The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Hypothyroidism prevalence in the United States: a retrospective study combining National Health and Nutrition Examination Survey and claims data, 2009-2019.
Open accessAbstract
Previous estimates determined prevalence of hypothyroidism (HT) to be 4.6% of the US population. This study aimed to update estimates of HT prevalence in the United States by retrospective analysis of 2 datasets. Data on HT type (overt or subclinical HT) and treatment were collected from the 2009-2010 and 2011-2012 National Health and Nutrition Examination Survey (NHANES) cycles. From the Optum administrative claims database, medical and pharmacy claims were collected between January 1, 2012, and December 31, 2019. Patients were defined as having HT if, per given year, they had >1 prescription for HT treatment, >1 claim indicating an HT diagnosis, or thyroid-stimulating hormone levels >4.0 mIU/L (NHANES arm). For both studies, treatment was defined as any evidence of synthetic or natural thyroid hormone replacement, identified by pharmacy claims or patient surveys. Data are reported as percentage of patients with HT and treatments received. Between 2009 and 2012, HT prevalence remained around 9.6% of the US population. The administrative claims dataset showed that HT prevalence grew from 9.5% in 2012 to 11.7% in 2019 and that >78% of patients received thyroxine (T4) monotherapy. Similarly, the NHANES dataset showed that T4 replacement therapy was the most common treatment for HT. From 2012-2019, patients with untreated HT grew from 11.8% to 14.4%. The prevalence of HT in the United States has steadily increased since 2009. Likewise, the percentage of hypothyroid-diagnosed patients not receiving treatment also increased, suggesting that the increased prevalence may be due to increased cases of subclinical HT.
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“Hypothyroidism is more frequent in Asian and White individuals compared with Black individuals, 21,22 whichmaybeduetoenvironmentalfactors(eg,areas with inadequate nutritional iodine levels), genetic factors, or both ( Box ). 22-25”
From Hypothyroidism: A Review (2025) · cites this paper as [21]
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“prevalence in the USA increased from 9.5% (2012) to 11.7% (2019), with over 78% receiving LT4 alone (9)”
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Cites
Home visits: a strategy to improve newborn survival - Authors' reply
(2008) · Americanae (AECID Library) · doi:10.1016/s0140 · Cited by 22,524
Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000950 · Cited by 5,784
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.489 · Cited by 4,279
The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey
Vanderpump, M. P. J., Tunbrldge, W. M. G., French, J. M., Appleton, D., Bates, D., Clark, F., Evans, J. G., Hasan, D. M., Rodgers, H., Tunbridge, F., et al. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01894.x · Cited by 2,432 · cited 1×
“A wait-and-see strategy is most common among patients with subclinical HT, as up to 4% of patients may go on to develop overt HT [2, 4, 5].”
BackgroundTransmission of SARS-COV-2 Infections in Households — Tennessee and Wisconsin, April–September 2020
Grijalva, C. G., Rolfes, M. A. R., Zhu, Y., McLean, H. Q., Hanson, K. E., Belongia, E. A., Halasa, N., Kim, A., Reed, C., Fry, A. M., et al. (2020) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6944e1 · Cited by 1,609
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567
Chaker, L., Bianco, A. C., Jonklaas, J., & Peeters, R. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30703-1 · Cited by 1,159
2013 ETA Guideline: Management of Subclinical Hypothyroidism
Pearce, S. H. S., Brabant, G., Duntas, L. H., Monzani, F., Peeters, R. P., Razvi, S., & Wemeau, J.-L. (2013) · European Thyroid Journal · doi:10.1159/000356507 · Cited by 877
Hypertension Prevalence Among Adults Aged 18 and Over: United States, 2017-2018.
Ostchega, Y., Fryar, C. D., Nwankwo, T., & Nguyễn, D. (2020) · PubMed · Cited by 497
Optimal recall periods for patient-reported outcomes: challenges and potential solutions
Stull, D. E., Leidy, N. K., Parasuraman, B. M., & Chassany, O. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990902774765 · Cited by 415 · cited 1×
“Likewise, data obtained from patient surveys rely on patient perspectives and memory and are, as a result, subject to recall bias, which could affect survey outcomes [31].”
Background
Research works printed but not linked: 2
- [3]Patil N, Rehman A, Jialal I. Hypothyroidism. Accessed August 4, 2021. https://www.ncbi.nlm.nih.gov/books/NBK519536/
- [9]National Institute for Healthcare and Excellence. Thyroid disease: assessment and management. NICE Guideline. 2019. 31829541
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Items 101–111 of 111
Ammar, A., & Al-Fartusie, F. S. D. (2026) · BioMetals · doi:10.1007/s10534-026-00838-2
“The prevalence rate of hypo-thyroidism in the United States is about 4.6% of the population, with about 15 new cases of hypothyroidism for every 1000 people every year (Wyne et al. 2022).”
InfluentialKoçak, S., Ünlü, G., Kalkan, K. T., Pektaş, F., & Türk, A. (2026) · Biology · doi:10.3390/biology15120932 · Cited by 1
Lindsey, W. W., Heiner, A. P., Barbieri, K. E., & Tomasulo, C. E. (2026) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2026-0036
“[6].”
Shekarian, A., Mazaheri‐Tehrani, S., Shekarian, S., Setudeh, M., Pourbazargan, M., Amani‐Beni, R., & Heidarpour, M. (2026) · BMC Endocrine Disorders · doi:10.1186/s12902-026-02376-x
“In contrast, iodine deficiency remains the predominant etiology in areas with insufficient dietary iodine [67].”
InfluentialCentral Sleep Apnea in Renal and Endocrine Disease
Murase, K., & Lyons, O. D. (2026) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2026.05.003
Alharby, T. N., Almuntashiri, S., Alshammari, M., Alshammari, S. H., Alzabni, A. F., Alnomassi, A. A., Alrashidi, H. S., Alghamdi, S., Ahemad, N., & Anwar, S. (2026) · Clinics and Practice · doi:10.3390/clinpract16070128
“…inverse association between age and hypothyroid odds in this cohort, where younger patients had higher odds of active disease, argues against age-based selective screening in this particular clinical setting and instead supports systematic biochemical assessment across all adult age groups [16,29].”
Conrad, D., Bianco, A. C., Bauer, A. J., Gregg, B., Josefson, J. L., SHAH, A. S., Trivedi, S., Huisingh, C., Mantis, S., Flores, O. A., et al. (2026) · Endocrine Practice · doi:10.1016/j.eprac.2026.08.003
Bovo, G., Mazzeo, P., Antonelli, G., Barbot, M., Ceccato, F., & Tizianel, I. (2026) · Journal of Endocrinological Investigation · doi:10.1007/s40618-026-03023-x
Delivery of liothyronine by microneedle patch for the treatment of hypothyroidism
Gomaa, Y. A., Hasin, T., Griffin, M. N., Nguyen, T. C., Noel, R. K., O’Farrell, L., McAninch, E. A., Kaiser, A. M., Wood, L. B., & Prausnitz, M. R. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-026-02214-6
Duan, Y., Wang, Y., Li, F., Li, W., Zhang, D., & Cui, Y. (2026) · Nutrients · doi:10.3390/nu18183085
“In the United States, diagnostic and epidemiologic trends of hypothyroidism have also increased significantly; among women, prevalence rose from 14.1% in 2012 to 17.0% in 2019, while among men it increased from 4.4% to 5.9% over the same period [3].”
InfluentialWell-controlled hypothyroidism does not affect the macronutrient composition of colostrum
Jassem-Bobowicz, J. M., Pastuszak, B., Sokołowska, E. M., Drążkowska, I., Narkowicz, S., & Domżalska-Popadiuk, I. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1921550
Metadata
- Authors
- Wyne, K. L., Nair, L., Schneiderman, C. P., Pinsky, B., Antunez Flores, O., Guo, D., Barger, B., & Tessnow, A. H.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- AbbVie (United States) (US)
- AbbVie, Inc. , Chicago, IL , USA
- Division of Endocrinology, Diabetes, and Metabolism, University of Texas Southwestern Medical Center , Dallas, TX , USA
- Venue
- Journal of the Endocrine Society
- Publisher
- The Endocrine Society
- Published
- 2022-11-10
- Volume
- 7
- Issue
- 1
- Pages
- bvac172-bvac172
- ISSN
- 2472-1972 (ISSN-L)
- PMC
- PMC9706417
- OpenAlex
- W4308881891
- Cited by
- 111
- References
- 28
- Citations by year
- 2026: 28 · 2025: 34 · 2024: 34 · 2023: 15
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of the Endocrine Society (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- AbbVie
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- hypothyroidism, prevalence, subclinical hypothyroidism, overt hypothyroidism, thyroid hormone replacement, levothyroxine monotherapy, untreated hypothyroidism, thyroid-stimulating hormone, United States
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