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Cited by 106Ovarian function and disordersHypothalamic control of reproductive hormonesSexual Differentiation and Disorders

Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism

Ibáñez, Lourdes, Díaz, Rubén, López-Bermejo, Abel, Marcos, Maria Victoria·2009·Reviews in Endocrine and Metabolic Disorders
DOI 10.1007/s11154-008-9096-y
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Abstract

Premature pubarche-defined as the appearance of pubic hair before age 8 years in girls and 9 years in boys-has been traditionally considered a benign entity. However, recent evidence supports the notion that premature pubarche in girls may be a forerunner of the metabolic syndrome, and may precede the development of clinical ovarian androgen excess in adolescence. This sequence seems to occur more frequently when premature pubarche was preceded by reduced fetal growth and followed by excessive postnatal catch-up in height and particularly in weight; hyperinsulinemia appears to be a key factor in the development of this sequence of events. In girls with premature pubarche and a history of a low birth weight, puberty tends to start earlier and to have a faster course, so that final height may be moderately reduced. In these girls, metformin therapy may reverse the progression to clinical ovarian hyperandrogenism, normalize body composition and excess visceral fat, and delay pubertal progression without attenuating linear growth and bone mineralization, suggesting that adult height may be improved. Long-term follow-up of these patients is needed to fully determine the ultimate effects of insulin sensitization as well as the maintenance of these benefits after discontinuation of therapy.

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Crossref · 10.1007/s11154-008-9096-y

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  • For nonclassic congenital adrenal hyperplasia, ACTH-stimulated 17-hydroxyprogesterone values usually exceed 1,500-10,000 ng/dl.

    “For those with NCAH, ACTH-stimulated 17-OHP values usually exceed 1,500-10,000 ng/dl [106]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [106]

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Authors
Ibáñez, L., Díaz, R., López-Bermejo, A., & Marcos, M. V.
Affiliations
Hospital Sant Joan de Déu Barcelona (ES)
Corresponding author
Ibáñez, Lourdes
ORCID
Ibáñez, Lourdes
Venue
Reviews in Endocrine and Metabolic Disorders
Publisher
Springer Science and Business Media LLC
Published
2008-08-26
Volume
10
Issue
1
Pages
63-76
ISSN
  • 1389-9155 (ISSN-L)
  • 1573-2606
DOI
10.1007/s11154-008-9096-y
OpenAlex
W2072284140
Cited by
106
References
138
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 4 · 2013: 4 · 2012: 10
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Reviews in Endocrine and Metabolic Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
premature pubarche, metabolic syndrome, ovarian hyperandrogenism, polycystic ovary syndrome, hyperinsulinemia, catch-up growth, low birth weight, fetal growth restriction, metformin, insulin sensitization, pubertal timing, adult height, visceral fat, body composition, bone mineralization
MeSH terms
Blood Pressure, Body Composition, Body Height, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Insulin, Lipids, Polycystic Ovary Syndrome, Puberty, Puberty, Precocious, Hyperandrogenism, Metabolic Syndrome

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