Melatonin treatment for age-related insomnia

Zhdanova, Irina V.; Wurtman, Richard J.; Regan, Meredith M.; Taylor, Judith A.; Shi, Jian Ping; Leclair, Ojingwa U.

doi:10.1210/jcem.86.10.7901

Cited by 309Circadian rhythm and melatoninSleep and related disordersSleep and Work-Related Fatigue

Melatonin treatment for age-related insomnia

Zhdanova, Irina V., Wurtman, Richard J., Regan, Meredith M., Taylor, Judith A., Shi, Jian Ping, Leclair, Ojingwa U.·2001·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.86.10.7901

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Abstract

Older people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to younger people, in doses that raise their plasma melatonin levels to the nocturnal range, can accelerate sleep onset. We examined the ability of similar, physiological doses to restore nighttime melatonin levels and sleep efficiency in insomniac subjects over 50 yr old. In a double-blind, placebo-controlled study, subjects who slept normally (n = 15) or exhibited actigraphically confirmed decreases in sleep efficiency (n = 15) received, in randomized order, a placebo and three melatonin doses (0.1, 0.3, and 3.0 mg) orally 30 min before bedtime for a week. Treatments were separated by 1-wk washout periods. Sleep data were obtained by polysomnography on the last three nights of each treatment period. The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal. The pharmacologic dose (3.0 mg), like the lowest dose (0.1 mg), also improved sleep; however, it induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours. Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose.

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In Zhdanova et al., the low dose (0.1 mg) did not raise melatonin levels into the normal range.
“The low dose in the study did not raise melatonin levels into the normal range.”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [278]
In Zhdanova et al., the best objective data were found at 0.3 mg of melatonin.
“They found the best objective data at 0.3 mg of melatonin.”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [278]

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Authors: Zhdanova, I. V., Wurtman, R. J., Regan, M. M., Taylor, J. A., Shi, J. P., & Leclair, O. U.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Wurtman, Richard J.
ORCID: Zhdanova, Irina V.
Regan, Meredith M.
Taylor, Judith A.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2001-10
Volume: 86
Issue: 10
Pages: 4727-4730
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.86.10.7901
OpenAlex: W2097890124
Cited by: 308
References: 21
Citations by year: 2026: 9 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 16 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 11 · 2016: 9 · 2015: 7 · 2014: 23 · 2013: 16 · 2012: 13
FWCI: 4.87
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Massachusetts Institute of Technology
National Institutes of Health (1r01ag013667-01, RR 00088)
National Institute on Aging (R01 AG 13667)
National Center for Research Resources (MO1 RR-02172, M01RR002172, MO1-RR00088, M01RR000088)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: melatonin, sleep efficiency, plasma melatonin levels, older adults, nocturnal melatonin secretion, sleep onset, hypothermia, actigraphy
MeSH terms: Age Factors, Aged, Body Temperature, Double-Blind Method, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Melatonin, Middle Aged

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Melatonin treatment for age-related insomnia

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