Cited by 640Ovarian function and disordersAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

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Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome

Kelly, Chris C. J., Lyall, Helen, Petrie, John R., Gould, Gwyn W., Connell, John M. C., Sattar, Naveed·2001·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.86.6.7580

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Abstract

Low grade chronic inflammation as reflected by increased C-reactive protein (CRP) concentrations independently predicts those at risk for coronary heart disease (CHD) and type 2 diabetes. Women with polycystic ovarian syndrome (PCOS) are insulin resistant and have increased risk for CHD and type 2 diabetes, but currently there are no data on markers of inflammation in women with PCOS. Seventeen women with PCOS (defined on the basis of elevated testosterone and oligomenorrhea) and 15 healthy women matched as a group for body mass index were recruited. Measurement of CRP concentrations was made using a highly sensitive assay. Insulin resistance was assessed using the hyperinsulinemic euglycemic clamp technique. The women with PCOS had significantly elevated CRP concentrations relative to controls (geometric means, 2.12 and 0.67 mg/L, respectively; P = 0.016). Log CRP correlated with body mass index in both PCOS and controls (r = 0.58; P < 0.05 and r = 0.78; P < 0.01, respectively) and inversely with insulin sensitivity (r = -0.57; P < 0.05 and r = -0.69; P < 0.01). Total testosterone did not correlate with log CRP in either group. On adjustment for body mass index and age, there remained a significant difference in log CRP between PCOS and controls (t = 2.13; P < 0.05). On further adjustment for insulin sensitivity, log CRP was no longer significantly different between groups (t = 1.51; P = 0.14). We conclude that women with PCOS have significantly increased CRP concentrations relative to women with normal menstrual rhythm and normal androgen levels. We propose low grade chronic inflammation as a novel mechanism contributing to increased risk of CHD and type 2 diabetes in these women.

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Authors: Kelly, C. C. J., Lyall, H., Petrie, J. R., Gould, G. W., Connell, J. M. C., & Sattar, N.
Affiliations: University of Glasgow (GB)
Corresponding author: Sattar, Naveed
ORCID: Petrie, John R.
Gould, Gwyn W.
Sattar, Naveed
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2001-06
Volume: 86
Issue: 6
Pages: 2453-2455
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.86.6.7580
OpenAlex: W2168847507
Cited by: 640
References: 26
Citations by year: 2026: 22 · 2025: 26 · 2024: 21 · 2023: 32 · 2022: 25 · 2021: 41 · 2020: 28 · 2019: 22 · 2018: 20 · 2017: 19 · 2016: 20 · 2015: 19 · 2014: 28 · 2013: 21 · 2012: 35
FWCI: 18.68
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: polycystic ovary syndrome, low-grade inflammation, C-reactive protein, insulin resistance, coronary heart disease risk, type 2 diabetes risk, body mass index, hyperinsulinemic-euglycemic clamp, testosterone, women
MeSH terms: Adult, C-Reactive Protein, Chronic Disease, Female, Humans, Inflammation, Insulin Resistance, Osmolar Concentration, Polycystic Ovary Syndrome, Reference Values, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index

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Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome

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