Brief review: Glucocorticoid excretion in obesity

Müssig, Karsten; Remer, Thomas; Maser-Gluth, Christiane

doi:10.1016/j.jsbmb.2010.01.008

Cited by 36Stress Responses and CortisolAdipokines, Inflammation, and Metabolic DiseasesAdrenal Hormones and Disorders

Brief review: Glucocorticoid excretion in obesity

Müssig, Karsten, Remer, Thomas, Maser-Gluth, Christiane·2010·The Journal of Steroid Biochemistry and Molecular Biology

DOI 10.1016/j.jsbmb.2010.01.008

Open this paper in CoChat — free account

Abstract

Cortisol secretion and glucocorticoid excretion rates are regularly increased in obesity and associate with indices of body size and visceral adiposity. Different mechanisms may underlie the elevated urinary excretion rates of cortisol metabolites in obesity. In the present brief overview, potential mechanisms are discussed, paying special attention to cortisol metabolism. Besides, potential confounding factors in the evaluation of urinary glucocorticoid excretion are highlighted.

Integrity signals

Registry

Crossref · 10.1016/j.jsbmb.2010.01.008

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Improvements from altering health behaviors appear to stem from endocrinological changes that occur with overfatness and following exposure to exercise.
“Where these improvements appear to stem from a number of endocrinological changes that occur with both expression of overfatness and following exposure to exercise that ultimately alters the health status for the individual who is overfat [18,19,26,28,30,32-34].”
From Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18–65 years old) who are overfat, or obese; systematic review and meta-analysis (2015) · cites this paper as [33]
Altering any health behaviors leads to a reduction in the risk factors for preventable non-communicable diseases.
“Even if it is well understood that altering any health behaviors leads to a reduction in the risk factors for preventable non-communicable diseases [18,20,26-33].”
From Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18–65 years old) who are overfat, or obese; systematic review and meta-analysis (2015) · cites this paper as [33]
High circulating insulin is a key indicator for metabolic health issues in overfat adults.
“one of the key indicators for metabolic health issues for adults that are overfat is high levels of circulating insulin”
From Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18–65 years old) who are overfat, or obese; systematic review and meta-analysis (2015) · cites this paper as [33]

A transgenic model of visceral obesity and the metabolic syndrome
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766 · see citing works
Metabolic Implications of Body Fat Distribution
Björntorp, P. A. (1991) · Diabetes Care · doi:10.2337/diacare.14.12.1132 · Cited by 1,056 · see citing works
11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
Kotelevtsev, Y. V., Holmes, M. C., Burchell, A. N., Houston, P., Schmoll, D., Jamieson, P. M., Best, R., Brown, R., Edwards, C. R. W., Seckl, J. R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14924 · Cited by 858 · see citing works
Glucocorticoids and insulin resistance: old hormones, new targets
ANDREWS, R. C., & WALKER, B. R. (1999) · Clinical Science · doi:10.1042/cs0960513 · Cited by 731 · see citing works
Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity
Rask, E., Olsson, T., Söderberg, S., Andrew, R., Livingstone, D. E. W., Johnson, O., & Walker, B. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7453 · Cited by 657 · see citing works
Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice
Morton, N. M., Paterson, J. M., Masuzaki, H., Holmes, M. C., Staels, B., Fievet, C., Walker, B. R., Flier, J. S., Mullins, J. J., & Seckl, J. R. (2004) · Diabetes · doi:10.2337/diabetes.53.4.931 · Cited by 512 · see citing works
Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity.
Rask, E., Walker, B., Söderberg, S., Livingstone, D., Eliasson, M., Johnson, O., Andrew, R., & Olsson, T. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.7.8661 · Cited by 467 · see citing works
Cortisol secretion in relation to body fat distribution in obese premenopausal women
Mårin, P., Darin, N., Amemiya, T., Andersson, B., Jern, S., & Björntorp, P. (1992) · Metabolism · doi:10.1016/0026-0495(92)90171-6 · Cited by 458 · see citing works
Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice
Morton, N. M., Holmes, M. C., Fiévet, C., Staels, B., Tailleux, A., Mullins, J. J., & Seckl, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103676200 · Cited by 441 · see citing works
Stress hormones: physiological stress and regulation of metabolism
Kyrou, I., & Tsigos, C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.08.007 · Cited by 440 · see citing works
Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice
Paterson, J. M., Morton, N. M., Fiévet, C., Kenyon, C. J., Holmes, M. C., Staels, B., Seckl, J. R., & Mullins, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305524101 · Cited by 427 · see citing works
Multifactorial causation of obesity: implications for prevention
Grundy, S. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.3.563s · Cited by 403 · see citing works
Cortisol Metabolism in Human Obesity: Impaired Cortisone→Cortisol Conversion in Subjects with Central Adiposity<sup>1</sup>
Stewart, P. M., Boulton, A., Kumar, S., Clark, P. M. S., & Shackleton, C. H. L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5538 · Cited by 398 · see citing works
Obesity: Genetic, molecular, and environmental aspects
Barness, L. A., Opitz, J. M., & Gilbert‐Barness, E. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32035 · Cited by 373 · see citing works
Cortisol Effects on Body Mass, Blood Pressure, and Cholesterol in the General Population
Fraser, R., Ingram, M. C., Anderson, N., Morrison, C. E., Davies, E., & Connell, J. (1999) · Hypertension · doi:10.1161/01.hyp.33.6.1364 · Cited by 371 · see citing works
The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution
Pasquali, R., Cantobelli, S., Casimirri, F., Capelli, M., Bortoluzzi, L., Flamia, R., Labate, A. M., & Barbara, L. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.2.8393881 · Cited by 366 · see citing works
Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men.
Fried, S. K., Russell, C. D., Grauso, N. L., & Brolin, R. E. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116821 · Cited by 356 · see citing works
Obesity and Gender Influence Cortisol Secretion and Metabolism in Man
Andrew, R., Phillips, D. I. W., & Walker, B. R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4951 · Cited by 351 · see citing works
Understanding the Role of Glucocorticoids in Obesity: Tissue-Specific Alterations of Corticosterone Metabolism in Obese Zucker Rats1
Livingstone, D. E. W., Jones, G. C., Smith, K., Jamieson, P. M., Andrew, R., Kenyon, C. J., & Walker, B. R. (2000) · Endocrinology · doi:10.1210/endo.141.2.7297 · Cited by 348 · see citing works
Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus
Björntorp, P. A., Holm, G., & Rosmond, R. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00067.x · Cited by 322 · see citing works
Glucocorticoids and insulin resistance: old hormones, new targets
Andrews, R. C., & Walker, B. R. (1999) · Clinical Science · doi:10.1042/cs19980388 · Cited by 266 · see citing works
Expression of the mRNA Coding for 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue from Obese Patients: Anin SituHybridization Study
Paulmyer‐Lacroix, O., Boullu, S., Oliver, C., Alessi, M., & Grino, M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8614 · Cited by 241 · see citing works
Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Activity and Messenger Ribonucleic Acid Levels Are Associated with Adiposity and Insulinemia in Pima Indians and Caucasians
Lindsay, R. S., Wake, D. J., Nair, S., Bunt, J., Livingstone, D. E. W., Permana, P. A., Tataranni, P. A., & Walker, B. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-030017 · Cited by 225 · see citing works
STUDY OF ADRENOCORTICAL FUNCTION IN OBESITY.
Migeon, C. J., GREEN, O. C., & Jp, E. (1963) · PubMed · Cited by 224 · see citing works
Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women
Purnell, J. Q., Brandon, D. D., Isabelle, L. M., Loriaux, D. L., & Samuels, M. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030440 · Cited by 199 · see citing works
Chronic stress and obesity in adolescents: Scientific evidence and methodological issues for epidemiological research
Vriendt, T. D., Moreno, L. A., & Henauw, S. D. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.02.009 · Cited by 178 · see citing works
Cortisol metabolism and the role of 11β-hydroxysteroid dehydrogenase
Tomlinson, J., & Stewart, P. M. (2001) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2000.0119 · Cited by 165 · see citing works
Metabolic Consequences and Vulnerability to Diet-Induced Obesity in Male Mice under Chronic Social Stress
Bartolomucci, A., Cabassi, A., Govoni, P., Ceresini, G., Cero, C., Berra, D., Dadomo, H., Franceschini, P., Dell’Omo, G., Parmigiani, S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004331 · Cited by 165 · see citing works
11β‐Hydroxysteroid Dehydrogenase Type 1 mRNA is Increased in Both Visceral and Subcutaneous Adipose Tissue of Obese Patients
Desbrière, R., Vuaroqueaux, V., Achard, V., Boullu‐Ciocca, S., Labuhn, M., Dutour, A., & Grino, M. (2006) · Obesity · doi:10.1038/oby.2006.92 · Cited by 156 · see citing works
Cortisol production in obesity
Strain, G. W., Zumoff, B., Strain, J. J., Levin, J., & Fukushima, D. K. (1980) · Metabolism · doi:10.1016/0026-0495(80)90043-8 · Cited by 151 · see citing works
Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study.
Pasquali, R., Ambrosi, B., Armanini, D., Cavagnini, F., Uberti, E. D., del Rio, G., Pergola, G. D., Maccario, M., Mantero, F., Marugo, M., et al. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.1.8158 · Cited by 149 · see citing works
CRH-stimulated cortisol release and food intake in healthy, non-obese adults
George, S. A., Khan, S. A., Briggs, H., & Abelson, J. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.017 · Cited by 141 · see citing works
Resistance to Glucocorticoid Feedback in Obesity
Jessop, D. S., Dallman, M. F., Fleming, D., & Lightman, S. L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7826 · Cited by 141 · see citing works
Perceived Racism in Relation to Weight Change in the Black Women's Health Study
Cozier, Y. C., Wise, L. A., Palmer, J. R., & Rosenberg, L. A. (2009) · Annals of Epidemiology · doi:10.1016/j.annepidem.2009.01.008 · Cited by 140 · see citing works
Stress‐related Development of Obesity and Cortisol in Women
Vicennati, V., Pasqui, F., Cavazza, C., Pagotto, U., & Pasquali, R. (2009) · Obesity · doi:10.1038/oby.2009.76 · Cited by 138 · see citing works
Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation
Shively, C. A., Register, T. C., & Clarkson, T. B. (2009) · American Journal of Primatology · doi:10.1002/ajp.20706 · Cited by 121 · see citing works
Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol
Strain, G. W., Zumoff, B., Kream, J., Strain, J. J., Levin, J., & Fukushima, D. K. (1982) · Metabolism · doi:10.1016/0026-0495(82)90054-3 · Cited by 114 · see citing works
High fluid intake increases urine free cortisol excretion in normal subjects.
Mericq, M. V., & Cutler, G. B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4555 · Cited by 111 · see citing works
Fat distribution in obese women is associated with subtle alterations of the hypothalamic–pituitary–adrenal axis activity and sensitivity to glucocorticoids
Duclos, M., Gatta‐Cherifi, B., Corcuff, J., Rashedi, M., Péhourcq, F., & Roger, P. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01384.x · Cited by 105 · see citing works
Omental 11β‐hydroxysteroid Dehydrogenase 1 Correlates with Fat Cell Size Independently of Obesity
Michailidou, Z., Jensen, M. D., Dumesic, D. A., Chapman, K. E., Seckl, J. R., Walker, B. R., & Morton, N. M. (2007) · Obesity · doi:10.1038/oby.2007.618 · Cited by 102 · see citing works
Comparison of the Characteristics of Increased Adrenocortical Function in Obesity and in Cushing's Syndrome
SCHTEINGART, D. E., Gregerman, R. I., & Conn, J. W. (1963) · JAMA · doi:10.1001/jama.1963.03700240117102 · Cited by 96 · see citing works
Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss
Tomlinson, J. W., Finney, J., Hughes, B. A., Hughes, S. V., & Stewart, P. M. (2008) · Diabetes · doi:10.2337/db08-0094 · Cited by 91 · see citing works
Cortisol Metabolism in Obesity
DUNKELMAN, S. S., Fairhurst, B. J., Plager, J. E., & Waterhouse, C. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-9-832 · Cited by 85 · see citing works
Adrenocortical activity in healthy children is associated with fat mass
Dimitriou, T., Maser‐Gluth, C., & Remer, T. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.3.731 · Cited by 77 · see citing works
Self-citation
Adipose tissue 11β-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing’s syndrome
Mariniello, B., Ronconi, V., Rilli, S., Bernante, P., Boscaro, M., Mantero, F., & Giacchetti, G. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02228 · Cited by 75 · see citing works
Glucocorticoid Measurements in Health and Disease - Metabolic Implications and the Potential of 24-h Urine Analyses
Remer, T., Maser‐Gluth, C., & Wudy, S. A. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708783498096 · Cited by 73 · see citing works
Self-citation
Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women
Goedecke, J. H., Wake, D. J., Levitt, N. S., Lambert, E. V., Collins, M. R., Morton, N. M., Andrew, R., Seckl, J. R., & Walker, B. R. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02552.x · Cited by 67 · see citing works
THE CORTISOL RESPONSE TO CORTICOTROPHIN‐RELEASING FACTOR IS BLUNTED IN OBESITY
Kopelman, P. G., Grossman, A. B., Lavender, P., BESSER, G. M., REES, L. H., & Coy, D. H. (1988) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1988.tb01197.x · Cited by 59 · see citing works
Adrenal Gland Volume Determination by Computed Tomography and Magnetic Resonance Imaging in Normal Subjects
Rubín, R. T., & Phillips, J. J. (1991) · Investigative Radiology · doi:10.1097/00004424-199105000-00015 · Cited by 47 · see citing works
11-β Hydroxysteroid dehydrogenase type 2 expression in white adipose tissue is strongly correlated with adiposity
Milagro, F. I., Campión, J., & Martínez, J. A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.10.006 · Cited by 46 · see citing works
Abdominal obesity increases overnight cortisol excretion.
Duclos, M., Corcuff, J.-B., Etcheverry, N., Rashedi, M., Tabarin, A., & Roger, P. (1999) · Journal of Endocrinological Investigation · doi:10.1007/bf03343591 · Cited by 42 · see citing works
Urinary free cortisol and cortisone excretion in healthy individuals: Influence of water loading
Fenske, M. J. (2006) · Steroids · doi:10.1016/j.steroids.2006.08.004 · Cited by 40 · see citing works
Acute Effects of Stress-Reduction Interactive Guided Imagery SM on Salivary Cortisol in Overweight Latino Adolescents
Weigensberg, M. J., Lane, C. J., Winners, O., Wright, T. G., Nguyen‐Rodriguez, S. T., Goran, M. I., & Spruijt‐Metz, D. (2009) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2008.0156 · Cited by 36 · see citing works
Influence of Body Composition on Adrenal Function in Obesity
PREZIO, J. A., CARREON, G. G., CLERKIN, E., MELONI, C. R., Kyle, L. H., & Canary, J. J. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-6-481 · Cited by 36 · see citing works
11β‐Hydroxysteroid Dehydrogenase 2 Activity Is Elevated in Severe Obesity and Negatively Associated With Insulin Sensitivity
Müssig, K., Remer, T., Haupt, A., Gallwitz, B., Fritsche, A., Häring, H., & Maser‐Gluth, C. (2008) · Obesity · doi:10.1038/oby.2008.218 · Cited by 34 · see citing works
Self-citation
Free cortisol and creatinine in urine of healthy children.
Bertrand, P. V., Rudd, B. T., Weller, P., & Day, A. J. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.11.2047 · Cited by 33 · see citing works
Study of the effect of changing glucose, insulin, and insulin-like growth factor-I levels on serum corticosteroid binding globulin in lean, obese, and obese subjects with glucose intolerance
Fernández‐Real, J. M., PUGEAT, M. M., Emptoz-Bonneton, A., & Ricart, W. (2001) · Metabolism · doi:10.1053/meta.2001.25647 · Cited by 32 · see citing works
Increase of Visceral Fat and Adrenal Gland Volume in Women with Depression: Preliminary Results of a Morphometric Mri Study
Ludescher, B., Najib, A., Baar, S., Machann, J., Schick, F., Buchkremer, G., Claussen, C. D., & Eschweiler, G. W. (2008) · The International Journal of Psychiatry in Medicine · doi:10.2190/pm.38.3.a · Cited by 28 · see citing works
Reduction of plasma cortisol levels in childhood obesity
Chalew, S. A., Lozano, R. A., Armour, K. M., Zadik, Z., & Kowarski, A. A. (1991) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80302-6 · Cited by 24 · see citing works
Production Rates of Cortisol in Obesity
Vierhapper, H., Nowotny, P., & Waldhäusl, W. K. (2004) · Obesity Research · doi:10.1038/oby.2004.178 · Cited by 24 · see citing works
Daily urinary free cortisol and cortisone excretion is associated with urine volume in healthy children
Shi, L., Maser‐Gluth, C., & Remer, T. (2008) · Steroids · doi:10.1016/j.steroids.2008.08.002 · Cited by 22 · see citing works
Self-citation
Urinary Free Cortisol Is Unrelated to Physiological Changes in Urine Volume in Healthy Women
Putignano, P., Dubini, A., & Cavagnini, F. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.6.879 · Cited by 14 · see citing works
Urinary Free Cortisol Is Not Affected by Short-term Water Diuresis
Fenske, M. J. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.2.316 · Cited by 11 · see citing works
The use of CRF-41 in the differential diagnosis of Cushing's syndrome and obesity.
Grossman, A. B., Howlett, T. A., & Pg, K. (1987) · PubMed · Cited by 9 · see citing works
Urinary free cortisone, but not cortisol, is associated with urine volume in severe obesity
Müssig, K., Remer, T., Fritsche, A., Häring, H., & Maser‐Gluth, C. (2009) · Steroids · doi:10.1016/j.steroids.2009.03.007 · Cited by 8 · see citing works
Self-citation
The Integrated Concentration of Cortisone is Reduced in Obese Children
Chalew, S. A., Nagel, H., Burt, D., & Edwards, C. R. W. (1997) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1997.10.3.287 · Cited by 5 · see citing works

Flagged first, then by citations

Sorted by citations

Effects of obesity on bone metabolism
Cao, J. (2011) · Journal of Orthopaedic Surgery and Research · doi:10.1186/1749-799x-6-30 · Cited by 768 · see citing works
Cortisol in Hair and the Metabolic Syndrome
Tobias Stalder, A., Kirschbaum, C., Alexander, N., Bornstein, S. R., Gao, W., Miller, R. E., Stark, S., Bosch, J. A., & Fischer, J. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1056 · Cited by 237 · see citing works
Cortisol in hair, body mass index and stress-related measures
Tobias Stalder, A., Steudte‐Schmiedgen, S., Alexander, N., Miller, R. E., Gao, W., Dettenborn, L., & Kirschbaum, C. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.03.010 · Cited by 182 · see citing works
Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18–65 years old) who are overfat, or obese; systematic review and meta-analysis
Clark, J. E. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0154-1 · Cited by 158 · see citing works
Detrimental and protective fat: body fat distribution and its relation to metabolic disease
Booth, A. D., Magnuson, A. M., & Foster, M. T. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0009 · Cited by 98 · see citing works
Trait anxiety, but not trait anger, predisposes obese individuals to emotional eating
Schneider, K. L., Appelhans, B. M., Whited, M. C., Oleski, J. L., & Pagoto, S. (2010) · Appetite · doi:10.1016/j.appet.2010.10.006 · Cited by 93 · see citing works
Depression, obesity, and smoking were independently associated with inadequate glycemic control in patients with type 1 diabetes
Melin, E. O., Thunander, M., Svensson, R., Landin‐Olsson, M., & Thulesius, H. O. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0137 · Cited by 81 · see citing works
Disrupted Prenatal Maternal Cortisol, Maternal Obesity, and Childhood Wheeze. Insights into Prenatal Programming
Wright, R. O., Fisher, K. J., Chiu, Y.-H. M., Wright, R. O., Fein, R., Cohen, S., & Coull, B. A. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201208-1530oc · Cited by 66 · see citing works
Relation between salivary cortisol as stress biomarker and dietary pattern in children
Michels, N., Sioen, I., Braet, C., Huybrechts, I., Vanaelst, B., Wolters, M., & Henauw, S. D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.020 · Cited by 62 · see citing works
Increased cortisol level
Cagnacci, A., Cannoletta, M., Caretto, S., Zanin, R., Xholli, A., & Volpe, A. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181f31947 · Cited by 61 · see citing works
Partial Sleep Deprivation and Energy Balance in Adults: An Emerging Issue for Consideration by Dietetics Practitioners
Shlisky, J., Hartman, T. J., Kris‐Etherton, P. M., Rogers, C. J., Sharkey, N. A., & Nickols‐Richardson, S. M. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.07.032 · Cited by 52 · see citing works
Relationships Between 24-Hour Urinary Free Cortisol Concentrations and Metabolic Syndrome in Obese Children
Reinehr, T., Kulle, A. E., Wolters, B., Knop, C., Lass, N., Welzel, M., & Holterhus, P. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4398 · Cited by 50 · see citing works
Chronic administration of ellagic acid improved the cognition in middle-aged overweight men
Liu, Y., Yu, S., Wang, F., Yu, H., Li, X., Dong, W.-R., Lin, R., & Liu, Q. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0583 · Cited by 45 · see citing works
N-Acetylcysteine Supplementation Decreases Osteoclast Differentiation and Increases Bone Mass in Mice Fed a High-Fat Diet
Cao, J., & Picklo, M. J. (2013) · Journal of Nutrition · doi:10.3945/jn.113.185397 · Cited by 43 · see citing works
Effects of adrenal hormones on the expression of adiponectin and adiponectin receptors in adipose tissue, muscle and liver
de Oliveira, C., Iwanaga-Carvalho, C., Mota, J. F., Oyama, L. M., Ribeiro, E. B., & do Nascimento, C. M. O. (2011) · Steroids · doi:10.1016/j.steroids.2011.06.004 · Cited by 32 · see citing works
Interleukin-1 Antagonism Decreases Cortisol Levels in Obese Individuals
Urwyler, S. A., Schüetz, P., Ebrahimi, F., Donath, M. Y., & Christ‐Crain, M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3931 · Cited by 29 · see citing works
Effects of High Fat Diet on the Basal Activity of the Hypothalamus-Pituitary-Adrenal Axis in Mice: A Systematic Review
Auvinen, A. P., Romijn, J. A., Biermasz, N. R., Havekes, L. M., Smit, J. W. A., Rensen, P. C. N., & Pereira, A. M. (2011) · Hormone and Metabolic Research · doi:10.1055/s-0031-1291305 · Cited by 27 · see citing works
Nutritional and Hormonal Modulation of Adiponectin and its Receptors adipoR1 and adipoR2
de Oliveira, C., de Mattos, A. B. M., Silva, C. B. R., Mota, J. F., & Zemdegs, J. C. S. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-398313-8.00003-8 · Cited by 23 · see citing works
An overview of the contribution of fatness and fitness factors, and the role of exercise, in the formation of health status for individuals who are overweight
Clark, J. E. (2012) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-11-19 · Cited by 19 · see citing works
Family conflict and lower morning cortisol in adolescents and adults: modulation of puberty
Zhang, J., Lam, S.-P., Kong, A. P. S., Ronald, C. W., Li, S. X., Chan, J. W. Y., Yu, M. W., Zhou, J., Chan, M. H. M., Ho, C. S., et al. (2016) · Scientific Reports · doi:10.1038/srep22531 · Cited by 12 · see citing works
Comparison of 1 mg versus 2 mg Dexamethasone Suppression Test in Patients with Obesity
Urwyler, S. A., Cupa, N., & Christ‐Crain, M. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-119128 · Cited by 10 · see citing works
Enzymatic intracrine regulation of white adipose tissue
DiSilvestro, D. J., Petrosino, J. M., Aldoori, A., Melgar-Bermudez, E., Wells, A., & Ziouzenkova, O. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0019 · Cited by 10 · see citing works
Role of metabolic dysfunction in treatment resistance of major depressive disorder
Toups, M. S., & Trivedi, M. H. (2011) · Neuropsychiatry · doi:10.2217/npy.11.49 · Cited by 9 · see citing works
Associations between weight-related eating behaviors and adiposity in postmenopausal Japanese American and white women
Schembre, S. M., Albright, C. L., Lim, U., Wilkens, L. R., Murphy, S. P., Novotny, R., Ernst, T. M., Chang, L., Kolonel, L. N., & Marchand, L. L. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.04.027 · Cited by 7 · see citing works
The Association of Cortisol Excretion with Weight and Metabolic Parameters in Nondiabetic Patients with Morbid Obesity
Brix, J. M., Tura, A., Herz, C. T., Feder, A., Krzizek, E.-C., Parzer, V., Pacini, G., & Ludvik, B. H. (2021) · Obesity Facts · doi:10.1159/000517766 · Cited by 6 · see citing works
Interleukin-1 antagonism decreases cortisol levels in obese individuals
Urwyler, S. A., Schütz, P., Ebrahimi, F., Donath, M. Y., & Christ‐Crain, M. (2017) · Endocrine Abstracts · doi:10.1530/endoabs.49.oc11.3 · Cited by 5 · see citing works
Corticosteroid-binding Globulin, Cortisol, Free Cortisol, and Sex Hormone-binding Globulin Responses Following Oral Glucose Challenge in Spinal Cord-injured and Able-bodied Men
Lewis, J., Jones, L., Legge, M., & Elder, P. (2010) · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · doi:10.1055/s-0030-1265128
Counselors Within the Chronic Care Model: Supporting Weight Management
Sheesley, A. P. (2016) · Journal of Counseling & Development · doi:10.1002/jcad.12079 · Cited by 3 · see citing works
Diet, Lifestyle, and AGA/FPHL
Anastassakis, K. (2022) · Springer eBooks · doi:10.1007/978-3-031-08057-9_26 · Cited by 2 · see citing works
Sleep Disorders and Cancer Risk
Thompson, C. L., & Li, L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9527-7_8 · Cited by 1 · see citing works
POTENTIAL EFFECT OF PLATELET RICH PLASMA AS A PROMOTER OF BONE HEALING IN OBESE RATS (HISTOLOGICAL AND ULTRASTRUCTURAL STUDY)
Labah, D. A., & Wahba, O. M. (2023) · Egyptian Dental Journal /Egyptian Dental Journal · doi:10.21608/edj.2022.171428.2328 · Cited by 1 · see citing works
Antenatal determinants of child lung development
Holden, K. A., Gibson, M., Sinha, I. P., & Hawcutt, D. B. (2023) · European Respiratory Society eBooks · doi:10.1183/2312508x.10016222 · Cited by 1 · see citing works
Adrenal Function and Obesity
Proietti-Pannunzi, L., Motta, C., & Toscano, V. (2014) · Springer eBooks · doi:10.1007/978-3-319-09045-0_6
Obesity induced dysfunction of gastric vagal afferent signalling.
Kentish, S. J. (2013) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Факторы и состояния, влияющие на секрецию и функцию транскортина плазмы крови
Шевэ, А. Л., Бельцевич, Д. Г., Гаджиева, К. Ш., Багирова, Х. В., Эбзеева, А. К., Романова, А. Н., Гаджимурадова, М. М., & Мельниченко, Г. А. (2025) · Problemy Endokrinologii · doi:10.14341/probl13483
Polycystic ovary syndrome - Effect of acupuncture on insulin resistance and neuroendocrine function
Johansson, J. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Cortisol secretion in obesity.
Kartaleva, M., & Maleeva, A. (1989) · PubMed
[Aspects of cortisol metabolism in obesity].
Balestreri, R., Jacopino, G. E., Foppiani, E., & Elicio, N. (1968) · PubMed
[Studies on the secretion and metabolism of cortisol in obesity and Cushing's disease].
Cassano, C., Scavo, D., & Jacobelli, A. (1968) · PubMed · Cited by 1 · see citing works
CORTISOL SECRETION RATE AND URINARY CORTICOID EXCRETION IN NORMAL AND OBESE SUBJECTS
Copinschi, G., Cornil, A., Leclercq, R., & Franckson, J. R. M. (1966) · European Journal of Endocrinology · doi:10.1530/acta.0.0510186 · Cited by 17 · see citing works
Urinary free cortisone, but not cortisol, is associated with urine volume in severe obesity
Müssig, K., Remer, T., Fritsche, A., Häring, H., & Maser‐Gluth, C. (2009) · Steroids · doi:10.1016/j.steroids.2009.03.007 · Cited by 8 · see citing works
Self-citation

Authors: Müssig, K., Remer, T., & Maser-Gluth, C.
Affiliations: Universitätsklinikum Tübingen (DE)
Forschungsinstitut für Kinderernährung (DE)
Corresponding author: Müssig, Karsten
ORCID: Müssig, Karsten
Remer, Thomas
Venue: The Journal of Steroid Biochemistry and Molecular Biology
Publisher: Elsevier BV
Published: 2010-08
Volume: 121
Issue: 3-5
Pages: 589-593
ISSN: 0960-0760 (ISSN-L)
DOI: 10.1016/j.jsbmb.2010.01.008
OpenAlex: W2056800974
Cited by: 36
References: 66
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 8 · 2012: 5
FWCI: 0.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: obesity, cortisol, urinary cortisol metabolites, cortisol metabolism, visceral fat, body size, confounding factors
MeSH terms: Humans, Hydrocortisone, Obesity, Stress, Psychological, Intra-Abdominal Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brief review: Glucocorticoid excretion in obesity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks