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Cited by 780

The DOI matches its OpenAlex record; 4 of the 4 references it cites were found in a registry or an index.

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

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Maribel Rios, Guoping Fan, Csaba Fekete, Joseph Kelly, Brian Bates, Ralf Kuehn, Ronald Michael Lechan, Rudolf Jaenisch·2001·Molecular Endocrinology
DOI 10.1210/me.15.10.1748
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Abstract

Brain-derived neurotrophic factor has been associated previously with the regulation of food intake. To help elucidate the role of this neurotrophin in weight regulation, we have generated conditional mutants in which brain-derived neurotrophic factor has been eliminated from the brain after birth through the use of the cre-loxP recombination system. Brain-derived neurotrophic factor conditional mutants were hyperactive after exposure to stressors and had higher levels of anxiety when evaluated in the light/dark exploration test. They also had mature onset obesity characterized by a dramatic 80-150% increase in body weight, increased linear growth, and elevated serum levels of leptin, insulin, glucose, and cholesterol. In addition, the mutants had an abnormal starvation response and elevated basal levels of POMC, an anorexigenic factor and the precursor for alpha-MSH. Our results demonstrate that brain derived neurotrophic factor has an essential maintenance function in the regulation of anxiety-related behavior and in food intake through central mediators in both the basal and fasted state.

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Research works printed but not linked: 41

  1. Jones, 1994, Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development., Cell, 76, 989, 10.1016/0092-8674(94)90377-8 · DOI · Paper page
  2. Kernie, 2000, BDNF regulates eating behavior and locomotor activity in mice., EMBO J, 19, 1290, 10.1093/emboj/19.6.1290 · DOI · Paper page
  3. Lyons, 1999, Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities., Proc Natl Acad Sci USA, 96, 15239, 10.1073/pnas.96.26.15239 · DOI · Paper page
  4. Kristensen, 1998, Hypothalamic CART is a new anorectic peptide regulated by leptin., Nature, 393, 72, 10.1038/29993 · DOI · Paper page
  5. Ollmann, 1997, Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein., Science, 278, 135, 10.1126/science.278.5335.135 · DOI · Paper page
  6. Pollock, 1981, Peripherally administered serotonin decreases food intake in rats., Pharmacol Biochem Behav, 15, 179, 10.1016/0091-3057(81)90174-X · DOI
  7. Shimada, 1998, Mice lacking melanin-concentrating hormone are hypophagic and lean., Nature, 396, 670, 10.1038/25341 · DOI · Paper page
  8. Stanley, 1985, Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior., Proc Natl Acad Sci USA, 82, 3940, 10.1073/pnas.82.11.3940 · DOI · Paper page
  9. Vijayan, 1977, Supression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH)., Endocrinology, 100, 1727, 10.1210/endo-100-6-1727 · DOI
  10. Yaswen, 1999, Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin., Nat Med, 5, 1066, 10.1038/12506 · DOI · Paper page
  11. Gu, 1994, Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting., Science, 265, 103, 10.1126/science.8016642 · DOI · Paper page
  12. Capecchi, 1989, Altering the genome by homologous recombination., Science, 244, 1288, 10.1126/science.2660260 · DOI · Paper page
  13. Minichiello, 1999, Essential role for TrkB receptors in hippocampus-mediated learning., Neuron, 24, 401, 10.1016/S0896-6273(00)80853-3 · DOI · Paper page
  14. Soriano, 1999, Generalized lacZ expression with the ROSA26 Cre reporter strain., Nat Genet, 21, 70, 10.1038/5007 · DOI · Paper page
  15. Fletcher, 1986, Hormonal studies of young lean and obese Zucker rats., Horm Metab Res, 18, 290, 10.1055/s-2007-1012299 · DOI
  16. Malewiak, 1977, Nutritionally induced variations in insulinaemia, blood ketone bodies and plasma and liver triglycerides in genetically obese rats., Diabete Metab, 3, 81
  17. Saladin, 1995, Transient increase in obese gene expression after food intake or insulin administration., Nature, 377, 527, 10.1038/377527a0 · DOI · Paper page
  18. Seino, 1984, Changes in insulin, somatostatin, and glucagon secretion during the development of obesity in ventromedial hypothalamic-lesioned rats., Endocrinology, 114, 457, 10.1210/endo-114-2-457 · DOI
  19. Trayhurn, 1995, Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (oblob) mice., FEBS Lett, 368, 488, 10.1016/0014-5793(95)00719-P · DOI · Paper page
  20. Schwartz, 2000, Central nervous system control of food intake., Nature, 404, 661, 10.1038/35007534 · DOI · Paper page
  21. Boden, 1981, Effects of starvation and obesity on somatostatin, insulin, and glucagon release from an isolated perfused organ system, Am J Physiol, 241, E215
  22. Triscari, 1980, Metabolic consequences of fasting in old lean and obese Zucker rats., Metabolism, 29, 377, 10.1016/0026-0495(80)90013-X · DOI
  23. Mizuno, 1999, Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin., Endocrinology, 140, 4551, 10.1210/endo.140.10.6966 · DOI
  24. Schwartz, 1997, Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus, Diabetes., 46, 2119, 10.2337/diab.46.12.2119 · DOI · Paper page
  25. Mountjoy, 1994, Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain., Mol Endocrinol, 8, 1298
  26. Mamounas, 1995, Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain., J Neurosci, 15, 7929, 10.1523/JNEUROSCI.15-12-07929.1995 · DOI · Paper page
  27. Siuciak, 1998, BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain., J Neurosci Res, 52, 149, 10.1002/(SICI)1097-4547(19980415)52:2<149::AID-JNR3>3.0.CO;2-A · DOI
  28. Tonra,, 1999, Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice., Diabetes, 48, 588, 10.2337/diabetes.48.3.588 · DOI
  29. Miknyoczki, 1999, Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior., Int J Cancer, 81, 417, 10.1002/(SICI)1097-0215(19990505)81:3<417::AID-IJC16>3.0.CO;2-6 · DOI
  30. Suter-Crazzolara, 1996, Expression of neurotrophins and their receptors in the developing and adult rat adrenal gland., Brain Res Mol Brain Res, 43, 351, 10.1016/S0169-328X(96)00243-4 · DOI
  31. Lauterio, 1999, Neuropeptide Y expression and endogenous leptin concentrations in a dietary model of obesity., Obes Res, 7, 498, 10.1002/j.1550-8528.1999.tb00439.x · DOI
  32. Tritos, 1998, Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice., Endocrinology, 139, 4634, 10.1210/endo.139.11.6308 · DOI · Paper page
  33. Pelleymounter, 1995, Characteristics of BDNF-induced weight loss., Exp Neurol, 131, 229, 10.1016/0014-4886(95)90045-4 · DOI · Paper page
  34. Huszar, 1997, Targeted disruption of the melanocortin-4 receptor results in obesity in mice., Cell, 88, 131, 10.1016/S0092-8674(00)81865-6 · DOI · Paper page
  35. Dubuc, 1976, The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice., Metabolism, 25, 1567, 10.1016/0026-0495(76)90109-8 · DOI
  36. Joosten, 1974, Growth pattern and behavioral traits associated with the development of the obese-hyperglycemic syndrome in mice (ob-ob)., Metabolism, 23, 1141, 10.1016/0026-0495(74)90030-4 · DOI
  37. Barnea, 1995, Brain-derived neurotrophic factor induces functional expression and phenotypic differentiation of cultured fetal neuropeptide Y-producing neurons., J Neurosci Res, 42, 638, 10.1002/jnr.490420506 · DOI
  38. Nawa, 1994, Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain., J Neurosci, 14, 3751, 10.1523/JNEUROSCI.14-06-03751.1994 · DOI
  39. Baumgartner, 1998, Rat brain type II 5′-iodothyronine deiodinase activity is extremely sensitive to stress., J Neurochem, 71, 817, 10.1046/j.1471-4159.1998.71020817.x · DOI
  40. Ragnauth, 2001, Female preproenkephalin-knockout mice display altered emotional responses., Proc Natl Acad Sci USA, 98, 1958, 10.1073/pnas.98.4.1958 · DOI
  41. van Gaalen, 2000, Behavioural analysis of four mouse strains in an anxiety test battery., Behav Brain Res, 115, 95, 10.1016/S0166-4328(00)00240-0 · DOI · Paper page

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Metadata

Authors
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., & Jaenisch, R.
Venue
Molecular Endocrinology
Publisher
The Endocrine Society
Published
2001-10-01
Volume
15
Issue
10
Pages
1748-1757
ISSN
  • 0888-8809 (ISSN-L)
  • 1944-9917
DOI
10.1210/me.15.10.1748
OpenAlex
W2038122755
Cited by
780
References
4
FWCI
6.23
Type
journal article
Language
en
Open access
bronze

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