of rat mesothelium following acute inflammation in vivo
Balogh, P., Szabó, A., Likó, I., Patócs, A., & Kiss, A. L. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2188-6 · Cited by 4
Evaluation of the isoflavones and estrogen effects on the rat adrenal
Marinho, D. S., Calió, M. L., dos Santos, M. A., Ko, G. M., Teixeira, C. P., Carbonel, A. A. F., Lisbôa-Nascimento, T., Castro, R. A., Simões, R. S., & Bertoncini, C. R. A. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1318371 · Cited by 4
Normal Aging and the Menopausal Transition: What to Expect
Santoro, N., & Neal-Perry, G. S. (2009) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000209598 · Cited by 4
Obesity, Circulating Androgens and their Precursors
(2013) · Journal of Steroids & Hormonal Science · doi:10.4172/2157-7536.1000119 · Cited by 3
Computational method for aromatase-related proteins using machine learning approach
Selvaraj, M. K., & Kaur, J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283567 · Cited by 3
Sex Hormones, Menstrual Cycle, and Resistance Exercise
Nakamura, Y., & Aizawa, K. (2023) · Springer eBooks · doi:10.1007/978-3-031-21881-1_10 · Cited by 3
Wood, C. E., Stavisky, R. C., Nowak, J., & Kaplan, J. R. (2011) · Toxicologic Pathology · doi:10.1177/0192623311425509 · Cited by 3
When Periods Stop: Long-Term Consequences of PCOS
Carmina, E., Guastella, E., & Rizzo, M. (2009) · Springer eBooks · doi:10.1007/978-0-387-09718-3_23 · Cited by 3
DHEA as a biomarker of aging in humans and nonhuman primates
Urbanski, H. F. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818000-6.00025-1 · Cited by 3
Duffel, M. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00005-x · Cited by 3
Basic Roles of Sex Steroid Hormones in Wound Repair with Focus on Estrogens (A Review)
Čriepoková, Z., Lenhardt, Ľ., & Gál, P. (2016) · Folia veterinaria · doi:10.1515/fv-2016-0006 · Cited by 3
Management of Hypoactive Sexual Desire Disorder (HSDD)
Krapf, J. M., Buster, J. E., & Goldstein, A. T. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3100-2_21 · Cited by 3
Ke, Y., Dury, A. Y., Gonthier, R., & Labrie, F. (2018) · Clinical mass spectrometry · doi:10.1016/j.clinms.2018.08.003 · Cited by 3
Self-citationElliott, C. G., Vidal‐Almela, S., Harvey, P., O’Donnell, E., Scheid, J. L., Visintini, S. M., & Reed, J. L. (2022) · CJC Open · doi:10.1016/j.cjco.2022.10.008 · Cited by 3
Psychological Aspects of Hysterectomy & Postoperative Care
Majumdar, A., & Saleh, S. (2012) · InTech eBooks · doi:10.5772/31227 · Cited by 3
Roeca, C. M., Al-Safi, Z. A., & Santoro, N. F. (2015) · Cited by 3
Stute, P., Kalkhake, K., Kiesel, L., & Götte, M. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.943205 · Cited by 3
Mendell, A. L., MacLusky, N. J., & Léránth, C. (2013) · Neuroscience & Medicine · doi:10.4236/nm.2013.43021 · Cited by 3
Labrie, F. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.064 · Cited by 3
Self-citationAging, androgens, and female sexual desire: Can we restore what time takes away?
Buster, J. E. (2005) · Sexuality, reproduction & menopause · doi:10.1016/s1546-2501(05)00005-8 · Cited by 3
Lee, S. Y., Myung, S. C., Lee, M. Y., Kim, T., Kim, S. C., Kim, K. D., Park, S. H., & Kim, W. Y. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01397.x · Cited by 3
Kasperek, R., Gałczyński, K., Naleśniak, M., Iwaniak, K., & Poleszak, E. (2014) · Current Issues in Pharmacy and Medical Sciences · doi:10.2478/cipms-2014-0012 · Cited by 3
SERUM STEROID HORMONE RESPONSES TO ACUTE RESISTANCE EXERCISE
Aizawa, K., Akimoto, T., HAYASHI, K., Nakamura, M., Murai, F., & Mesaki, N. (2001) · 体力科學 · doi:10.7600/jspfsm1949.50.293 · Cited by 3
Sustratos hormonales de la respuesta sexual femenina
Mas, M. (2007) · Revista Internacional de Andrología · doi:10.1016/s1698-031x(07)74032-3 · Cited by 3
Rabe, T., Hj, A., Albring, C., Bachmann, A., Bitzer, J., Blume‐Peytavi, U., Egarter, C., Hinney, B., Kentenich, H., König, K. G., et al. (2016) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 3
Stress and Androgens in Himba Women
Prall, S. P., Scelza, B. A., & Trumble, B. C. (2023) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-023-00227-w · Cited by 2
Meamar, R., Feizi, A., Aminorroaya, A., Amini, M., Iraj, B., & Heidarpour, M. (2023) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_100_22 · Cited by 2
Nyce, J. W. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.89 · Cited by 2
Song, M., Jayasekara, H., Pelucchi, C., Rabkin, C. S., Johnson, K. C., Hu, J., Palli, D., Ferraroni, M., Liao, L. M., Bonzi, R., et al. (2023) · Cancer Causes & Control · doi:10.1007/s10552-023-01829-1 · Cited by 2
Pathogenesis of Obstructive Sleep Apnea in Obesity
Kirkness, J. P., & Patil, S. P. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-053-3_4 · Cited by 2
Testosterone, estradiol and men, and sex hormone binding globulin
Hogervorst, E., Henderson, V. W., Gibbs, R. B., & Brinton, R. D. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511635700.020 · Cited by 2
Duffel, M. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95623-x · Cited by 2
Tripathi, T., Ganesh, G., Singh, N., & Rai, P. (2022) · Journal of Orthodontics · doi:10.1177/14653125221118934 · Cited by 2
Robles, B. R., Valdez, R. A., Almaraz, M. H., Mayorga, S. R. C., Mata‐Espinosa, D., Barrios‐Payán, J., Hernández‐Pando, R., & Romano, M. C. (2022) · Tuberculosis · doi:10.1016/j.tube.2022.102274 · Cited by 2
Effect of age on androgens pattern in cyclic mares
Satué, K., Fazio, E., Damiá, E., Barbiera, G., Medica, P., & Cravana, C. (2024) · Research in Veterinary Science · doi:10.1016/j.rvsc.2024.105276 · Cited by 2
Plazebokontrollierte DHEA-Substitution beim älteren Mann
REITER, W. J., & Pycha, A. (1999) · Gyn�kologisch-geburtshilfliche Rundschau · doi:10.1159/000022313 · Cited by 2
Somboonporn, W. (2006) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000233938.36554.37 · Cited by 2
Uneståhl, L., & Johansson, B. (2013) · Psychology · doi:10.4236/psych.2013.47087 · Cited by 2
Nakanishi, T. (2013) · Journal of Cancer Research and Therapeutic Oncology · doi:10.17303/jcrto.2013.1.101 · Cited by 2
Impact of circulating dehydroepiandrosterone on androgen formation in women
Labrie, F. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182146d7f · Cited by 2
Self-citation2D:4D digit ratio and its relations to cross-sex and same-sex friendship choices
Altmann, T., & Roth, M. (2018) · Personality and Individual Differences · doi:10.1016/j.paid.2018.06.034 · Cited by 2
Szoeke, C. E. I., Downie, S., Phillips, S., & Campbell, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819344-0.00011-9 · Cited by 2
Hormonal Interventions of Aging and Longevity
Thakur, M. K. (2003) · Springer eBooks · doi:10.1007/978-94-017-0283-6_13 · Cited by 2
Esteroides sexuales y hueso: ¿tiene sexo el hueso?
Fernández, E. G., Iglesias, S. G., Salinas, H. R., Gimeno, E. J., & Carranza, F. H. (2005) · Revista Española de Enfermedades Metabólicas Óseas · doi:10.1016/s1132-8460(05)72668-4 · Cited by 2
Tobiansky, D. J. (2018) · Current Sexual Health Reports · doi:10.1007/s11930-018-0175-0 · Cited by 2
Donskov, J. G. (2021) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2021.12 · Cited by 2
Rationale for Treating Hypoandrogenism in Women
Davis, S. R. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-388-0_19 · Cited by 2
Metadata
- Authors
- Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Laboratory of Molecular Endocrinology, CHUL Research Center, Le Centre Hospitalier Universitaire de Québec, and Laval University, Québec, G1V 4G2, Canada
- ORCID
- Candas, Bernard
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-08-01
- Volume
- 82
- Issue
- 8
- Pages
- 2396-2402
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2009110883
- Cited by
- 713
- References
- 37
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 4 · 2023: 24 · 2022: 22 · 2021: 17 · 2020: 15 · 2019: 25 · 2018: 28 · 2017: 28 · 2016: 18 · 2015: 18 · 2014: 31 · 2013: 25 · 2012: 39
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- aging, dehydroepiandrosterone, DHEA sulfate, androstenedione, dihydrotestosterone, androstanol, androgen metabolism, sex steroids, sex differences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Androgens, Androstenedione, Dehydroepiandrosterone, Female, Humans, Male, Middle Aged, Pregnenolone, Protein Precursors, Reference Values, Gonadal Steroid Hormones, Dihydrotestosterone, 17-Hydroxysteroid Dehydrogenases, Androstenediol, Dehydroepiandrosterone Sulfate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
