Association between polycystic ovary syndrome and the risk of stroke and all-cause mortality: insights from a meta-analysis
Abstract
Many epidemiologic literatures have investigated the link between PCOS and long-term stroke risk and all-cause mortality, but the results are surprisingly conflicting. A meta-analysis was performed to examine the link between polycystic ovary syndrome (PCOS) and the risk of stroke, death from any cause, and assessed whether BMI might explain a higher risk of stroke. We searched the PUBMED, EMBASE, and Cochrane Library databases with no restrictions. Nine Cohort studies were identified, involving a total of 237,647 subjects. Compared with those without PCOS, subjects with PCOS were significantly associated with a increased risk of developing stroke (OR = 1.36; 95% CI 1.09-1.70; p = .007). However, no significant association was observed between PCOS and all-cause death (OR = 1.21; 95% CI 0.88-1.66; p = .25). Moreover, after pooling the five studies with risk estimates adjusted for BMI, the association between PCOS and stroke was slightly attenuated, although the odds ratios did not reach statistical significance (OR = 1.24; 95% CI 0.98-1.59). In conclusion, PCOS is associated with significant increased risk for stroke, while there is no consistent evidence to indicate that PCOS influences all-cause death outcomes. Increased BMI is an important contributor to the relationship between PCOS and stroke risk. Further study is needed to clarify which subgroups of subjects with the PCOS are at higher risk for stroke and should focus on developing reliable device for risk stratification.
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The increased risk of composite cardiovascular disease in women with polycystic ovary syndrome is maintained when examining stroke separately.
“This increased risk was maintained when examining ischaemic heart disease66 and stroke85 separately (supplementary table 3).”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [85]
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Mukherjee, S., Rai, D., Ghoshal, D., Chakraborty, T., & Karati, D. (2024) · Current Women s Health Reviews · doi:10.2174/0115734048268656231127064615 · Cited by 1 · see citing works
Emokpae, M. A., Van-lare, T. O., & Babatunde, E. M. (2024) · Fertility & Reproduction · doi:10.1142/s2661318224500208 · Cited by 3 · see citing works
Androgens and Cardiovascular Risk Factors in Polycystic Ovary Syndrome
Cardozo, L. L. Y., Huffman, A. M., Pruett, J. E., & Romero, D. G. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96005 · Cited by 1 · see citing works
Prevention of Cardiovascular Disease
Sharma, G. V., Minhas, A., & Michos, E. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819369-3.00013-7
Cardiovascular risk reduction in polycystic ovary syndrome
Shams, P., Ahmed, I., & Samad, Z. Z. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87932-3.00027-x
Syndrom polyzystischer Ovarien und kardiovaskuläres Risikoprofil
Bohlen, S.-M., & Kiesel, L. (2024) · Gynäkologische Endokrinologie · doi:10.1007/s10304-024-00569-y
Sex differences in cardiovascular, renal, and metabolic responses to androgens
Cardozo, L. L. Y., Rezq, S., Reckelhoff, J. F., & Romero, D. G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22266-5.00001-x
Wahood, W., Bucak, B., Oakley, C. I., & Keser, Z. (2025) · The Neurologist · doi:10.1097/nrl.0000000000000596
Risk of Cardiovascular Disease among Women with PCOS
Chopra, A., & Bhattacharya, S. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898810962125010013
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- Authors
- Zhou, Y., Wang, X., Jiang, Y., Ma, H., Chen, L., Lai, C., Peng, C., He, C., & Sun, C.
- Affiliations
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Corresponding author
- Sun, Chaofeng
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2017-07-11
- Volume
- 33
- Issue
- 12
- Pages
- 904-910
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2735461344
- Cited by
- 64
- References
- 38
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 3
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Neurology › Cerebral Venous Sinus Thrombosis
- Keywords
- polycystic ovary syndrome, stroke risk, all-cause mortality, body mass index, cardiovascular risk, risk stratification
- MeSH terms
- Female, Humans, Polycystic Ovary Syndrome, Body Mass Index, Stroke
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