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Cited by 288Ovarian function and disordersSexual Differentiation and DisordersGenetic and Kidney Cyst Diseases

Identifying Children at Risk for Polycystic Ovary Syndrome

Rosenfield, Robert L.·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2006-2012
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Abstract

CONTEXT: Polycystic ovary syndrome (PCOS) appears to arise as a complex trait with contributions from both heritable and nonheritable factors. Polygenic influences appear to account for about 70% of the variance in pathogenesis. In view of this evidence for congenital contributions to the syndrome, childhood manifestations may be expected. OBJECTIVE: The objective has been to review the evidence that risk factors for PCOS can be recognized in childhood. DESIGN: This study consisted of screening of the PCOS literature for articles pertaining to potential childhood and adolescent antecedents. RESULTS: Congenital virilizing disorders; above average or low birth weight for gestational age; premature adrenarche, particularly exaggerated adrenarche; atypical sexual precocity; or intractable obesity with acanthosis nigricans, metabolic syndrome, and pseudo-Cushing syndrome or pseudo-acromegaly in early childhood have been identified as independent prepubertal risk factors for the development of PCOS. During adolescence, PCOS may masquerade as physiological adolescent anovulation. Asymptomatic adolescents with a polycystic ovary occasionally (8%) have subclinical PCOS but often (42%) have a subclinical PCOS type of ovarian dysfunction, the prognosis for which is unclear. CONCLUSION: Identifying children at risk for PCOS offers the prospect of eventually preventing some of the long-term complications associated with this syndrome once our understanding of the basis of the disorder improves.

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  • Rapid postnatal catch-up growth and adiposity seem to increase the risk of excessive androgen secretion and precocious pubarche with a higher predilection to develop features suggestive of polycystic ovary syndrome in adolescence.

    “Rapid postnatal catch-up growth and adiposity seem to increase the risk of excessive androgen secretion and precocious pubarche with a higher predilection to develop features suggestive of PCOS in adolescence [4,140,141]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [4]

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Authors
Rosenfield, R. L.
Affiliations
University of Chicago (US)
Corresponding author
Rosenfield, Robert L.
ORCID
Rosenfield, Robert L.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-03
Volume
92
Issue
3
Pages
787-796
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2006-2012
OpenAlex
W2164180340
Cited by
288
References
121
Citations by year
2026: 5 · 2025: 11 · 2024: 12 · 2023: 9 · 2022: 10 · 2021: 15 · 2020: 13 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 11 · 2015: 15 · 2014: 14 · 2013: 26 · 2012: 19
FWCI
21.17
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (U54-041859)
  • National Center for Research Resources (RR 000055)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, childhood risk factors, premature adrenarche, birth weight, obesity, acanthosis nigricans, metabolic syndrome, ovarian dysfunction, PCOS prevention
MeSH terms
Adolescent, Anovulation, Child, Female, Humans, Hypothalamus, Models, Biological, Obesity, Ovary, Pituitary Gland, Polycystic Ovary Syndrome, Puberty, Precocious, Risk Factors, Adrenarche

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