The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nur77 Coordinately Regulates Expression of Genes Linked to Glucose Metabolism in Skeletal Muscle
Open accessAbstract
Innervation is important for normal metabolism in skeletal muscle, including insulin-sensitive glucose uptake. However, the transcription factors that transduce signals from the neuromuscular junction to the nucleus and affect changes in metabolic gene expression are not well defined. We demonstrate here that the orphan nuclear receptor Nur77 is a regulator of gene expression linked to glucose utilization in muscle. In vivo, Nur77 is preferentially expressed in glycolytic compared with oxidative muscle and is responsive to β-adrenergic stimulation. Denervation of rat muscle compromises expression of Nur77 in parallel with that of numerous genes linked to glucose metabolism, including glucose transporter 4 and genes involved in glycolysis, glycogenolysis, and the glycerophosphate shuttle. Ectopic expression of Nur77, either in rat muscle or in C2C12 muscle cells, induces expression of a highly overlapping set of genes, including glucose transporter 4, muscle phosphofructokinase, and glycogen phosphorylase. Furthermore, selective knockdown of Nur77 in rat muscle by small hairpin RNA or genetic deletion of Nur77 in mice reduces the expression of a battery of genes involved in skeletal muscle glucose utilization in vivo. Finally, we show that Nur77 binds the promoter regions of multiple genes involved in glucose metabolism in muscle. These results identify Nur77 as a potential mediator of neuromuscular signaling in the control of metabolic gene expression.
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Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine · doi:10.1038/78693 · Cited by 743
Michael, L. F., Wu, Z., Cheatham, R. B., Puigserver, P., Adelmant, G., Lehman, J. J., Kelly, D. P., & Spiegelman, B. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061035098 · Cited by 663
Kennedy, J. W., Hirshman, M. F., Gervino, E. V., Ocel, J. V., Forse, R. A., Hoenig, S. J., Aronson, D., Goodyear, L. J., & Horton, E. S. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1192 · Cited by 415
Contraction signaling to glucose transport in skeletal muscle
Jessen, N., & Goodyear, L. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00175.2005 · Cited by 311 · cited 1×
“Although the evidence pointing to a link between Nur77 and sympathetic innervation-induced metabolic changes in skeletal muscle is compelling, our data does not preclude the possibility that Nur77 may also regulate contraction (motor-neuron)-induced glucose transport (38) and glycogenolysis (36).”
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Cited by
Metabolic signatures of exercise in human plasma
Lewis, G. D., Farrell, L., Wood, M. J., Martinovic, M., Arany, Z., Rowe, G. C., Souza, A., Cheng, S., McCabe, E. L., Yang, E., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001006 · Cited by 432
Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
Dos Santos, M., Backer, S., Saintpierre, B., Izac, B., Andrieu, M., Letourneur, F., Relaix, F., Sotiropoulos, A., & Maire, P. (2020) · Nature Communications · doi:10.1038/s41467-020-18789-8 · Cited by 259
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Zhan, Y.-Y., Chen, Y., Zhang, Q., Zhuang, J.-J., Tian, M., Chen, H.-Z., Zhang, L.-R., Zhang, H.-K., He, J.-P., Wang, W.-J., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1069 · Cited by 180
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77
Chao, L. C., Wroblewski, K., Zhang, Z., Pei, L., Vergnes, L., Ilkayeva, O. R., Ding, S. Y., Reue, K., Watt, M. J., Newgard, C. B., et al. (2009) · Diabetes · doi:10.2337/db09-0763 · Cited by 154
“Our finding that Nur77 null mice have increased susceptibility for skeletal muscle insulin resistance is nevertheless consistent with the biologic pathways Nur77 regulates in muscle (17) and illustrates specifically the importance of muscle Nur77 in the regulation of whole-body glucose metabolism.”
InfluentialSelf-citationQiang, L., Lin, H. V., Kim-Muller, J. Y., Welch, C. L., Gu, W., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.007 · Cited by 122
Metadata
- Authors
- Chao, L. C., Zhang, Z., Pei, L., Saito, T., Tontonoz, P., & Pilch, P. F.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-09-01
- Volume
- 21
- Issue
- 9
- Pages
- 2152-2163
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2138936127
- Cited by
- 176
- References
- 4
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Chao, L. C., Zhang, Z., Pei, L., Saito, T., Tontonoz, P., & Pilch, P. F. (2007). Nur77 Coordinately Regulates Expression of Genes Linked to Glucose Metabolism in Skeletal Muscle. Molecular Endocrinology. https://doi.org/10.1210/me.2007-0169
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