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Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation
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Constitutive Sirt1 overexpression in Ldlr−/− mice was associated with increased atherosclerosis.
“Furthermore, constitutive Sirt1 overexpression in Ldlr−/− mice was associated with increased atherosclerosis.5”
From The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression (2015) · cites this paper as [5]
Genetic overexpression of Sirt1 in Ldlr−/− mice enhanced atherosclerosis.
“Sirt1 has been shown to be atheroprotective in apolipoprotein E-deficient (Apoe−/−) mice2–4 whereas genetic overexpression of Sirt1 in LDL-receptor-deficient (Ldlr−/−) mice enhanced atherosclerosis.5”
From The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression (2015) · cites this paper as [5]
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Cites
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Phosphorylated CREB binds specifically to the nuclear protein CBP
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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase
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Flagged first, then by citations
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Cited by
Sorted by citations
Effects of aging on angiogenesis
Lähteenvuo, J., & Rosenzweig, A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246116 · Cited by 292
Resveratrol as a calorie restriction mimetic: therapeutic implications
Chung, J. H., Manganiello, V., & Dyck, J. R. B. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.004 · Cited by 192
Miranda, M. X., van Tits, L. J., Lohmann, C., Arsiwala, T., Winnik, S., Tailleux, A., Stein, S., Gomes, A. P., Suri, V., Ellis, J. L., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu095 · Cited by 153
Metabolic effects of resveratrol: Addressing the controversies
Bitterman, J. L., & Chung, J. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1808-8 · Cited by 109
Ortega, I., Villanueva, J. A., Wong, D. H., Cress, A. B., Sokalska, A., Stanley, S. D., & Duleba, A. J. (2012) · Endocrinology · doi:10.1210/en.2012-1385 · Cited by 57
Unraveling the Complexities of SIRT1-Mediated Mitochondrial Regulation in Skeletal Muscle
Philp, A., & Schenk, S. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182956803 · Cited by 39
Metadata
- Authors
- Qiang, L., Lin, H. V., Kim-Muller, J. Y., Welch, C. L., Gu, W., & Accili, D.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 14
- Issue
- 6
- Pages
- 758-767
- ISSN
- 1550-4131
- PMC
- PMC3237922
- Cited by
- 122
- References
- 7
- Language
- en
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