Exaggerated Adrenarche and Hyperinsulinism in Adolescent Girls Born Small for Gestational Age
Abstract
Serum dehydroepiandrosterone-sulfate (DHEAS) is a classic marker for adrenarche and, subsequently, for the individual hormonal milieu. We have tested the hypothesis that prenatal growth reduction is followed by exaggerated adrenarche. Serum DHEAS, androstenedione and insulin concentrations were determined together with fasting glycemia in matched populations of asymptomatic, non-obese, post-menarcheal girls (mean age 14 yr) who were born either with a strictly appropriate weight for gestational age (AGA) or small for gestational age (SGA). When compared to AGA girls, the SGA girls had identical glucose levels, higher values for insulin and androstenedione (p<0.01), and a two-fold rise of DHEAS concentrations (p<0.0001). In conclusion, girls with prenatal growth reduction were found to be prone to develop, besides hyperinsulinism, a variant of exaggerated adrenarche. It remains to be verified whether the exaggerated adrenarche in adolescence is followed by adrenal hyperandrogenism throughout adulthood and senescence.
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When molecular genetic testing is performed, mutations on both CYP21A2 alleles are usually identified when the stimulated 17-hydroxyprogesterone exceeds 1,500 ng/dl.
“When molecular genetic testing is performed, mutations on both CYP21A2 alleles are usually identified found when the stimulated 17-OHP exceeds 1,500 ng/dl [107]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [107]
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Self-citation
- Authors
- Ibáñez, L., Potau, N., Marcos, M. V., & de Zegher, F.
- Affiliations
- Hospital Sant Joan de Déu Barcelona (ES)
- Universitat Autònoma de Barcelona (ES)
- ORCID
- Ibáñez, Lourdes
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1999-12
- Volume
- 84
- Issue
- 12
- Pages
- 4739-4741
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2077090372
- Cited by
- 211
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 9
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- hyperinsulinism, small for gestational age, adolescent girls, dehydroepiandrosterone sulfate, androstenedione, insulin, fasting blood glucose, fetal growth restriction, adrenal hyperandrogenism
- MeSH terms
- Adolescent, Adrenal Glands, Androstenedione, Birth Weight, Blood Glucose, Estradiol, Female, Humans, Hyperinsulinism, Infant, Newborn, Infant, Small for Gestational Age, Insulin, Menarche, Hyperandrogenism, Dehydroepiandrosterone Sulfate
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