The Analyses of 17β-Hydroxysteroid Dehydrogenase Isozymes in Human Endometrial Hyperplasia and Carcinoma1
Abstract
Intratumoral metabolism and synthesis of estrogens are considered to play very important roles in the pathogenesis and development of human endometrial adenocarcinoma. The 17beta-hydroxysteroid dehydrogenase (17beta-HSD) isozymes catalyze the interconversion of estradiol (E2) and estrone and thereby serve to modulate the tissue levels of bioactive E2. To elucidate the possible involvement of this enzyme in human endometrial carcinoma, we first examined the expression of 17beta-HSD type 1 and type 2 in 20 normal cycling human endometria, 36 endometrial hyperplasia, and 46 endometrial endometrioid adenocarcinoma using immunohistochemistry, and we then studied immunoreactivity of 17beta-HSD type 2 using immunoblotting analyses, the activity of 17beta-HSD type 1 and type 2 using thin-layer chromatography and their expression using RT-PCR in endometrial endometrioid adenocarcinoma. We correlated these findings with various clinicopathological parameters to examine the biological significance of 17beta-HSDs in human endometrial disorders. 17beta-HSD type 2 immunoreactivity in normal endometrium was present in all cases of secretory phase (n = 14), but not in any endometrial mucosa of proliferative phase (n = 6). In addition, 17beta-HSD type 2 immunoreactivity was detected in 27 of 36 (75%) endometrial hyperplasia and 17 of 46 (37%) carcinoma cases. 17beta-HSD type 1 immunoreactivity was not detected in all the cases examined. In both endometrial hyperplasia and carcinoma cases there were significant positive correlations between 17beta-HSD type 2 and progesterone receptor labeling index (LI). In carcinoma cases, a significant inverse correlation was detected between 17beta-HSD type 2 immunoreactivity and age. In addition, 17beta-HSD type 2 immunoreactivity was also correlated with 17beta-HSD type 2 enzymatic activity, and semiquantitative analyses of 17beta-HSD type 2 messenger RNA. No significant correlations were detected between 17beta-HSD type 2 and estrogen receptor LI, Ki67 LI, amount of aromatase messenger RNA or histological grade. These data indicated that the expression of 17beta-HSD type 2 in hyperplastic and/or neoplastic endometrium may represent altered cellular features through hyperplastic and neoplastic transformation. However, 17beta-HSD type 2 may also play some protective and/or suppressive roles toward unopposed estrogenic effects through inactivating E2 in situ, especially in premenopausal patients.
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Increased immunoexpression of aromatase, STS and 17βHSD enzymes has been reported in endometrial hyperplasia and endometrial cancer.
“Sasano and collaborators have developed novel antibodies and reported evidence of increased immunoexpression of aromatase [81], STS [82] and 17βHSD enzymes [83] in endometrial hyperplasia and EC.”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [83]
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Parker, S. L., Tong, T., Bolden, S., & Wingo, P. A. (1996) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.46.1.5 · Cited by 1,757 · see citing works
Effects of estrogen on memory function in surgically menopausal women
Phillips, S. M. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90007-t · Cited by 746 · see citing works
PTEN/MMAC1 mutations in endometrial cancers.
Risinger, J. I., Hayes, A. K., Berchuck, A., & Barrett, J. C. (1997) · PubMed · Cited by 509 · see citing works
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480 · see citing works
Wu, L., Einstein, M., Geissler, W. M., Chan, H. K., Elliston, K. O., & Andersson, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31480-7 · Cited by 437 · see citing works
Randall, T. C., & Kurman, R. J. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00297-4 · Cited by 432 · see citing works
The epidemiology of endometrial cancer
Parazzini, F., Vecchia, C. L., Bocciolone, L., & Franceschi, S. (1991) · Gynecologic Oncology · doi:10.1016/0090-8258(91)90246-2 · Cited by 398 · see citing works
Zeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Andersson, S., Johns, A., Meng, L., Putman, M., Carr, B., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5301 · Cited by 308 · see citing works
Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA
Peltoketo, H., Isomaa, V., Mäentausta, O., & Vihko, R. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80548-9 · Cited by 294 · see citing works
The, V. L., Labrie, C., Zhao, H. F., Couët, J., Lachance, Y., Simard, J., Leblanc, G., Côté, J., Bérubé, D., Gagné, R., et al. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1301 · Cited by 274 · see citing works
A CASE-CONTROL STUDY OF CANCER OF THE ENDOMETRIUM
KELSEY, J. L., LiVolsi, V. A., Holford, T. R., FISCHER, D. B., Mostow, E. D., Schwartz, P. E., O’Connor, T., & White, C. (1982) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113417 · Cited by 263 · see citing works
Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma
Inoue, K., Ozeki, Y., Suganuma, T., Sugiura, Y., & Tanaka, S. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970115)79:2 · Cited by 254 · see citing works
Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.
Maxwell, G. L., Risinger, J. I., Gumbs, C. E., Shaw, H., Bentley, R. C., Barrett, J. C., Berchuck, A., & Futreal, P. A. (1998) · PubMed · Cited by 231 · see citing works
The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia
Ferenczy, A. S., & Gelfand, M. M. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90103-8 · Cited by 224 · see citing works
Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies
Sasano, H., & Harada, N. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0342 · Cited by 223 · see citing works
Self-citationCauses and consequences of microsatellite instability in endometrial carcinoma.
Gurin, C. C., Federici, M. G., Kang, L., & Boyd, J. A. (1999) · PubMed · Cited by 215 · see citing works
Casey, M. L., MacDonald, P. C., & Andersson, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117569 · Cited by 212 · see citing works
MIETTINEN, M. M., MUSTONEN, M. V. J., POUTANEN, M. H., ISOMAA, V. V., & VIHKO, R. K. (1996) · Biochemical Journal · doi:10.1042/bj3140839 · Cited by 188 · see citing works
Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.
Sasaki, H., Nishii, H., Takahashi, H., Tada, A., Furusato, M., Terashima, Y., Siegal, G. P., Parker, S. L., Kohler, M. F., & Berchuck, A. (1993) · PubMed · Cited by 176 · see citing works
Suzuki, T., Sasano, H., Kimura, N., Midori, T., Fukaya, T., Yajima, A., & Nagura, H. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138757 · Cited by 175 · see citing works
Self-citationAromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma.
Sasano, H., Frost, A. R., Saitoh, R., Harada, N., Poutanen, M., Vihko, R., Bulun, S. E., Silverberg, S. G., & Nagura, H. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923858 · Cited by 167 · see citing works
Self-citationHarada, N., & Yamada, K. (1992) · Endocrinology · doi:10.1210/endo.131.5.1425429 · Cited by 120 · see citing works
Self-citationPOUTANEN, M. H., ISOMAA, V. V., Lehto, V. P., & Vihko, R. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910500310 · Cited by 116 · see citing works
Serum androgens and estrogens in postmenopausal women with and without endometrial cancer
Judd, H. L., Davidson, B. J., Frumar, A. M., Shamonki, I. M., Lagasse, L. D., & Ballon, S. C. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)91043-1 · Cited by 114 · see citing works
Presence of alternatively spliced transcripts of aromatase gene in human breast cancer
Utsumi, T., Harada, N., MARUTA, M., & Takagi, Y. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.6.8964875 · Cited by 113 · see citing works
Self-citationPollow, K., LÜBBERT, H., BOQUOI, E., Kreuzer, G., & Pollow, B. (1975) · Endocrinology · doi:10.1210/endo-96-2-319 · Cited by 109 · see citing works
ESTROGEN SYNTHESIS IN NORMAL AND MALIGNANT HUMAN ENDOMETRIUM
Tseng, L., Mazella, J., Mann, W. J., & Chumas, J. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-5-1029 · Cited by 103 · see citing works
Cellular Localization of Orexin Receptors in Human Pituitary
Blanco, M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.4.1616 · Cited by 95 · see citing works
In vivoutilization of substrate by human sarcoma-bearing limbs
Norton, J. A., BURT, M. E., & Brennan, M. F. (1980) · Cancer · doi:10.1002/1097-0142(19800615)45:12 · Cited by 86 · see citing works
Pc, M., Grodin, J. M., Edman, C. D., Vellios, F., & Siiteri, P. K. (1976) · PubMed · Cited by 84 · see citing works
Mutations of the Ki-ras oncogene in carcinoma of the endometrium.
Caduff, R. F., Johnston, C. M., & Frank, T. S. (1995) · Europe PMC (PubMed Central) · Cited by 84 · see citing works
Mustonen, M. V. J., Isomaa, V. V., Vaskivuo, T., Tapanainen, J., Poutanen, M. H., Stenbäck, F., Vihko, R. K., & Vihko, P. T. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4709 · Cited by 84 · see citing works
A case-control study of uterine endometrial cancer of pre- and post-menopausal women.
Niwa, K., Imai, A., Hashimoto, M., Yokoyama, Y., Mori, H., Matsuda, Y., & Tamaya, T. (2000) · Oncology Reports · doi:10.3892/or.7.1.89 · Cited by 66 · see citing works
Endogenous steroids in the pathophysiology of breast cancer
Vihko, R., Apter, D. L., & Bulbrook, R. D. (1989) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(89)80012-5 · Cited by 64 · see citing works
Effects of hormone therapy on the endometrium.
Deligdisch, L. (1993) · PubMed · Cited by 61 · see citing works
Aromatization of androstenedione by normal and neoplastic endometrium of the uterus
Junko, Y., Yamamoto, T., & Hiroji, O. (1985) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(85)90142-6 · Cited by 55 · see citing works
Takeyama, J., Sasano, H., Suzuki, T., Iinuma, K., Nagura, H., & Andersson, S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5212 · Cited by 54 · see citing works
Self-citationBiological markers for breast carcinoma
Waalkes, T. P., Enterline, J. P., Shaper, J. H., Abeloff, M. D., & Ettinger, D. S. (1984) · Cancer · doi:10.1002/1097-0142(19840201)53:3+ · Cited by 49 · see citing works
Gast, M. J., Sims, H. F., Murdock, G. L., Gast, P. M., & Strauss, A. W. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90958-7 · Cited by 45 · see citing works
Inhibitory Effects of Medroxyprogesterone Acetate on Mouse Endometrial Carcinogenesis
Niwa, K., Morishita, S., Murase, T., Itoh, N., Tanaka, T., Mori, H., & Tamaya, T. (1995) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1995.tb02460.x · Cited by 15 · see citing works
Niwa, K., Morishita, S., Hashimoto, M., Yokoyama, Y., & Tamaya, T. (1997) · International Journal of Clinical Oncology · doi:10.1007/bf02490129 · Cited by 14 · see citing works
End results in 400 cases of placenta previa
Aldridge, A. H., & Parks, T. J. (1938) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(38)90578-2 · Cited by 4 · see citing works
Flagged first, then by citations
4 of the 47 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Role of nuclear progesterone receptor isoforms in uterine pathophysiology
Patel, B., Elguero, S., Thakore, S., Dahoud, W., Bedaiwy, M., & Mesiano, S. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmu056 · Cited by 353 · see citing works
AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
Rižner, T. L., Šmuc, T., Rupreht, R., Šinkovec, J., & Penning, T. M. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.009 · Cited by 159 · see citing works
Estrogen metabolizing enzymes in endometrium and endometriosis
Dassen, H., Punyadeera, C., Kamps, R., Delvoux, B., Van Langendonckt, A., Donnez, J., Husen, B., Thole, H., Dunselman, G., & Groothuis, P. (2007) · Human Reproduction · doi:10.1093/humrep/dem310 · Cited by 141 · see citing works
Oestrogen and progesterone regulation of inflammatory processes in the human endometrium
King, A. E., & Critchley, H. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.01.003 · Cited by 129 · see citing works
Ito, K., Utsunomiya, H., Yaegashi, N., & Sasano, H. (2007) · Endocrine Journal · doi:10.1507/endocrj.kr-114 · Cited by 122 · see citing works
Self-citationSteroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma
Utsunomiya, H., Ito, K., Suzuki, T., Kitamura, T., Kaneko, C., Nakata, T., Niikura, H., Okamura, K., Yaegashi, N., & Sasano, H. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0040 · Cited by 85 · see citing works
Self-citationAndrogens, oestrogens and endometrium: a fine balance between perfection and pathology
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0106 · Cited by 76 · see citing works
Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer
Rižner, T. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.026 · Cited by 75 · see citing works
Lépine, J., Audet‐Walsh, É., Grégoire, J., Têtu, B., Plante, M., Ménard, V., Ayotte, P., Brisson, J., Caron, P., Villeneuve, L., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2648 · Cited by 75 · see citing works
Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103276 · Cited by 70 · see citing works
“Sasano and collaborators have developed novel antibodies and reported evidence of increased immunoexpression of aromatase [81], STS [82] and 17βHSD enzymes [83] in endometrial hyperplasia and EC.”
BackgroundCollins, F., Macpherson, S., Brown, P., Bombail, V., Williams, A. R. W., Anderson, R. A., Jabbour, H. N., & Saunders, P. T. K. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-330 · Cited by 70 · see citing works
Konings, G. F. J., Brentjens, L. S., Delvoux, B., Linnanen, T., Cornel, K. M. C., Koskimies, P., Bongers, M. Y., Kruitwagen, R. F. P. M., Xanthoulea, S., & Romano, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00940 · Cited by 65 · see citing works
17β-hydroxysteroid dehydrogenases in human endometrium and its disorders
Ito, K., Utsunomiya, H., Suzuki, T., Saitou, S., Akahira, J.-I., Okamura, K., Yaegashi, N., & Sasano, H. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.038 · Cited by 54 · see citing works
Self-citationTsuchiya, M., Nakao, H., Katoh, T., Sasaki, H., Hiroshima, M., Tanaka, T., Matsunaga, T., Hanaoka, T., Tsugane, S., & Ikenoue, T. (2005) · Human Reproduction · doi:10.1093/humrep/deh726 · Cited by 52 · see citing works
Segawa, T., Shozu, M., Murakami, K., Kasai, T., Shinohara, K., Nomura, K., Ohno, S., & Inoue, M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1859 · Cited by 52 · see citing works
Pluchino, N., Mamillapalli, R., Wenger, J., Ramyead, L., Drakopoulos, P., Tille, J., & Taylor, H. S. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.01.036 · Cited by 48 · see citing works
Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers
Bukato, K., Kostrzewa, T., Marino, A., Górska‐Ponikowska, M., & Sawicki, S. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01583-0 · Cited by 48 · see citing works
Ito, K. (2007) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.212.1 · Cited by 45 · see citing works
Self-citationUtsunomiya, H., Suzuki, T., Ito, K., Moriya, T., Konno, R., Sato, S., Yaegashi, N., Okamura, K., & Sasano, H. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01766.x · Cited by 44 · see citing works
Self-citationSaloniemi, T., Järvensivu, P., Koskimies, P., Jokela, H., Lamminen, T., Ghaem‐Maghami, S., Dina, R. E., Damdimopoulou, P., Mäkelä, S., Perheentupa, A. H., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090325 · Cited by 40 · see citing works
Sinreih, M., Hevir, N., & Rižner, T. L. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.11.012 · Cited by 38 · see citing works
Local estrogen metabolism (intracrinology) in endometrial cancer: A systematic review
Cornel, K. M. C., Bongers, M. Y., Kruitwagen, R. F. P. M., & Romano, A. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.10.004 · Cited by 37 · see citing works
Estrogen-Metabolizing Enzymes in Breast Cancers from Women over the Age of 80 Years
Honma, N., Takubo, K., Sawabe, M., Arai, T., Akiyama, F., Sakamoto, G., Utsumi, T., Yoshimura, N., & Harada, N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1967 · Cited by 37 · see citing works
Self-citationAssociation of estrogen with glucocorticoid levels in visceral fat in postmenopausal women
Yamatani, H., Takahashi, K., Yoshida, T., Takata, K., & Kurachi, H. (2013) · Menopause · doi:10.1097/gme.0b013e318271a640 · Cited by 34 · see citing works
Kasai, T., Shozu, M., Murakami, K., Segawa, T., Shinohara, K., Nomura, K., & Inoue, M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032085 · Cited by 34 · see citing works
The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer
Sinreih, M., Knific, T., Anko, M., Hevir, N., Vouk, K., Jerin, A., Frković Grazio, S., & Rižner, T. L. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00368 · Cited by 33 · see citing works
Ito, K., Utsunomiya, H., Niikura, H., Yaegashi, N., & Sasano, H. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.023 · Cited by 33 · see citing works
Self-citationExpression analysis of estrogen-metabolizing enzymes in human endometrial cancer
Šmuc, T., Rupreht, R. R., Šinkovec, J., Adamski, J., & Rižner, T. L. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.013 · Cited by 33 · see citing works
Lahav‐Baratz, S. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah084 · Cited by 31 · see citing works
Ito, K., Miki, Y., Suzuki, T., McNamara, K. M., & Sasano, H. (2016) · Endocrine-Related Cancer · doi:10.1530/erc-15-0470 · Cited by 29 · see citing works
Self-citation(2010) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
14-3-3σ in Endometrial Cancer–A Possible Prognostic Marker in Early-Stage Cancer
Ito, K., Suzuki, T., Akahira, J., Sakuma, M., Saitou, S., Okamoto, S., Niikura, H., Okamura, K., Yaegashi, N., Sasano, H., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0187 · Cited by 28 · see citing works
Self-citationShiga, N., Utsunomiya, H., Miki, Y., Nagase, S., Kobayashi, R., Matsumoto, M., Niikura, H., Ito, K., & Yaegashi, N. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1013 · Cited by 26 · see citing works
Self-citationOrphan nuclear receptor DAX‐1 in human endometrium and its disorders
Saito, S., Ito, K., Suzuki, T., Utsunomiya, H., Akahira, J., Sugihashi, Y., Niikura, H., Okamura, K., Yaegashi, N., & Sasano, H. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00101.x · Cited by 23 · see citing works
Self-citationImmunohistochemical Markers in Endometrial Hyperplasia: Is There a Panel With Promise?
Allison, K. H., Tenpenny, E., Reed, S. D., Swisher, E. M., & Garica, R. L. (2008) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0b013e318159b88e · Cited by 23 · see citing works
STAR and AKR1B10 are down-regulated in high-grade endometrial cancer
Sinreih, M., Štupar, S., Čemažar, L., Verdenik, I., Grazio, S. F., Smrkolj, Š., & Rižner, T. L. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.02.015 · Cited by 21 · see citing works
Hashimoto, C., Miki, Y., Tanaka, S., Takagi, K., Fue, M., Do.e, Z., Li, B., Yaegashi, N., Suzuki, T., & Ito, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041139 · Cited by 22 · see citing works
Self-citationInteraction of soy and 17β-HSD1 gene polymorphisms in the risk of endometrial cancer
Dai, Q., Xu, W., Long, J., Courtney, R., Xiang, Y., Cai, Q., Cheng, J., Zheng, W., & Shu, X. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32801112a1 · Cited by 18 · see citing works
(PPR), E. P. O. P. P. P. A. T. R., Hernández, A. F., Adriaanse, P., Aldrich, A., Berny, P. J., Čoja, T., Duquesne, S., Focks, A., Millet, M., Pelkonen, O., et al. (2023) · EFSA Journal · doi:10.2903/j.efsa.2023.7744 · Cited by 16 · see citing works
Pluchino, N., Poppi, G., Yart, L., Marci, R., Wenger, J., Tille, J., & Cohen, M. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14372 · Cited by 16 · see citing works
da Costa, K. D. A., Malvezzi, H., Dobo, C., Neme, R. M., Filippi, R. Z., Aloia, T. P. A., Prado, E. R., Meola, J., & Piccinato, C. D. A. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.854991 · Cited by 15 · see citing works
Brucker, S. Y., Eisenbeis, S., König, J., Lamy, M., Salker, M. S., Zeng, N., Seeger, H., Henes, M., Schöller, D., Schönfisch, B., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000464116 · Cited by 15 · see citing works
Nagayoshi, Y., Ohba, T., Yamamoto, H., Miyahara, Y., Tashiro, H., Katabuchi, H., & Okamura, H. (2005) · Molecular Human Reproduction · doi:10.1093/molehr/gah215 · Cited by 12 · see citing works
SULFATION PATHWAYS: Contribution of intracrine oestrogens to the aetiology of endometriosis
Piccinato, C. D. A., Malvezzi, H., Gibson, D. A., & Saunders, P. T. K. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0297 · Cited by 12 · see citing works
Rotinen, M., Villar, J., & Encı́o, I. (2012) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0155-1 · Cited by 10 · see citing works
Keleş, E., Lianeri, M., & Jagodziński, P. P. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0441-3 · Cited by 8 · see citing works
Dahmoun, M. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.10.021 · Cited by 8 · see citing works
The Role of Steroid Sulfatase as a Prognostic Factor in Patients with Endometrial Cancer
Lee, W. M., Jang, K.-S., Bae, J., & Koh, A. R. (2016) · Yonsei Medical Journal · doi:10.3349/ymj.2016.57.3.754 · Cited by 7 · see citing works
Epidemiology of Uterine Corpus Cancers
Brinton, L. A., Lacey, J. V., Devesa, S. S., & Sherman, M. E. (2004) · Elsevier eBooks · doi:10.1016/b978-0-443-07142-3.50018-x · Cited by 6 · see citing works
Uterine response to estradiol under action of chorionic gonadotropin in mice
Gunin, A. G., Emelianov, V. U., Mironkin, I. U., Morozov, M. P., & Ivanov, V. A. (2003) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.2003.13323.x · Cited by 4 · see citing works
Pasqualini, J., & Chetrite, G. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.027 · Cited by 3 · see citing works
Sex Steroids and Endometriosis
Kitawaki, J. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_10
Apoptosis, proliferation, and sex steroid receptors in endometrium and endometrial carcinoma
Dahmoun, M. (2003) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Firnhaber, S. (2007) · DuEPublico (University of Duisburg-Essen)
Romano, A., Dunselman, G. A. J., Evers, J. L. H., & Kruitwagen, R. F. P. M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.023
Ito, K., Utsunomiya, H., Niikura, H., Yaegashi, N., & Sasano, H. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.024
Self-citationGynecological Malignancies and Diet in Menopause: From the Biological and Epidemiological Viewpoints
Ito, K., Sasano, H., & Yaegashi, N. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-373-2_24
Self-citation
- Authors
- Utsunomiya, H., Suzuki, T., Kaneko, C., Takeyama, J., Nakamura, J., Kimura, K., Yoshihama, M., Harada, N., Ito, K., Konno, R., Sato, S., Okamura, K., & Sasano, H.
- Affiliations
- Tohoku University (JP)
- Megmilk Snow Brand (Japan) (JP)
- Fujita Health University (JP)
- Corresponding author
- Utsunomiya, Hiroki
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2001-07
- Volume
- 86
- Issue
- 7
- Pages
- 3436-3443
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2116219667
- Cited by
- 57
- References
- 47
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (11470047)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- 17β-hydroxysteroid dehydrogenase, endometrial hyperplasia, endometrial adenocarcinoma, endometrioid carcinoma, estrogen metabolism, estradiol, estrone, progesterone receptor, estrogen receptor, endometrial cycle
- MeSH terms
- Adenocarcinoma, Endometrial Hyperplasia, Female, Humans, Immunohistochemistry, Isoenzymes, Menstrual Cycle, Receptors, Progesterone, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases, Immunoblotting, Gene Expression, Endometrial Neoplasms, Reverse Transcriptase Polymerase Chain Reaction
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