Human 17β-Hydroxysteroid Dehydrogenase Type 2 Messenger Ribonucleic Acid Expression and Localization in Term Placenta and in Endometrium during the Menstrual Cycle1
Abstract
According to the current hypothesis, 17beta-hydroxysteroid dehydrogenases (17HSDs) regulate the extent of estrogen influence in the endometrium by converting estradiol (E2) locally into a biologically less active sex steroid, estrone (E1), and vice versa. Recently, we have shown that both 17HSD type 1 and type 2 are expressed in the human endometrium, and in the present work, using in situ hybridization, we show that 17HSD type 2 is localized in the glandular epithelial cells as previously shown for the type 1 enzyme, but in contrast to type 1, the expression of type 2 is highest at the end of the cycle. Hence, we hypothesize that the differential expression of the two 17HSD enzymes, with opposite activities in same cell types, could modulate intracellular E2 concentrations during the end of the luteal phase of the menstrual cycle. We further analyzed the expression of 17HSD type 1 and type 2 mRNAs in term human placenta. Expression of 17HSD type 1 mRNA was detected in the syncytiotrophoblasts, and signals for type 2 mRNA were found inside the villi, corresponding to cytotrophoblasts. The expression of 17HSD type 2 in the placenta may serve to maintain the presence of inactive sex steroids and attenuate the formation of biologically potent androgens and estrogens.
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Expression of HSD17B2 is increased by progesterone and elevated in the secretory phase.
“Expression of HSD17B2 is increased by progesterone and elevated in the secretory phase [4,45].”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [45]
The predominant isoform with oxidative 17β-HSD activity in the endometrium is HSD17B2, which converts active T to A4.
“The predominant isoform with oxidative 17β-HSD activity in the endometrium is HSD17B2, which converts active T to A4.”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [45]
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“Expression of HSD17B2 is increased by progesterone and elevated in the secretory phase [4,45].”
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17β-hydroxysteroid dehydrogenases in human endometrium and its disorders
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- Authors
- Mustonen, M. V. J., Isomaa, V. V., Vaskivuo, T., Tapanainen, J., Poutanen, M. H., Stenbäck, F., Vihko, R. K., & Vihko, P. T.
- Affiliations
- World Health Organization (CH)
- University of Oulu (FI)
- Corresponding author
- Vihko, Pirkko T.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-04
- Volume
- 83
- Issue
- 4
- Pages
- 1319-1324
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2050194681
- Cited by
- 84
- References
- 6
- Citations by year
- 2024: 1 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 3 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- 17β-hydroxysteroid dehydrogenase type 2, 17β-hydroxysteroid dehydrogenase type 1, term placenta, endometrium, menstrual cycle, estradiol, estrone, syncytiotrophoblast, cytotrophoblast, luteal phase, gene expression, mRNA localization
- MeSH terms
- Cell Division, Endometrium, Epithelial Cells, Female, Humans, Intestine, Small, Labor, Obstetric, Menstrual Cycle, Placenta, Pregnancy, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases, In Situ Hybridization
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